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    Lrrc28 leucine rich repeat containing 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361588, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Lrrc28provided by RGD
    Official Full Name
    leucine rich repeat containing 28provided by RGD
    Primary source
    RGD:1307209
    See related
    EnsemblRapid:ENSRNOG00000023274 AllianceGenome:RGD:1307209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in PML body. Orthologous to human LRRC28 (leucine rich repeat containing 28). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 57.9), Brain (RPKM 46.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc28 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130526757..130655991, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121116833..121245805, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128486164..128604190, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC103691157 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC108349234 Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene uncharacterized LOC120099844

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108486.1 → NP_001101956.1  leucine-rich repeat-containing protein 28

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A0A8I6ASL4, A6JBS5
      Related
      ENSRNOP00000030745.6, ENSRNOT00000033858.7
      Conserved Domains (2) summary
      sd00033
      Location:43 → 66
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:42 → 100
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      130526757..130655991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082302.2 → XP_038938230.1  leucine-rich repeat-containing protein 28 isoform X2

      Related
      ENSRNOP00000094953.2, ENSRNOT00000117149.2
      Conserved Domains (2) summary
      PRK15370
      Location:3 → 223
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:43 → 66
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_006229347.4 → XP_006229409.1  leucine-rich repeat-containing protein 28 isoform X3

      Conserved Domains (2) summary
      sd00033
      Location:43 → 66
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:42 → 100
      LRR_8; Leucine rich repeat

    3. XM_039082306.2 → XP_038938234.1  leucine-rich repeat-containing protein 28 isoform X5

      Conserved Domains (2) summary
      PRK15370
      Location:1 → 259
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:20 → 42
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_006229346.5 → XP_006229408.1  leucine-rich repeat-containing protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASL4, A6JBS5
      Conserved Domains (2) summary
      sd00033
      Location:43 → 66
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:42 → 100
      LRR_8; Leucine rich repeat

    5. XM_039082305.2 → XP_038938233.1  leucine-rich repeat-containing protein 28 isoform X4

      UniProtKB/TrEMBL
      A6JBS6, D4A4Y4
      Conserved Domains (2) summary
      PRK15370
      Location:22 → 213
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00031
      Location:24 → 46
      LRR_1; leucine-rich repeat [structural motif]

    6. XM_063266903.1 → XP_063122973.1  leucine-rich repeat-containing protein 28 isoform X6

      UniProtKB/TrEMBL
      A6JBS9

    7. XM_063266910.1 → XP_063122980.1  leucine-rich repeat-containing protein 28 isoform X6

      UniProtKB/TrEMBL
      A6JBS9
    Nucleotide Protein Strain
    Heading Accession and Version

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