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    TRIL TLR4 interactor with leucine rich repeats [ Homo sapiens (human) ]

    Gene ID: 9865, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRILprovided by HGNC
    Official Full Name
    TLR4 interactor with leucine rich repeatsprovided by HGNC
    Primary source
    HGNC:HGNC:22200
    See related
    Ensembl:ENSG00000255690 MIM:613356; AllianceGenome:HGNC:22200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]
    Orthologs
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    Genomic context

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    See TRIL in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28953358..28958330, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29090882..29095853, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28992974..28997946, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:28330425-28331392 and GRCh37_chr7:28331393-28332360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28332361-28333326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28350942-28351442 Neighboring gene peptidylprolyl isomerase A pseudogene 80 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:28398093-28398687 Neighboring gene cAMP responsive element binding protein 5 Neighboring gene Sharpr-MPRA regulatory region 5389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25797 Neighboring gene Sharpr-MPRA regulatory region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18046 Neighboring gene VISTA enhancer hs1604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:28651065-28652264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29061318-29062086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29062087-29062854 Neighboring gene CPVL antisense RNA 2 Neighboring gene carboxypeptidase vitellogenic like Neighboring gene CPVL antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway. Liao J, et al. Cancer Biol Ther, 2022 Dec 31. PMID 35253622, Free PMC Article
    2. Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL). Carpenter S, et al. J Biol Chem, 2011 Nov 4. PMID 21911501, Free PMC Article
    3. Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l. Kim HS, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34475212, Free PMC Article
    4. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. Carpenter S, et al. J Immunol, 2009 Sep 15. PMID 19710467
    5. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Büssow K, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776767, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
      Title: Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
    2. Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL)
      Title: Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0644

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TLR4 interactor with leucine rich repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014817.4 → NP_055632.2  TLR4 interactor with leucine rich repeats precursor

      See identical proteins and their annotated locations for NP_055632.2

      Status: VALIDATED

      Source sequence(s)
      AC005013, BC036337
      Consensus CDS
      CCDS75573.1
      UniProtKB/Swiss-Prot
      A4D1A6, O75139, Q7L0X0
      Related
      ENSP00000479256.1, ENST00000539664.3
      Conserved Domains (5) summary
      cd00116
      Location:249 → 364
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:351 → 363
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:85 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:589 → 667
      fn3; Fibronectin type III domain
      pfam13855
      Location:84 → 143
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      28953358..28958330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      29090882..29095853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L0X0.2 GenPept UniProtKB/Swiss-Prot:Q7L0X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials