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    mlc-3 EF-hand domain-containing protein;Myosin, essential light chain [ Caenorhabditis elegans ]

    Gene ID: 175768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlc-3
    Official Full Name
    EF-hand domain-containing protein;Myosin, essential light chain
    Primary source
    WormBase:WBGene00003371
    Locus tag
    CELE_F09F7.2
    See related
    AllianceGenome:WB:WBGene00003371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Located in striated muscle myosin thick filament. Is expressed in body wall musculature; nervous system; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlc-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (5565025..5567382)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Neighboring gene DNA-directed RNA polymerase subunit beta Neighboring gene Nematode Specific Peptide family, group B Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Profiling of Caenorhabditis elegans proteins using two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight-mass spectrometry. Kaji H, et al. Electrophoresis, 2000 May. PMID 10870962
    2. Molecular genetics of nematode muscle. Anderson P. Annu Rev Genet, 1989. PMID 2694942
    3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    4. Codon usage in Caenorhabditis elegans: delineation of translational selection and mutational biases. Stenico M, et al. Nucleic Acids Res, 1994 Jul 11. PMID 8041603, Free PMC Article
    5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of muscle myosin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle myosin thick filament HDA PubMed 

    General protein information

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    Preferred Names
    EF-hand domain-containing protein;Myosin, essential light chain
    NP_001359961.1
    • Confirmed by transcript evidence
    NP_741145.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5565025..5567382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171128.8 → NP_741145.1  Myosin, essential light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53014
      UniProtKB/TrEMBL
      B6EU49
      Conserved Domains (2) summary
      pfam13499
      Location:9 → 70
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:90 → 142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001372589.2 → NP_001359961.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY79
      Conserved Domains (1) summary
      PTZ00184
      Location:10 → 43
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53014.1

    Gene LinkOut

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