NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|76880480|ref|NP_055632|]
View 

TLR4 interactor with leucine rich repeats precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-344 3.68e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 3.68e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNqirslhpKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANG 140
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 141 NEISRLSRgSFEGLESLVKLRLDGNALGALPDAvFAPLGNLLYLHLESNRIRFLGKnAFAQLGKLRFLNLSANELQpSLr 220
Cdd:COG4886 146 NQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-DL- 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 221 haatfaplrslsslilsannlqhlgPRIFQHLPRLGLLSLRGNQLTHLapEAFWGLEALRELRLEGNRLSQLPTalLEPL 300
Cdd:COG4886 221 -------------------------PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANL 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 76880480 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
PHA03378 super family cl33729
EBNA-3B; Provisional
 478-579 1.07e-04

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  478 NRSALRLSRRGPGLQQPSPSVAAAAGPaPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGT 557
Cdd:PHA03378 680 GANTMLPIQWAPGTMQPPPRAPTPMRP-PAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                         90       100
                 ....*....|....*....|..
gi 76880480  558 EHQERAAQSDGGAGLPPLVSDP 579
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTPQPPP 780
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 589-667 2.18e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   589 NLTVEAVGADSASVRWavrehRSPRPLGGA--RFRLLF-DRFGQQPKFHRFVylPESSDSATLRELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 76880480   666 GG 667
Cdd:pfam00041  78 GG 79
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-401 8.88e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 8.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480    332 LRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVfVQCRHPPALRGKYL 401
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-344 3.68e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 3.68e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNqirslhpKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANG 140
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 141 NEISRLSRgSFEGLESLVKLRLDGNALGALPDAvFAPLGNLLYLHLESNRIRFLGKnAFAQLGKLRFLNLSANELQpSLr 220
Cdd:COG4886 146 NQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-DL- 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 221 haatfaplrslsslilsannlqhlgPRIFQHLPRLGLLSLRGNQLTHLapEAFWGLEALRELRLEGNRLSQLPTalLEPL 300
Cdd:COG4886 221 -------------------------PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANL 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 76880480 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-317 3.80e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.76  E-value: 3.80e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  65 SLGGNFITNITafDFHRLGQLRRLDLQYNQIRSLhpKTFEKLSRLEELYLGNNLLQALAPgtLAPLRKLRILYANGNEIS 144
Cdd:cd21340   8 YLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 145 RLsrgsfEGLESLVKLRldgnalgalpdavfaplgnllYLHLESNRIrflgknafaQLG-KLRFLNLSANELQPSLRHaa 223
Cdd:cd21340  82 VV-----EGLENLTNLE---------------------ELHIENQRL---------PPGeKLTFDPRSLAALSNSLRV-- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 224 tfaplrslsslilsannlqhlgprifqhlprlglLSLRGNQLTHLAPeaFWGLEALRELRLEGNRLSQLP--TALLEPLH 301
Cdd:cd21340 125 ----------------------------------LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                       250
                ....*....|....*.
gi 76880480 302 SLEALDLSGNELSALH 317
Cdd:cd21340 169 SLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-362 5.78e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 5.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   66 LGGNF--------ITNITAFDF-------------HRLGQLRRLD---LQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA 121
Cdd:PLN00113 171 LGGNVlvgkipnsLTNLTSLEFltlasnqlvgqipRELGQMKSLKwiyLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  122 LAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL-GALPDAVfAPLGNLLYLHLESNriRFLGK---- 196
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELV-IQLQNLEILHLFSN--NFTGKipva 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  197 --------------NAF-----AQLGK---LRFLNLSAN----------------------------ELQPSLRHAATFa 226
Cdd:PLN00113 328 ltslprlqvlqlwsNKFsgeipKNLGKhnnLTVLDLSTNnltgeipeglcssgnlfklilfsnslegEIPKSLGACRSL- 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  227 plrslSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS-QLPTALLEplHSLEA 305
Cdd:PLN00113 407 -----RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGS--KRLEN 479

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 76880480  306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRR_8 pfam13855
Leucine rich repeat;
84-143 5.75e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.75e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480    84 QLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PHA03378 PHA03378
EBNA-3B; Provisional
 478-579 1.07e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  478 NRSALRLSRRGPGLQQPSPSVAAAAGPaPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGT 557
Cdd:PHA03378 680 GANTMLPIQWAPGTMQPPPRAPTPMRP-PAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                         90       100
                 ....*....|....*....|..
gi 76880480  558 EHQERAAQSDGGAGLPPLVSDP 579
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTPQPPP 780
fn3 pfam00041
Fibronectin type III domain;
589-667 2.18e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   589 NLTVEAVGADSASVRWavrehRSPRPLGGA--RFRLLF-DRFGQQPKFHRFVylPESSDSATLRELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 76880480   666 GG 667
Cdd:pfam00041  78 GG 79
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-401 8.88e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 8.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480    332 LRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVfVQCRHPPALRGKYL 401
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL 70
LRR smart00370
Leucine-rich repeats, outliers;
82-104 6.93e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.93e-03
                           10        20
                   ....*....|....*....|...
gi 76880480     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-344 3.68e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 3.68e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNqirslhpKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANG 140
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 141 NEISRLSRgSFEGLESLVKLRLDGNALGALPDAvFAPLGNLLYLHLESNRIRFLGKnAFAQLGKLRFLNLSANELQpSLr 220
Cdd:COG4886 146 NQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-DL- 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 221 haatfaplrslsslilsannlqhlgPRIFQHLPRLGLLSLRGNQLTHLapEAFWGLEALRELRLEGNRLSQLPTalLEPL 300
Cdd:COG4886 221 -------------------------PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANL 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 76880480 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-356 3.28e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 3.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  78 DFHRLGQLRRLDLQYNQIRSLhPKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANGNEISRLSRgSFEGLESL 157
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 158 VKLRLDGNALGALPDAvFAPLGNLLYLHLESNRIRFLGKnAFAQLGKLRFLNLSANELQ--PSLrhaatfaplrslssli 235
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTdlPEL---------------- 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 236 lsannlqhlgprifQHLPRLGLLSLRGNQLTHLAPEAfwGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSA 315
Cdd:COG4886 247 --------------GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 76880480 316 LhpATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDL 356
Cdd:COG4886 311 L--ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-359 8.24e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.12  E-value: 8.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 104 EKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEisrlsrgSFEGLESLVKLRLDGNALGALPDAvFAPLGNLLY 183
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 184 LHLESNRIRFLGKnAFAQLGKLRFLNLSANELQpSLrhaatfaplrslsslilsannlqhlgPRIFQHLPRLGLLSLRGN 263
Cdd:COG4886 141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT-DL--------------------------PEELGNLTNLKELDLSNN 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 264 QLTHLaPEAFWGLEALRELRLEGNRLSQLPTAlLEPLHSLEALDLSGNELSALhpATFGHLGRLRELSLRNNALSALSGd 343
Cdd:COG4886 193 QITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP- 267

                       250
                ....*....|....*.
gi 76880480 344 iFAASPALYRLDLDGN 359
Cdd:COG4886 268 -LANLTNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-359 2.26e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 2.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL 167
Cdd:COG4886   5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 168 GALPDAVFAPLGNLLYLHLESNrirflgkNAFAQLGKLRFLNLsanelqpslrhaatfaplrslsslilSANNLQHLGPR 247
Cdd:COG4886  85 LLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDL--------------------------SGNQLTDLPEE 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 248 IFQhLPRLGLLSLRGNQLTHLaPEAFWGLEALRELRLEGNRLSQLPTAlLEPLHSLEALDLSGNELSALhPATFGHLGRL 327
Cdd:COG4886 132 LAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNL 207

