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    Osbp oxysterol binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365410, updated on 9-Dec-2024

    Summary

    Official Symbol
    Osbpprovided by RGD
    Official Full Name
    oxysterol binding proteinprovided by RGD
    Primary source
    RGD:1308069
    See related
    EnsemblRapid:ENSRNOG00000021057 AllianceGenome:RGD:1308069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including phosphatidylinositol-4-phosphate binding activity; sterol binding activity; and sterol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein modification process; and positive regulation of secretory granule organization. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP (oxysterol binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 303.3), Heart (RPKM 238.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Osbp in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (218313455..218343263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (208888697..208918511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228395237..228425366)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PAT1 homolog 1, processing body mRNA decay factor Neighboring gene small nucleolar RNA SNORA32 Neighboring gene ribosomal protein L27A like 8 Neighboring gene small Cajal body-specific RNA 23 like 1 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 1 Neighboring gene transfer RNA lysine (anticodon UUU) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding  
    enables protein domain specific binding  
    enables sterol binding  
    enables sterol transfer activity  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in cell junction  
    located_in cell junction  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in perinuclear endoplasmic reticulum  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    oxysterol-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108927.2 → NP_001102397.1  oxysterol-binding protein 1

      See identical proteins and their annotated locations for NP_001102397.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I0C1, D4A9D8
      Related
      ENSRNOP00000061365.3, ENSRNOT00000065411.4
      Conserved Domains (3) summary
      pfam00169
      Location:3 → 56
      PH; PH domain
      pfam01237
      Location:293 → 662
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      218313455..218343263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085624.2 → XP_038941552.1  oxysterol-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam01237
      Location:148 → 523
      Oxysterol_BP; Oxysterol-binding protein
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