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Acot4 acyl-CoA thioesterase 4 [ Mus musculus (house mouse) ]

Gene ID: 171282, updated on 27-Nov-2024

Summary

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Official Symbol
Acot4provided by MGI
Official Full Name
acyl-CoA thioesterase 4provided by MGI
Primary source
MGI:MGI:2159621
See related
Ensembl:ENSMUSG00000052392 AllianceGenome:MGI:2159621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pte1b; Pte2b; PTE-Ib; B430212I04Rik
Summary
Enables fatty acyl-CoA hydrolase activity. Involved in dicarboxylic acid metabolic process; short-chain fatty acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and respiratory system. Orthologous to human ACOT4 (acyl-CoA thioesterase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 13.6), kidney adult (RPKM 12.4) and 14 other tissues See more
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Genomic context

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See Acot4 in Genome Data Viewer
Location:
12 D1; 12 39.01 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84084028..84091497)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84037254..84044723)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene acyl-CoA thioesterase 2 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. Westin MA, et al. J Biol Chem, 2005 Nov 18. PMID 16141203
  2. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
  3. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. Hunt MC, et al. J Biol Chem, 1999 Nov 26. PMID 10567408
  4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
  5. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, et al. Cell, 2012 Dec 21. PMID 23260145

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 PubMed 
enables succinyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables succinyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dicarboxylic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dicarboxylic acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dicarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dicarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in saturated monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in saturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in short-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in unsaturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
peroxisomal succinyl-coenzyme A thioesterase
Names
PTE-2b
acyl-coenzyme A thioesterase 4
peroxisomal acyl coenzyme A thioester hydrolase Ib
peroxisomal acyl-CoA thioesterase 2B
peroxisomal long-chain acyl-CoA thioesterase Ib
NP_599008.3
XP_017170456.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134247.3 → NP_599008.3  peroxisomal succinyl-coenzyme A thioesterase

    See identical proteins and their annotated locations for NP_599008.3

    Status: VALIDATED

    Source sequence(s)
    AC133183, AK046630, BC113185
    Consensus CDS
    CCDS26035.1
    UniProtKB/Swiss-Prot
    Q8BJQ1, Q8BL20, Q8BWN8, Q9QYR8
    UniProtKB/TrEMBL
    Q14DI6
    Related
    ENSMUSP00000021652.4, ENSMUST00000021652.5
    Conserved Domains (3) summary
    pfam08840
    Location:204 → 412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:16 → 137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    cl21494
    Location:137 → 253
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84084028..84091497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314967.3 → XP_017170456.1  peroxisomal succinyl-coenzyme A thioesterase isoform X1

    Conserved Domains (1) summary
    pfam04775
    Location:16 → 137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

RNA

  1. XR_003949990.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWN8.1 GenPept UniProtKB/Swiss-Prot:Q8BWN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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