                       250       260       270
                ....*....|....*....|....*....|..
gi 76880480 328 RELSLRNNALSALSGDIfAASPALYRLDLDGN 359
Cdd:COG4886 208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-316 2.99e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  37 QHLLCTNRGLRVVPKT-SSLPSphdvLTY-SLGGNFITNITAFdFHRLGQLRRLDLQYNQIRSLhPKTFEKLSRLEELYL 114
Cdd:COG4886 139 KELDLSNNQLTDLPEPlGNLTN----LKSlDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 115 GNNLLQALaPGTLAPLRKLRILYANGNEISRLSrgSFEGLESLVKLRLDGNALGALPDAvfAPLGNLLYLHLESNRIRFL 194
Cdd:COG4886 213 SGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDL 287

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 195 GKNAFAQLGKLRFL--NLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEA 272
Cdd:COG4886 288 KLKELELLLGLNSLllLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 76880480 273 FWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSAL 316
Cdd:COG4886 368 TLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-317 3.80e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.76  E-value: 3.80e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  65 SLGGNFITNITafDFHRLGQLRRLDLQYNQIRSLhpKTFEKLSRLEELYLGNNLLQALAPgtLAPLRKLRILYANGNEIS 144
Cdd:cd21340   8 YLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 145 RLsrgsfEGLESLVKLRldgnalgalpdavfaplgnllYLHLESNRIrflgknafaQLG-KLRFLNLSANELQPSLRHaa 223
Cdd:cd21340  82 VV-----EGLENLTNLE---------------------ELHIENQRL---------PPGeKLTFDPRSLAALSNSLRV-- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 224 tfaplrslsslilsannlqhlgprifqhlprlglLSLRGNQLTHLAPeaFWGLEALRELRLEGNRLSQLP--TALLEPLH 301
Cdd:cd21340 125 ----------------------------------LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                       250
                ....*....|....*.
gi 76880480 302 SLEALDLSGNELSALH 317
Cdd:cd21340 169 SLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-362 5.78e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 5.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   66 LGGNF--------ITNITAFDF-------------HRLGQLRRLD---LQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA 121
Cdd:PLN00113 171 LGGNVlvgkipnsLTNLTSLEFltlasnqlvgqipRELGQMKSLKwiyLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  122 LAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL-GALPDAVfAPLGNLLYLHLESNriRFLGK---- 196
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELV-IQLQNLEILHLFSN--NFTGKipva 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  197 --------------NAF-----AQLGK---LRFLNLSAN----------------------------ELQPSLRHAATFa 226
Cdd:PLN00113 328 ltslprlqvlqlwsNKFsgeipKNLGKhnnLTVLDLSTNnltgeipeglcssgnlfklilfsnslegEIPKSLGACRSL- 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  227 plrslSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS-QLPTALLEplHSLEA 305
Cdd:PLN00113 407 -----RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGS--KRLEN 479

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 76880480  306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-359 3.83e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 3.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   63 TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNE 142
Cdd:PLN00113 144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  143 ISRLSRGSFEGLESLVKLRLDGNAL-GALPDAvFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ---PS 218
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLtGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeiPE 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  219 LrhaatFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS-QLPTALL 297
Cdd:PLN00113 303 L-----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLC 377

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 76880480  298 EPLHsLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Cdd:PLN00113 378 SSGN-LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438
LRR_8 pfam13855
Leucine rich repeat;
84-143 5.75e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.75e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480    84 QLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
239-289 2.67e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 2.67e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 76880480   239 NNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Cdd:pfam13855  11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
156-215 5.77e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 5.77e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   156 SLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL 215
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
107-167 1.64e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.64e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 76880480   107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
279-337 6.21e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 6.21e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 76880480   279 LRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNAL 337
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-337 1.27e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLR 161
Cdd:PLN00113 283 LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLD 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  162 LDGNAL-GALPDAVFAPlGNLLYLHLESN-----------------RIRfLGKNA--------FAQLGKLRFLNLSANEL 215
Cdd:PLN00113 363 LSTNNLtGEIPEGLCSS-GNLFKLILFSNslegeipkslgacrslrRVR-LQDNSfsgelpseFTKLPLVYFLDISNNNL 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  216 QPSLRHAATFAPLRSLSSLIL-----------SANNLQHLG----------PRIFQHLPRLGLLSLRGNQLTHLAPEAFW 274
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARnkffgglpdsfGSKRLENLDlsrnqfsgavPRKLGSLSELMQLKLSENKLSGEIPDELS 520

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 76880480  275 GLEALRELRLEGNRLS-QLPTALLEpLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNAL 337
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSgQIPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
302-359 3.90e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 3.90e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 76880480   302 SLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
65-119 1.07e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 76880480    65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 67-338 1.39e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   67 GGNFITNITAFDFHrLGQLRRLDLQYNQIRSLHPKT-FEKLSRLEELYLGNNLLQALAPGTLAPLrkLRILYANGNEIS- 144
Cdd:PLN00113  78 GKNISGKISSAIFR-LPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSg 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  145 --RLSRGSFEgleSLVKLRLDGNAL-GALPDAVfAPLGNLLYLHLESNRirFLGKNAfAQLGKLRFL--------NLSA- 212
Cdd:PLN00113 155 eiPNDIGSFS---SLKVLDLGGNVLvGKIPNSL-TNLTSLEFLTLASNQ--LVGQIP-RELGQMKSLkwiylgynNLSGe 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  213 --NELQ--PSLRHaatfaplrslssLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNR 288
Cdd:PLN00113 228 ipYEIGglTSLNH------------LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS 295

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 76880480  289 LSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338
Cdd:PLN00113 296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 249-364 4.07e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.74  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 249 FQHLPRLGLLSLRGNQLTHLAPEAFWGL---EALRELRLEGNRLSQLPT-----ALLEPLHSLEALDLSGNELSA--LHP 318
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGasCEA 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 76880480 319 A--TFGHLGRLRELSLRNNALS----ALSGDIFAASPALYRLDLDGNGWTCD 364
Cdd:cd00116 157 LakALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDE 208
LRR_8 pfam13855
Leucine rich repeat;
180-265 1.23e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANelqpslrhaatfaplrslsslilsanNLQHLGPRIFQHLPRLGLLS 259
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN--------------------------LLTTLSPGAFSGLPSLRYLD 55


                  ....*.
gi 76880480   260 LRGNQL 265
Cdd:pfam13855  56 LSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-359 1.88e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  87 RLDLQYNQIRSLHPKT-FEKLSRLEELYLGNNLLQALA----PGTLAPLRKLRILYANGNEISRLSRG---SFEGLESLV 158
Cdd:cd00116   2 QLSLKGELLKTERATElLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGlqsLLQGLTKGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 159 KLR---LDGNALGALPDAVFAPL---GNLLYLHLESNRirfLGKnafaqlGKLRFLNLSANELQPSLRhaatfaplrsls 232
Cdd:cd00116  82 GLQeldLSDNALGPDGCGVLESLlrsSSLQELKLNNNG---LGD------RGLRLLAKGLKDLPPALE------------ 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 233 SLILSANNLQHLGPR----IFQHLPRLGLLSLRGNQL-----THLApEAFWGLEALRELRLEGNRL----SQLPTALLEP 299
Cdd:cd00116 141 KLVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagiRALA-EGLKANCNLEVLDLNNNGLtdegASALAETLAS 219

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 76880480 300 LHSLEALDLSGNEL-----SALHPATFGHLGRLRELSLRNNALSALSGDIFA----ASPALYRLDLDGN 359
Cdd:cd00116 220 LKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGN 288
PLN03150 PLN03150
hypothetical protein; Provisional
 258-338 4.32e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  258 LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNAL 337
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 76880480  338 S 338
Cdd:PLN03150 503 S 503
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-194 5.78e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 5.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   2 EAARALRLLlvvcgCLALPPLAEPVCpercdcqhpqHLLCTNRGLRVVPKT---SSLPSPHDVLTYSLGGNfitNITAFD 78
Cdd:cd00116 120 LGDRGLRLL-----AKGLKDLPPALE----------KLVLGRNRLEGASCEalaKALRANRDLKELNLANN---GIGDAG 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  79 FHRLGQ-------LRRLDLQYNQIRSLHPK----TFEKLSRLEELYLGNNLL-----QALAPGTLAPLRKLRILYANGNE 142
Cdd:cd00116 182 IRALAEglkancnLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCND 261

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 76880480 143 ISRLSRGSF-EGL---ESLVKLRLDGNALGALPDAVFAPLgnllyLHLESNRIRFL 194
Cdd:cd00116 262 ITDDGAKDLaEVLaekESLLELDLRGNKFGEEGAQLLAES-----LLEPGNELESL 312
PHA03378 PHA03378
EBNA-3B; Provisional
 478-579 1.07e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  478 NRSALRLSRRGPGLQQPSPSVAAAAGPaPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGT 557
Cdd:PHA03378 680 GANTMLPIQWAPGTMQPPPRAPTPMRP-PAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                         90       100
                 ....*....|....*....|..
gi 76880480  558 EHQERAAQSDGGAGLPPLVSDP 579
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTPQPPP 780
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 84-124 1.53e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 76880480    84 QLRRLDLQYNQIRSLHPktFEKLSRLEELYL-GNNLLQALAP 124
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLsGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-320 1.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   83 GQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAplrKLRILY----ANGNEISRLSRGSFEgLESLV 158
Cdd:PLN00113 380 GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFT---KLPLVYfldiSNNNLQGRINSRKWD-MPSLQ 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  159 KLRLDGNA-LGALPDAVFAPlgNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLrhaatfaplrslsslils 237
Cdd:PLN00113 456 MLSLARNKfFGGLPDSFGSK--RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI------------------ 515

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  238 annlqhlgPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
Cdd:PLN00113 516 --------PDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSL 587


                 ...
gi 76880480  318 PAT 320
Cdd:PLN00113 588 PST 590
fn3 pfam00041
Fibronectin type III domain;
589-667 2.18e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   589 NLTVEAVGADSASVRWavrehRSPRPLGGA--RFRLLF-DRFGQQPKFHRFVylPESSDSATLRELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 76880480   666 GG 667
Cdd:pfam00041  78 GG 79
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 78-181 4.13e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   78 DFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549

                         90       100
                 ....*....|....*....|....*
gi 76880480  158 VKLRLDGNAL-GALPdavfAPLGNL 181
Cdd:PLN00113 550 SQLDLSQNQLsGEIP----KNLGNV 570
PHA03378 PHA03378
EBNA-3B; Provisional
 415-546 5.00e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  415 ADPSPSASLT------ADRRRQPlPTAAGEEMTPPAGlaEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRG 488
Cdd:PHA03378 674 YQPSPTGANTmlpiqwAPGTMQP-PPRAPTPMRPPAA--PPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAA 750

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 76880480  489 PGLQQPsPSVAAAAGPAPQSldlhkkpQRGRPTRADPALAEPTPTASPGSAPSPAGDP 546
Cdd:PHA03378 751 PGRARP-PAAAPGRARPPAA-------APGAPTPQPPPQAPPAPQQRPRGAPTPQPPP 800
PLN03150 PLN03150
hypothetical protein; Provisional
 78-144 5.04e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 76880480   78 DFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIS 144
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-401 8.88e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 8.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480    332 LRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVfVQCRHPPALRGKYL 401
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL 70
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
410-622 1.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  410 QNGSCADPSPSASLTAdrrrQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGP 489
Cdd:PRK12323 368 SGGGAGPATAAAAPVA----QPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  490 GLQQPSPSVAAAAGPAPQSldlhkKPQRGRPTRADPALAEPTPTASPGSAPSPAGD---PWQR--ATKHRLGTEHQERA- 563
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAA-----RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdppPWEElpPEFASPAPAQPDAAp 518

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 76880480  564 AQSDGGAGLPPLVSDPCDFNKfilcNLTVEAVGADSASVRWAVREHRSPRPLGGARFRL 622
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFE----TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGL 573
LRR_9 pfam14580
Leucine-rich repeat;
249-307 1.32e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 1.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 76880480   249 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTalLEPLHSLEALD 307
Cdd:pfam14580  60 FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGD--LDPLASLKKLT 116
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 237-337 2.40e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  237 SANNLQ-HLGPRIFqHLPRLGLLSLRGNQLTHLAPEA-FWGLEALRELRLEGNRLS-QLPTALLEplhSLEALDLSGNEL 313
Cdd:PLN00113  77 SGKNISgKISSAIF-RLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTgSIPRGSIP---NLETLDLSNNML 152

                         90       100
                 ....*....|....*....|....
gi 76880480  314 SALHPATFGHLGRLRELSLRNNAL 337
Cdd:PLN00113 153 SGEIPNDIGSFSSLKVLDLGGNVL 176
PLN03150 PLN03150
hypothetical protein; Provisional
 43-139 4.59e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   43 NRGLR-VVPktSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA 121
Cdd:PLN03150 427 NQGLRgFIP--NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504

                         90       100
                 ....*....|....*....|
gi 76880480  122 LAPGTLA--PLRKLRILYAN 139
Cdd:PLN03150 505 RVPAALGgrLLHRASFNFTD 524
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-315 5.04e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 103 FEKLSRLEELYLGNNLLQALAPGTLAPLRK---LRILYANGNEISR-----LSRGSFEGLESLVKLRLDGNALGALPDA- 173
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCEa 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480 174 ---VFAPLGNLLYLHLESNRIRFLG----KNAFAQLGKLRFLNLSANELQPSlrhaatfaplrslsslilsanNLQHLGp 246
Cdd:cd00116 157 lakALRANRDLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDE---------------------GASALA- 214

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 76880480 247 RIFQHLPRLGLLSLRGNQLT-----HLAPEAFWGLEALRELRLEGNRLSQLPT-ALLEPL---HSLEALDLSGNELSA 315
Cdd:cd00116 215 ETLASLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAkDLAEVLaekESLLELDLRGNKFGE 292
PLN03150 PLN03150
hypothetical protein; Provisional
 88-174 5.13e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480   88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL 167
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 76880480  168 -GALPDAV 174
Cdd:PLN03150 503 sGRVPAAL 510
LRR smart00370
Leucine-rich repeats, outliers;
82-104 6.93e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.93e-03
                           10        20
                   ....*....|....*....|...
gi 76880480     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
82-104 6.93e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.93e-03
                           10        20
                   ....*....|....*....|...
gi 76880480     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
415-574 7.65e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  415 ADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELvgNRSALRLSRRGPGLQQP 494
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR--EDAPAAAAPPAPEARPP 535

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880480  495 SPSVAAA---AGPAPQSLD------LHKKPQRGRPTRADPALAEPTPTASPGSAPSPA---GDPWQRATKHRLGTEHQER 562
Cdd:PRK07003 536 TPAAAAPaarAGGAAAALDvlrnagMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAvqvPTPRARAATGDAPPNGAAR 615

                        170
                 ....*....|..
gi 76880480  563 AAQSDGGAGLPP 574
Cdd:PRK07003 616 AEQAAESRGAPP 627
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 279-311 9.65e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 9.65e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 76880480   279 LRELRLEGNRLSQLPtaLLEPLHSLEALDLSGN 311
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH