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Conserved domains on  [gi|564328798|ref|XP_006229408|]
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leucine-rich repeat-containing protein 28 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 5.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  38 EGLQHLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLALPERLHLCLSLQYLTVDRNRLWCVPRHLCQLPSLNELSMAGNRLASLPv 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 564328798 198 DLGRSRELQYVYVDNNvNLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 5.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  38 EGLQHLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLALPERLHLCLSLQYLTVDRNRLWCVPRHLCQLPSLNELSMAGNRLASLPv 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 564328798 198 DLGRSRELQYVYVDNNvNLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-223 1.76e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798   3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-HLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370 181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLALPERLH 154
Cdd:PRK15370 251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564328798 155 lcLSLQYLTVDRNRLWCVPRHLCqlPSLNELSMAGNRLASLPVDLGRSreLQYVYVDNNVnLKGLPSYL 223
Cdd:PRK15370 325 --PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-196 6.38e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 6.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  38 EGLQHLERLYMKRNSLTTLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340   43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLALPERLHLClSLQYLTVDRNRLW---CVPRHLCQLPSLNELSMAGNRLA 193
Cdd:cd21340  104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEPLAPLR-NLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVC 181


                 ...
gi 564328798 194 SLP 196
Cdd:cd21340  182 KKP 184
LRR_8 pfam13855
Leucine rich repeat;
41-100 9.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564328798   41 QHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 5.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  38 EGLQHLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLALPERLHLCLSLQYLTVDRNRLWCVPRHLCQLPSLNELSMAGNRLASLPv 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 564328798 198 DLGRSRELQYVYVDNNvNLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-195 2.86e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 2.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQHLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTN 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  90 LQCLDLSdnaleivcpeigrlralrhlrlaNNQLQFLPPEVGDLKELQTLDISTNRLLALPErLHLCLSLQYLTVDRNRL 169
Cdd:COG4886  207 LEELDLS-----------------------GNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262

                        170       180
                 ....*....|....*....|....*.
gi 564328798 170 WCVPrHLCQLPSLNELSMAGNRLASL 195
Cdd:COG4886  263 TDLP-PLANLTNLKTLDLSNNQLTDL 287
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-223 1.76e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798   3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-HLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370 181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLALPERLH 154
Cdd:PRK15370 251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564328798 155 lcLSLQYLTVDRNRLWCVPRHLCqlPSLNELSMAGNRLASLPVDLGRSreLQYVYVDNNVnLKGLPSYL 223
Cdd:PRK15370 325 --PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-325 6.38e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.11  E-value: 6.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  45 RLYMKRNSLTTLPENLAQKLPNLVelyLHSNNIVVVPEAIGSLVKlqclDLSDNAleivcpeigrlralrhlrlanNQLQ 124
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLI---LDNNELKSLPENLQGNIK----TLYANS---------------------NQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 125 FLPPEVGDlkELQTLDISTNRLLALPErlHLCLSLQYLTVDRNRLWCVPRHLCQlpSLNELSMAGNRLASLPVDLGRSre 204
Cdd:PRK15370 234 SIPATLPD--TIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPSG-- 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 205 LQYVYVDNNvNLKGLPSYLynkvigcngcgiPIQLsevRLLTFSSGELTVF---LPAEVKAIGTEKDHVLPLQEltmrSL 281
Cdd:PRK15370 306 ITHLNVQSN-SLTALPETL------------PPGL---KTLEAGENALTSLpasLPPELQVLDVSKNQITVLPE----TL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564328798 282 HRTYHGLWKDLNFLspISLPKSL---LELLHCPLGHCHRCSEPMFTF 325
Cdd:PRK15370 366 PPTITTLDVSRNAL--TNLPENLpaaLQIMQASRNNLVRLPESLPHF 410
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
11-199 1.64e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.57  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  11 VARLEKHKNLFLNYRNLHHFPLELLKDEGLQHLERLYMKRNSLTTLPENLAQklpNLVELYLHSNNIVVVPEAIGslVKL 90
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPS---GITHLNVQSNSLTALPETLP--PGL 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  91 QCLDLSDNALEIVcPEIgrlralrhlrlannqlqfLPPEvgdlkeLQTLDISTNRLLALPERLHlcLSLQYLTVDRNRLW 170
Cdd:PRK15370 328 KTLEAGENALTSL-PAS------------------LPPE------LQVLDVSKNQITVLPETLP--PTITTLDVSRNALT 380

                        170       180       190
                 ....*....|....*....|....*....|
gi 564328798 171 CVPRHlcqLP-SLNELSMAGNRLASLPVDL 199
Cdd:PRK15370 381 NLPEN---LPaALQIMQASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-221 1.11e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  12 ARLEKHKNL---FLNYRNLH-HFPLELLKDEGLQHLERLYmkrNSLT-TLPENLAQkLPNLVELYLHSNNIV-VVPEAIG 85
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLSgEIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  86 SLVKLQCLDLSDNALEIVCPE--IGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLA-LPERLHLCLSLQYL 162
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPElvIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVL 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564328798 163 TVDRNRLWC-VPRHLCQLPSLNELSMAGNRLAS-LPVDLGRSRELQYVYVDNNvNLKG-LPS 221
Cdd:PLN00113 362 DLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDN-SFSGeLPS 422
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-213 3.89e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  39 GLQHLERLYMKRNSLT-TLPENLAQKLPNLVELYLhSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP-EIGRLRALRHL 116
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL-SNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 117 RLANNQLQ-FLPPEVGDLKELQTLDISTNRLLA-LPERLHLCLSLQYLTVDRNRLWC-VPRHLCQLPSLNELSMAGNRLA 193
Cdd:PLN00113 170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180
                 ....*....|....*....|.
gi 564328798 194 -SLPVDLGRSRELQYVYVDNN 213
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-225 4.38e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  74 SNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLALperl 153
Cdd:COG4886   36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN---- 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564328798 154 hlCLSLQYLTVDRNRLWCVPRHLCQLPSLNELSMAGNRLASLPVDLGRSRELQYVYVDNNvNLKGLPSYLYN 225
Cdd:COG4886  112 --LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELGN 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-223 8.17e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 8.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQHLERLYMKRNSLTTLPEnLAQkLPNLVELYLHSNNIVVVPEaIGSLVK 89
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLPE-LGN-LTNLEELDLSNNQLTDLPP-LANLTN 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLALPERLHLCLSLQYLTVDRNRL 169
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564328798 170 WCVPRHLCQLPSLNELSMAGNRLASLPVDLGRSRELQYVYVDNNVNLKGLPSYL 223
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-223 2.53e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.47  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  43 LERLYMKRNSLTTLPenlaQKLPNLVELYLHSNNIVVVPEAIGSLVKL-----------------QCLDLSDNALEIVcP 105
Cdd:PRK15387 244 LRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlppglQELSVSDNQLASL-P 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 106 EIgrLRALRHLRLANNQLQFLPPEVGDLKELQtldISTNRLLALPErlhLCLSLQYLTVDRNRLWCVPrhlcQLPS-LNE 184
Cdd:PRK15387 319 AL--PSELCKLWAYNNQLTSLPTLPSGLQELS---VSDNQLASLPT---LPSELYKLWAYNNRLTSLP----ALPSgLKE 386

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 564328798 185 LSMAGNRLASLPVdlgRSRELQYVYVDNN--VNLKGLPSYL 223
Cdd:PRK15387 387 LIVSGNRLTSLPV---LPSELKELMVSGNrlTSLPMLPSGL 424
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-196 6.38e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 6.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  38 EGLQHLERLYMKRNSLTTLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340   43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLALPERLHLClSLQYLTVDRNRLW---CVPRHLCQLPSLNELSMAGNRLA 193
Cdd:cd21340  104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEPLAPLR-NLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVC 181


                 ...
gi 564328798 194 SLP 196
Cdd:cd21340  182 KKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 20-218 4.55e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  20 LFLNYRNLHHFPLELLK------DEGLQHLERlYMKRNSLTTLPENLAQKLPNLVELYLHSNNIV-VVPEAIGSLVKLQC 92
Cdd:PLN00113  19 LFLNFSMLHAEELELLLsfkssiNDPLKYLSN-WNSSADVCLWQGITCNNSSRVVSIDLSGKNISgKISSAIFRLPYIQT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  93 LDLSDNALEIVCPE--IGRLRALRHLRLANNQLQFLPPEvGDLKELQTLDISTNRLLA-LPERLHLCLSLQYLTVDRNRL 169
Cdd:PLN00113  98 INLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGGNVL 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564328798 170 WC-VPRHLCQLPSLNELSMAGNRL-ASLPVDLGRSRELQYVYVDNNvNLKG 218
Cdd:PLN00113 177 VGkIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYN-NLSG 226
LRR_8 pfam13855
Leucine rich repeat;
41-100 9.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564328798   41 QHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
18-77 2.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798   18 KNLFLNYRNLHHFPLELLKdeGLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-263 5.14e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 123 LQFLPPEvgdlkeLQTLDISTNRLLALPERLHLCLSLQYLTVDRNRLWCVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 189 GNRLASLPvdlGRSRELQYVYVDNN--VNLKGLPSYLYNKVIGCNG-CGIPIQLSEVRLLTFSSGELTVF--LPAEVKAI 263
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNNqlTSLPTLPSGLQELSVSDNQlASLPTLPSELYKLWAYNNRLTSLpaLPSGLKEL 387
PLN03150 PLN03150
hypothetical protein; Provisional
 125-220 7.67e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 7.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 125 FLPPEVGDLKELQTLDISTNRLL-ALPERLHLCLSLQYLTVDRNRL-WCVPRHLCQLPSLNELSMAGNRLAS-LPVDLGr 201
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSGrVPAALG- 511

