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Conserved domains on  [gi|392900628|ref|NP_001255515|]
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Pyruvate kinase [Caenorhabditis elegans]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 34-514 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 713.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSMEfAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKG 192
Cdd:cd00288   81 KDISLKAGDKFLVTTDPAAK-KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPV 432
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 433 PIITVSRDERISRQLHLHRGIFPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIV 512
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 392900628 513 VA 514
Cdd:cd00288  479 TV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 34-514 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 713.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSMEfAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKG 192
Cdd:cd00288   81 KDISLKAGDKFLVTTDPAAK-KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPV 432
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 433 PIITVSRDERISRQLHLHRGIFPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIV 512
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 392900628 513 VA 514
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 34-511 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 648.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628   34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnm 113
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  114 KEVQLENGKSVRVSTDPSMEfAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:TIGR01064  79 GEVKLKKGDKVIITTDDIKG-EGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:TIGR01064 158 NLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPV 432
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  433 PIITVSRDERISRQLHLHRGIFPVYypkgrIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG-WKQGAGFTNTMRI 511
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFL-----VDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 34-513 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 643.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 kEVQLENGKSVRVSTDpsmEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:COG0469   82 -PVELKKGDTFTLTTD---DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDG 273
Cdd:COG0469  158 NLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 274 VMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGD 353
Cdd:COG0469  238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 354 YPVEALAIMHNICKEAESAFFHMKHFEEliLHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVP 433
Cdd:COG0469  318 YPVEAVETMARIAEEAEKSLDYRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 434 IITVSRDERISRQLHLHRGIFPVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIV 512
Cdd:COG0469  396 ILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVH 469


                 .
gi 392900628 513 V 513
Cdd:COG0469  470 R 470
PRK05826 PRK05826
pyruvate kinase; Provisional
 34-497 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 550.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnm 113
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSMEfaATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:PRK05826  82 GKITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:PRK05826 240 GIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKptgMTHTTAIAAV-SATITCRAVAIILITTTGKTARLCSRYRPP 431
Cdd:PRK05826 320 KYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDR---IDEAIAMSAMyAANHLKGVKAIVALTESGRTARLISRFRPG 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392900628 432 VPIITVSRDERISRQLHLHRGIFPVYYPK-GRIDEWDVDVEervqygvNLGKTRGFIHLGDpLIVIT 497
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSaADTDDAAEEAL-------RLLLEKGLVESGD-LVVVT 455
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 34-379 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 550.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628   34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNM 113
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  114 KEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESC-EETAVICTIENGGALGTRKG 192
Cdd:pfam00224  82 KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|....*..
gi 392900628  353 DYPVEALAIMHNICKEAESAFFHMKHF 379
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPHRNLF 348
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 34-514 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 713.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSMEfAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKG 192
Cdd:cd00288   81 KDISLKAGDKFLVTTDPAAK-KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPV 432
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 433 PIITVSRDERISRQLHLHRGIFPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIV 512
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 392900628 513 VA 514
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 34-511 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 648.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628   34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnm 113
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  114 KEVQLENGKSVRVSTDPSMEfAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:TIGR01064  79 GEVKLKKGDKVIITTDDIKG-EGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:TIGR01064 158 NLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPV 432
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  433 PIITVSRDERISRQLHLHRGIFPVYypkgrIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG-WKQGAGFTNTMRI 511
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFL-----VDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 34-513 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 643.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 kEVQLENGKSVRVSTDpsmEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:COG0469   82 -PVELKKGDTFTLTTD---DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDG 273
Cdd:COG0469  158 NLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 274 VMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGD 353
Cdd:COG0469  238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 354 YPVEALAIMHNICKEAESAFFHMKHFEEliLHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVP 433
Cdd:COG0469  318 YPVEAVETMARIAEEAEKSLDYRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 434 IITVSRDERISRQLHLHRGIFPVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIV 512
Cdd:COG0469  396 ILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVH 469


