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    Arf6 ARF GTPase 6 [ Mus musculus (house mouse) ]

    Gene ID: 11845, updated on 13-Jan-2025

    Summary

    Official Symbol
    Arf6provided by MGI
    Official Full Name
    ARF GTPase 6provided by MGI
    Primary source
    MGI:MGI:99435
    See related
    Ensembl:ENSMUSG00000044147 AllianceGenome:MGI:99435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including G protein activity; guanyl ribonucleotide binding activity; and thioesterase binding activity. Involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of protein localization. Acts upstream of or within several processes, including erythrocyte apoptotic process; hepatocyte apoptotic process; and liver development. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ARF GTPase 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 90.2), colon adult (RPKM 84.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Arf6 in Genome Data Viewer
    Location:
    12 C2; 12 28.81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69418924..69422754)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69372150..69375980)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene STARR-seq mESC enhancer starr_32366 Neighboring gene STARR-positive B cell enhancer ABC_E10755 Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70523938-70524137 Neighboring gene STARR-positive B cell enhancer ABC_E8486 Neighboring gene STARR-positive B cell enhancer ABC_E11513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70559664-70559829 Neighboring gene RIKEN cDNA 5830428M24 gene Neighboring gene predicted gene, 40434 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70576247-70576548

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102530

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity  
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity PubMed 
    enables protein binding PubMed 
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    enables thioesterase binding  
    enables thioesterase binding  
    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in cell division  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cortical actin cytoskeleton organization  
    involved_in cortical actin cytoskeleton organization  
    involved_in endocytic recycling  
    involved_in endocytic recycling  
    acts_upstream_of_or_within erythrocyte apoptotic process PubMed 
    acts_upstream_of_or_within establishment of epithelial cell polarity PubMed 
    acts_upstream_of_or_within hepatocyte apoptotic process PubMed 
    involved_in intracellular protein transport  
    acts_upstream_of_or_within liver development PubMed 
    involved_in maintenance of postsynaptic density structure  
    involved_in maintenance of postsynaptic density structure  
    involved_in negative regulation of dendrite development  
    involved_in negative regulation of dendrite development  
    involved_in negative regulation of protein localization to cell surface PubMed 
    involved_in nervous system development  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of focal adhesion disassembly PubMed 
    involved_in positive regulation of keratinocyte migration PubMed 
    involved_in positive regulation of mitotic cytokinetic process  
    involved_in positive regulation of mitotic cytokinetic process  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of protein secretion  
    involved_in protein localization to cell surface PubMed 
    involved_in protein localization to cleavage furrow  
    involved_in protein localization to cleavage furrow  
    involved_in protein localization to endosome  
    involved_in protein localization to endosome PubMed 
    involved_in protein localization to endosome  
    involved_in protein localization to endosome  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein transport PubMed 
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of dendritic spine development  
    involved_in regulation of dendritic spine development PubMed 
    involved_in regulation of dendritic spine development  
    involved_in regulation of filopodium assembly  
    involved_in regulation of filopodium assembly  
    acts_upstream_of_or_within regulation of neuron projection development PubMed 
    involved_in regulation of presynapse assembly  
    involved_in regulation of presynapse assembly  
    involved_in regulation of toll-like receptor 4 signaling pathway PubMed 
    involved_in ruffle assembly  
    involved_in ruffle assembly  
    involved_in synaptic vesicle endocytosis  
    involved_in synaptic vesicle endocytosis  
    involved_in vesicle-mediated transport  
    Items 1 - 25 of 56
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in Flemming body  
    located_in Golgi apparatus  
    located_in cell cortex  
    located_in cell cortex  
    is_active_in cleavage furrow  
    located_in cleavage furrow  
    located_in cleavage furrow  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in early endosome  
    located_in early endosome membrane  
    is_active_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome  
    located_in endosome PubMed 
    located_in filopodium membrane  
    located_in filopodium membrane  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in membrane  
    is_active_in midbody  
    located_in myelin sheath PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in postsynapse  
    located_in presynapse  
    is_active_in presynapse  
    located_in recycling endosome  
    is_active_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    is_active_in ruffle  
    located_in ruffle  
    located_in ruffle  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    ADP-ribosylation factor 6
    NP_031507.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007481.3NP_031507.1  ADP-ribosylation factor 6

      See identical proteins and their annotated locations for NP_031507.1

      Status: VALIDATED

      Source sequence(s)
      AC157822, AV587828, CJ167311
      Consensus CDS
      CCDS25952.1
      UniProtKB/Swiss-Prot
      P62331
      UniProtKB/TrEMBL
      Q3U0D7
      Related
      ENSMUSP00000055862.8, ENSMUST00000050063.9
      Conserved Domains (1) summary
      smart00177
      Location:1175
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69418924..69422754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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