U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdk5rap2 CDK5 regulatory subunit associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286919, updated on 14-Nov-2024

    Summary

    Official Symbol
    Cdk5rap2provided by RGD
    Official Full Name
    CDK5 regulatory subunit associated protein 2provided by RGD
    Primary source
    RGD:708451
    See related
    EnsemblRapid:ENSRNOG00000005788 AllianceGenome:RGD:708451
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calmodulin binding activity; protein kinase binding activity; and tubulin binding activity. Involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and perinuclear region of cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in microtubule plus-end; mitotic spindle pole; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 140.4), Thymus (RPKM 81.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdk5rap2 in Genome Data Viewer
    Location:
    5q31
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (88807402..88976005, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (83792282..83961129, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (86387238..86554108, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102899 Neighboring gene uncharacterized LOC134478998 Neighboring gene uncharacterized LOC120102900 Neighboring gene small nucleolar RNA, H/ACA box 44 Neighboring gene multiple EGF-like-domains 9 Neighboring gene microRNA 3084c

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule organizing center organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of gamma-tubulin ring complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule plus-end IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in pericentriolar material IEA
    Inferred from Electronic Annotation
    more info
     
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentriolar material ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CDK5 regulatory subunit-associated protein 2
    Names
    CDK5 activator-binding protein C48

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173134.2NP_775157.2  CDK5 regulatory subunit-associated protein 2

      Status: PROVISIONAL

      Source sequence(s)
      CB806103, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      UniProtKB/TrEMBL
      F1M4B7
      Conserved Domains (4) summary
      COG0419
      Location:106615
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14731523
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14161553
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      88807402..88976005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109347.2XP_038965275.1  CDK5 regulatory subunit-associated protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A3G1T2C5
      Related
      ENSRNOP00000086004.2, ENSRNOT00000095599.2
      Conserved Domains (3) summary
      COG0419
      Location:105566
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:13391577
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
    2. XM_063287220.1XP_063143290.1  CDK5 regulatory subunit-associated protein 2 isoform X8

    3. XM_017593184.3XP_017448673.1  CDK5 regulatory subunit-associated protein 2 isoform X4

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
    4. XM_063287224.1XP_063143294.1  CDK5 regulatory subunit-associated protein 2 isoform X15

      Related
      ENSRNOP00000096134.2, ENSRNOT00000118617.2
    5. XM_006238277.5XP_006238339.1  CDK5 regulatory subunit-associated protein 2 isoform X6

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Related
      ENSRNOP00000073851.3, ENSRNOT00000083340.3
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14391489
      MreC; rod shape-determining protein MreC
      cl23765
      Location:13821519
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    6. XM_063287223.1XP_063143293.1  CDK5 regulatory subunit-associated protein 2 isoform X14

      Related
      ENSRNOP00000106827.1, ENSRNOT00000127377.1
    7. XM_006238276.5XP_006238338.1  CDK5 regulatory subunit-associated protein 2 isoform X5

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14411491
      MreC; rod shape-determining protein MreC
      cl23765
      Location:13841521
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    8. XM_006238279.5XP_006238341.1  CDK5 regulatory subunit-associated protein 2 isoform X11

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14711521
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14141551
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    9. XM_006238274.5XP_006238336.1  CDK5 regulatory subunit-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Related
      ENSRNOP00000086335.1, ENSRNOT00000095333.2
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14711521
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14141551
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    10. XM_006238280.5XP_006238342.1  CDK5 regulatory subunit-associated protein 2 isoform X13

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14731523
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14161553
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    11. XM_063287222.1XP_063143292.1  CDK5 regulatory subunit-associated protein 2 isoform X12

    12. XM_006238278.5XP_006238340.1  CDK5 regulatory subunit-associated protein 2 isoform X10

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14731523
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14161553
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    13. XM_008763760.4XP_008761982.1  CDK5 regulatory subunit-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6K7
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14731523
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14161553
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    14. XM_006238273.5XP_006238335.1  CDK5 regulatory subunit-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Related
      ENSRNOP00000007710.8, ENSRNOT00000007710.8
      Conserved Domains (4) summary
      pfam00769
      Location:147399
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:61129
      Cnn_1N; Centrosomin N-terminal motif 1
      cl19252
      Location:14731523
      MreC; rod shape-determining protein MreC
      cl23765
      Location:14161553
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    15. XM_039109346.2XP_038965274.1  CDK5 regulatory subunit-associated protein 2 isoform X7

      UniProtKB/Swiss-Prot
      K7QQW0, Q9JLH5
      Conserved Domains (2) summary
      COG1196
      Location:85402
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07989
      Location:1276
      Cnn_1N; Centrosomin N-terminal motif 1