                         90       100
                 ....*....|....*....|.
gi 564328798 202 SRELQYVY--VDNNVNLKGLP 220
Cdd:PLN03150 512 GRLLHRASfnFTDNAGLCGIP 532
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-193 3.50e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  43 LERLYMKRNSLTTLPenlaqKLPN-LVELYLHSNNIVVVPEAIGSLvklQCLDLSDNALEIVcPEIgrLRALRHLRLANN 121
Cdd:PRK15387 304 LQELSVSDNQLASLP-----ALPSeLCKLWAYNNQLTSLPTLPSGL---QELSVSDNQLASL-PTL--PSELYKLWAYNN 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 122 QLQFLPPEVGDLKEL-----------------QTLDISTNRLLALPerlHLCLSLQYLTVDRNRLWCVPRHLCQLPSLNE 184
Cdd:PRK15387 373 RLTSLPALPSGLKELivsgnrltslpvlpselKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETT 449


                 ....*....
gi 564328798 185 LSMAGNRLA 193
Cdd:PRK15387 450 VNLEGNPLS 458
PLN03150 PLN03150
hypothetical protein; Provisional
 79-169 2.18e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  79 VVPEAIGSLVKLQCLDLSDNALEIVcpeigrlralrhlrlannqlqfLPPEVGDLKELQTLDISTNRLL-ALPERLHLCL 157
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGN----------------------IPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT 490

                         90
                 ....*....|..
gi 564328798 158 SLQYLTVDRNRL 169
Cdd:PLN03150 491 SLRILNLNGNSL 502
LRR_9 pfam14580
Leucine-rich repeat;
33-98 2.37e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 2.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564328798   33 ELLKDEGLQHLER---LYMKRNSLTTLPENLAQKLPNLVELYLHSNNI--VVVPEAIGSLVKLQCLDLSDN 98
Cdd:pfam14580  53 EIRKLDGFPLLRRlktLLLNNNRICRIGEGLGEALPNLTELILTNNNLqeLGDLDPLASLKKLTFLSLLRN 123
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-195 3.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  46 LYMKRNSLTTLpENLAQkLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEIVCPeIGRLRALRHLRLANNQLQF 125
Cdd:cd21340    7 LYLNDKNITKI-DNLSL-CKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564328798 126 LppE-VGDLKELQTLDISTNRlLALPERLH--------LCLSLQYLTVDRNRLwCVPRHLCQLPSLNELSMAGNRLASL 195
Cdd:cd21340   83 V--EgLENLTNLEELHIENQR-LPPGEKLTfdprslaaLSNSLRVLNISGNNI-DSLEPLAPLRNLEQLDASNNQISDL 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-221 3.67e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  43 LERLYMKRNSLT-TLPENLAQKlpNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCPEigrlralrhlrlan 120
Cdd:PLN00113 454 LQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPD-------------- 517

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 121 nqlqflppEVGDLKELQTLDISTNRLLALperlhlclslqyltvdrnrlwcVPRHLCQLPSLNELSMAGNRLA-SLPVDL 199
Cdd:PLN00113 518 --------ELSSCKKLVSLDLSHNQLSGQ----------------------IPASFSEMPVLSQLDLSQNQLSgEIPKNL 567

                        170       180
                 ....*....|....*....|..
gi 564328798 200 GRSRELQYVYVDNNVNLKGLPS 221
Cdd:PLN00113 568 GNVESLVQVNISHNHLHGSLPS 589
LRR_8 pfam13855
Leucine rich repeat;
65-146 6.97e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798   65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSdnaleivcpeigrlralrhlrlaNNQLQFLPPEV-GDLKELQTLDIS 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLS-----------------------NNLLTTLSPGAfSGLPSLRYLDLS 57


                  ....
gi 564328798  143 TNRL 146
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-205 8.90e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 8.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798  40 LQHLERLYMKRNSLT-TLPENLAQkLPNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNAL-----EIVC-------- 104
Cdd:PLN00113 307 LQNLEILHLFSNNFTgKIPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCssgnlfkl 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 105 ------------PEIGRLRALRHLRLANNQLQF-LPPEVGDLKELQTLDISTNRLLA-LPERLHLCLSLQYLTVDRNRLW 170
Cdd:PLN00113 386 ilfsnslegeipKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNKFF 465

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328798 171 ------------------------CVPRHLCQLPSLNELSMAGNRLAS-LPVDLGRSREL 205
Cdd:PLN00113 466 gglpdsfgskrlenldlsrnqfsgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKL 525
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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