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    pyk-2 Pyruvate kinase [ Caenorhabditis elegans ]

    Gene ID: 177984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pyk-2
    Official Full Name
    Pyruvate kinase
    Primary source
    WormBase:WBGene00014001
    Locus tag
    CELE_ZK593.1
    See related
    AllianceGenome:WB:WBGene00014001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in glycolytic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in intestine. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pyk-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10909913..10913078)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain;Transposase Neighboring gene ncRNA Neighboring gene High-affinity choline transporter 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension. Onken B, et al. PLoS Genet, 2020 Aug. PMID 32841230, Free PMC Article
    2. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
    3. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
    4. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
    5. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Pyruvate kinase
    NP_001255515.1
    • Confirmed by transcript evidence
    NP_001255516.1
    • Confirmed by transcript evidence
    NP_001255517.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10909913..10913078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268587.3 → NP_001255516.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT36
      Conserved Domains (2) summary
      cd00288
      Location:32 → 512
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:32 → 509
      pyruv_kin; pyruvate kinase

    2. NM_001268586.3 → NP_001255515.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23539
      Conserved Domains (2) summary
      cd00288
      Location:34 → 514
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:34 → 511
      pyruv_kin; pyruvate kinase

    3. NM_001268588.3 → NP_001255517.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT37
      Conserved Domains (2) summary
      cd00288
      Location:1 → 460
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:1 → 457
      pyruv_kin; pyruvate kinase
    Nucleotide Protein
    Heading Accession and Version

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