Oxt oxytocin/neurophysin I prepropeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oxtprovided by RGD
Official Full Name: oxytocin/neurophysin I prepropeptideprovided by RGD
Primary source: RGD:3238
See related: EnsemblRapid:ENSRNOG00000021225 AllianceGenome:RGD:3238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables neuropeptide hormone activity and oxytocin receptor binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of smooth muscle contraction; and regulation of blood pressure. Located in extracellular space; secretory granule; and terminal bouton. Is active in neuronal dense core vesicle. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 36.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138235754..138236594)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117782650..117783490)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123106694..123107534)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats.
Title: Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats.
Neurobiological mechanisms underlying oxytocin-mediated parental behavior in rodents.
Title: Neurobiological mechanisms underlying oxytocin-mediated parental behavior in rodents.
Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes.
Title: Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes.
Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin.
Title: Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin.
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow.
Title: An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow.
Oestrogen-dependent hypothalamic oxytocin expression with changes in feeding and body weight in female rats.
Title: Oestrogen-dependent hypothalamic oxytocin expression with changes in feeding and body weight in female rats.
Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats.
Title: Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats.
Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions.
Title: Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions.
The action of oxytocin on the bone of senescent female rats.
Title: The action of oxytocin on the bone of senescent female rats.
Transgenic approaches to opening up new fields of vasopressin and oxytocin research.
Title: Transgenic approaches to opening up new fields of vasopressin and oxytocin research.

Submit: New GeneRIF Correction See all GeneRIFs (141)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables V1A vasopressin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurohypophyseal hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables oxytocin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxytocin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in drinking behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in grooming behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lactation	TAS Traceable Author Statement more info	PubMed
involved_in male mating behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal aggressive behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
involved_in parturition	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of female receptivity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hindgut contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of penile erection	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of prostaglandin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ether	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to external biotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to prostaglandin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm ejaculation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: oxytocin-neurophysin 1

Names: OT-NPI; oxcytocin; oxytocin, prepropeptide; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds; oxytocin/neurophysin 1 prepropeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.