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    Reps1 RALBP1 associated Eps domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292944, updated on 9-Dec-2024

    Summary

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    Symbol
    Reps1provided by RGD
    Full Name
    RALBP1 associated Eps domain containing 1provided by RGD
    Primary source
    RGD:1307131
    See related
    EnsemblRapid:ENSRNOG00000059224 AllianceGenome:RGD:1307131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be located in clathrin-coated pit; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 150.6), Spleen (RPKM 82.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Reps1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (14517589..14595404)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (12697742..12775562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (13262049..13298347)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hdc homolog, cell cycle regulator Neighboring gene ABRA C-terminal like Neighboring gene epithelial cell transforming 2 like Neighboring gene uncharacterized LOC102549233 Neighboring gene coiled-coil domain containing 28A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. Dergai O, et al. Biochem Biophys Res Commun, 2010 Nov 12. PMID 20946875
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ralBP1-associated Eps domain-containing protein 1
    Names
    RalBP1 associated Eps domain containing protein
    ralBP1-associated Eps domain-containing protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394899.2 → NP_001381828.1  ralBP1-associated Eps domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JZY3
      Conserved Domains (3) summary
      smart00027
      Location:278 → 369
      EH; Eps15 homology domain
      PRK07764
      Location:131 → 228
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    2. NM_001394900.2 → NP_001381829.1  ralBP1-associated Eps domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JZY3
      Related
      ENSRNOP00000071230.2, ENSRNOT00000090703.3
      Conserved Domains (3) summary
      smart00027
      Location:278 → 369
      EH; Eps15 homology domain
      PRK07764
      Location:131 → 228
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    3. NM_001415798.1 → NP_001402727.1  ralBP1-associated Eps domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JZY3
      Related
      ENSRNOP00000103583.1, ENSRNOT00000146715.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      14517589..14595404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105158.2 → XP_038961086.1  ralBP1-associated Eps domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    2. XM_039105167.2 → XP_038961095.1  ralBP1-associated Eps domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    3. XM_039105163.2 → XP_038961091.1  ralBP1-associated Eps domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    4. XM_039105171.2 → XP_038961099.1  ralBP1-associated Eps domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    5. XM_039105181.2 → XP_038961109.1  ralBP1-associated Eps domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    6. XM_039105185.2 → XP_038961113.1  ralBP1-associated Eps domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:310 → 401
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    7. XM_039105175.2 → XP_038961103.1  ralBP1-associated Eps domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (3) summary
      smart00027
      Location:289 → 380
      EH; Eps15 homology domain
      PRK07764
      Location:163 → 260
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    8. XM_063284299.1 → XP_063140369.1  ralBP1-associated Eps domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZY3

    9. XM_039105212.2 → XP_038961140.1  ralBP1-associated Eps domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JZY3
      Related
      ENSRNOP00000091930.2, ENSRNOT00000096610.2
      Conserved Domains (3) summary
      smart00027
      Location:278 → 369
      EH; Eps15 homology domain
      PRK07764
      Location:131 → 228
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl27812
      Location:6 → 85
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    10. XM_063284301.1 → XP_063140371.1  ralBP1-associated Eps domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZY3

    11. XM_063284305.1 → XP_063140375.1  ralBP1-associated Eps domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JZY3

    12. XM_063284303.1 → XP_063140373.1  ralBP1-associated Eps domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZY3

    13. XM_039105204.2 → XP_038961132.1  ralBP1-associated Eps domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Related
      ENSRNOP00000075677.3, ENSRNOT00000089607.3
      Conserved Domains (2) summary
      smart00027
      Location:258 → 349
      EH; Eps15 homology domain
      PRK07764
      Location:111 → 208
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    14. XM_039105200.2 → XP_038961128.1  ralBP1-associated Eps domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GJC5
      Conserved Domains (2) summary
      smart00027
      Location:264 → 355
      EH; Eps15 homology domain
      PRK07764
      Location:117 → 214
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    15. XM_063284307.1 → XP_063140377.1  ralBP1-associated Eps domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I6GJC5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106264.1: Suppressed sequence

      Description
      NM_001106264.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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