                 .
gi 392900628 513 V 513
Cdd:COG0469  470 R 470
PRK05826 PRK05826
pyruvate kinase; Provisional
 34-497 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 550.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnm 113
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSMEfaATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:PRK05826  82 GKITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:PRK05826 240 GIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKptgMTHTTAIAAV-SATITCRAVAIILITTTGKTARLCSRYRPP 431
Cdd:PRK05826 320 KYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDR---IDEAIAMSAMyAANHLKGVKAIVALTESGRTARLISRFRPG 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392900628 432 VPIITVSRDERISRQLHLHRGIFPVYYPK-GRIDEWDVDVEervqygvNLGKTRGFIHLGDpLIVIT 497
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSaADTDDAAEEAL-------RLLLEKGLVESGD-LVVVT 455
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 34-379 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 550.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628   34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNM 113
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  114 KEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESC-EETAVICTIENGGALGTRKG 192
Cdd:pfam00224  82 KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|....*..
gi 392900628  353 DYPVEALAIMHNICKEAESAFFHMKHF 379
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPHRNLF 348
PLN02461 PLN02461
Probable pyruvate kinase
 31-494 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 519.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  31 QKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFA 110
Cdd:PLN02461  18 LRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 111 NNmKEVQLENGKSVRVSTDPSMEfaATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETA--VICTIENGGALG 188
Cdd:PLN02461  98 DG-KPVQLKQGQEITITTDYSIK--GDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAgtVRCRCENSAMLG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 189 TRKGVNLPGTIVDLPAVTSKDIEDLL-FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEI 267
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 268 IEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSG 347
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 348 ETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSR 427
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 428 YRPPVPIITV-------------SRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLI 494
Cdd:PLN02461 415 YRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 60-515 3.87e-179

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 511.13  E-value: 3.87e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  60 MNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmkEVQLENGKSVRVSTDPSMEFAATSS 139
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGG--EAVMERGATCYVTTDPAFADKGTKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 140 HIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVE 218
Cdd:PTZ00300  79 KFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEdEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 219 QGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLI 298
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 299 AKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKH 378
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 379 FEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYY 458
Cdd:PTZ00300 319 FNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392900628 459 PKGRIDEwDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVAT 515
Cdd:PTZ00300 399 DAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PRK06354 PRK06354
pyruvate kinase; Provisional
 34-515 9.04e-176

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 507.54  E-value: 9.04e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 kEVQLENGKSVRVSTDpsmEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETA--VICTIENGGALGTRK 191
Cdd:PRK06354  87 -PIELKTGDEFILTSR---EVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVLSNKK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 192 GVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEK-GKHIYIIAKIESEDGVTNCDEIIEA 270
Cdd:PRK06354 163 GVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNIDAILEL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 271 SDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETA 350
Cdd:PRK06354 243 CDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETA 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 351 KGDYPVEALAIMHNICKEAESAFFHMKhfeelILHTKKPTGMTHTTAI-AAVSAT-ITCRAVAIILITTTGKTARLCSRY 428
Cdd:PRK06354 323 AGDYPVEAVQTMATIAVRIEKDLPYRD-----ILSKRPEFTTTITNAIsQAVSHIaLQLDAAAIVTLTKSGATARNVSKY 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 429 RPPVPIITVSRDERISRQLHLHRGIFPVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDpLIVIT-GWKQG-AGFT 506
Cdd:PRK06354 398 RPKTPILAVTPNESVARRLQLVWGVTPLLVLD------APSTDETFDAAINVAQESGLLKQGD-LVVITaGTLVGeSGST 470


                 ....*....
gi 392900628 507 NTMRIVVAT 515
Cdd:PRK06354 471 DLMKVHVVG 479
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 26-512 3.60e-170

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 490.43  E-value: 3.60e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  26 ISERPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFP-VAIALDTKGPEI 104
Cdd:PTZ00066  30 ISDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNAnLGILLDTKGPEI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 105 RTGMFANNmKEVQLENGKSVRVSTDPSMEfaATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENG 184
Cdd:PTZ00066 110 RTGFLKNH-KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNN 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 185 GALGTRKGVNLPGTIVDLPAVTSKDIEDLL-FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTN 263
Cdd:PTZ00066 187 ATIGERKNMNLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLIN 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 264 CDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCV 343
Cdd:PTZ00066 267 FDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCV 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 344 MLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTAR 423
Cdd:PTZ00066 347 MLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTAR 426

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 424 LCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKgrIDEWDVDVEErvqyGVNLGKTRGFIHLGDPLIVITGWKQG- 502
Cdd:PTZ00066 427 LISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS--FQGTDVVIRN----AIALAKERGLVESGDSAIAVHGVKEEv 500

                        490
                 ....*....|
gi 392900628 503 AGFTNTMRIV 512
Cdd:PTZ00066 501 AGSSNLMKVV 510
PRK09206 PRK09206
pyruvate kinase PykF;
34-513 4.76e-168

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 483.40  E-value: 4.76e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  34 RKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNm 113
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 114 KEVQLENGKSVRVSTDPSmeFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGV 193
Cdd:PRK09206  81 NDVSLKAGQTFTFTTDKS--VVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 194 NLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGE-KGKHIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILEASD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAffhMKHFEELILHTKKptgMTHTTAIA--AVSATITCRAVAIILITTTGKTARLCSRYRP 430
Cdd:PRK09206 319 KYPLEAVSIMATICERTDRV---MNSRLESNNDNRK---LRITEAVCrgAVETAEKLDAPLIVVATQGGKSARSVRKYFP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 431 PVPIITVSRDERISRQLHLHRGIFPVYypkgrIDEWDvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMR 510
Cdd:PRK09206 393 DATILALTTNEKTARQLVLSKGVVPQL-----VKEIA-STDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTAS 466


                 ...
gi 392900628 511 IVV 513
Cdd:PRK09206 467 VHV 469
PRK06247 PRK06247
pyruvate kinase; Provisional
 33-511 9.41e-149

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 434.35  E-value: 9.41e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  33 TRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANn 112
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 113 mKEVQLENGKSVRVSTDpsmEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKG 192
Cdd:PRK06247  83 -GKVQLANGQTFRLDVD---DAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 193 VNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKgkhIYIIAKIESEDGVTNCDEIIEASD 272
Cdd:PRK06247 159 VSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEASD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKG 352
Cdd:PRK06247 236 AIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 353 DYPVEALAIMHNICKEAESAffhmKHFEELILHTKKPTGMTHTTAIAAVSATI--TCRAVAIILITTTGKTARLCSRYRP 430
Cdd:PRK06247 316 KYPVEAVRTMARIIRQVERD----PTYPPLIHAQRPQPEATKRDAISYAARDIaeRLDLAALVAYTSSGDTALRAARERP 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 431 PVPIITVSRDERISRQLHLHRGIFPVYYPKGRidewdvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTM 509
Cdd:PRK06247 392 PLPILALTPNPETARRLALTWGVHCVVVDDAR------DTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTNML 465


                 ..
gi 392900628 510 RI 511
Cdd:PRK06247 466 RI 467
PLN02765 PLN02765
pyruvate kinase
 36-512 2.90e-114

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 347.81  E-value: 2.90e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  36 TGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTgmfaNNMKE 115
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQV----INKTE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 116 --VQLENGKSVRVSTDPSMEfaATSSHIYADYRNLPKVVQPGSRIYIDDGLIS--------LIVESCEETAVICTIENGG 185
Cdd:PLN02765 106 kpISLKAGNTVTLTPDQSKE--ASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTVKNSA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 186 AL-GTRKGVNLPGTIVDLPAVTSKDIEDL-LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKH-IYIIAKIESEDGVT 262
Cdd:PLN02765 184 TLaGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSqTQIFAKIENVEGLT 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 263 NCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVIcATQMLESMITKPRPTRAECSDVANAVLDGVDC 342
Cdd:PLN02765 264 HFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGADA 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 343 VMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPtgMTHTTAIA--AVSATITCRAVAIILITTTGK 420
Cdd:PLN02765 343 ILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEP--MSHLESIAssAVRAAIKVKASVIIVFTSSGR 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 421 TARLCSRYRPPVPIITV-------------SRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERV-QYGVNLGKTRGF 486
Cdd:PLN02765 421 AARLIAKYRPTMPVLSVviprlktnqlkwsFTGAFQARQCLIVRGLFPMLADPRHSAESTSATNESVlKVALDHGKAAGV 500

                        490       500
                 ....*....|....*....|....*.
gi 392900628 487 IHLGDPLIVItgwkQGAGFTNTMRIV 512
Cdd:PLN02765 501 IKSHDRVVVC----QKVGDSSVVKII 522
PLN02623 PLN02623
pyruvate kinase
 29-501 1.83e-113

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 347.69  E-value: 1.83e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  29 RPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIRE-AAENAPFPVAIALDTKGPEIRTG 107
Cdd:PLN02623 105 KPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 108 MFAnnmKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNlpkVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGAL 187
Cdd:PLN02623 185 DLP---QPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVN---DVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGEL 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 188 GTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEI 267
Cdd:PLN02623 259 KSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSI 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 268 IEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSG 347
Cdd:PLN02623 339 ITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSG 418

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 348 ETAKGDYPVEALAIMHNICKEAESAFfhmkhFEELILHTKKPTGMTHTTAIAAVSATITCRAV--AIILITTTGKTARLC 425
Cdd:PLN02623 419 ETAHGKFPLKAVKVMHTVALRTEATL-----PEGTTPPNLGQAFKNHMSEMFAFHATMMANTLgtSIIVFTRTGFMAILL 493

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392900628 426 SRYRPPVPIITVSRDERISRQLHLHRGIFPVYYpkgridEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQ 501
Cdd:PLN02623 494 SHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYM------QFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQ 563
PRK06739 PRK06739
pyruvate kinase; Validated
 39-383 4.30e-96

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 295.32  E-value: 4.30e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  39 ICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENapfpVAIALDTKGPEIRTGMFANnmKEVQL 118
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----IKILGDVQGPKIRLGEIKG--EQITL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 119 ENGKSVRVSTDPsmeFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGT 198
Cdd:PRK06739  80 QAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 199 IVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHI-YIIAKIESEDGVTNCDEIIEASDGVMVA 277
Cdd:PRK06739 157 IVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 278 RGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVE 357
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316

                        330       340       350
                 ....*....|....*....|....*....|
gi 392900628 358 ALAIMHNICKEAES----AFFHMKHFEELI 383
Cdd:PRK06739 317 SVSTLRLVSEFAEHvkkdGPFVMKDVLELL 346
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 33-497 2.76e-93

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 293.19  E-value: 2.76e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  33 TRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFaNN 112
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL-GG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 113 MKEVQLENGK----SVRVSTDPSMEFAatsshIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALG 188
Cdd:PLN02762 103 ASSAKAEDGEewtfTVRKFDGSRPEFT-----IQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 189 TRKGVNL--PGTIVD-----LPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEK--GKHIYIIAKIESED 259
Cdd:PLN02762 178 PRANLTFwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLD 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 260 GVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDG 339
Cdd:PLN02762 258 SLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQR 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 340 VDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILH---TKKPTGMTHTTAIAAVSATITCRAVAIILIT 416
Cdd:PLN02762 338 ADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELPqlsSSLSDRISEEICNSAAKMANNLGVDAIFVYT 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 417 TTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVyypkgRIDEWDvDVEERVQYGVNLGKTRGFIHLGDPLIVI 496
Cdd:PLN02762 418 KHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPF-----RLDFSD-DMESNLNKTFSLLKARGMIKSGDLVIAV 491


                 .
gi 392900628 497 T 497
Cdd:PLN02762 492 S 492
PRK08187 PRK08187
pyruvate kinase; Validated
 30-365 2.24e-54

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 190.61  E-value: 2.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  30 PQKTRKTGVICTI-GPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGM 108
Cdd:PRK08187 129 RPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGA 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 109 FANNMKEVQLENGKSVRVSTDPSME------FAATSSH--IYADyrnlpkvVQPGSRIYIDDGLISLIVESCEETAVICT 180
Cdd:PRK08187 209 VAGPLGKTRLYTGDRLALVAQGPPRrideehFQVTCTLpeILAR-------LAVGARVWIDDGKLGARVERVGPGGALLE 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 181 IENGGALGTR----KGVNLPGTIVDLPAVTSKDIEDLLFGVEQGvDIIFASFIRNADGIHKIRQVLGEKG----KHIYII 252
Cdd:PRK08187 282 VTHARPKGLKlkpeKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRpddwRKLGLV 360

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 253 AKIESEDGVTNCDEIIEASDG-----VMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRA 327
Cdd:PRK08187 361 LKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRA 440

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 392900628 328 ECSDVANAvlDGVDCVMLSgetaKGDYPVEALAIMHNI 365
Cdd:PRK08187 441 EMTDAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
300-514 6.59e-44

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 157.75  E-value: 6.59e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 300 KCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHmkhf 379
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEY---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 380 EELILHTKKPTGMTHTTAIAAVSATITCR--AVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVY 457
Cdd:COG3848   77 REQRVPRAKESSTTITDAISHAVATTAADlgAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLL 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392900628 458 YPKGRidewdvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIVVA 514
Cdd:COG3848  157 VEESA------STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGvSGTTNLLKVHVV 208
PRK14725 PRK14725
pyruvate kinase; Provisional
 45-371 2.16e-42

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 159.73  E-value: 2.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  45 ACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGM---------------- 108
Cdd:PRK14725 151 AADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPiapgprviklrptrda 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 109 ----------------------------------------------------------------------------FANN 112
Cdd:PRK14725 231 lgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddegvlaegsqtayLANG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 113 MKeVQLENGKSVRVSTDPSME-------------------FAATSSHIYADYRN--LPKV---VQPGSRIYIDDGLISLI 168
Cdd:PRK14725 311 TL-LRLGRHDSTRVGGLPPVEqklrlkvgdrlvltrddapGDPAQGDAPPARISctLPEAfraARVGERVWFDDGKIGAV 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 169 VESCEETAVICTIENGGALGTR----KGVNLPGTIVDLPAVTSKDIEDLLFGVEQGvDIIFASFIRNADGIHKIRQVLGE 244
Cdd:PRK14725 390 VVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDALEK 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 245 -KGKHIYIIAKIESEDGVTNCDEII-EA----SDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESM 318
Cdd:PRK14725 469 lGADDLGVVLKIETRRAFENLPRILlEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESL 548

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 392900628 319 ITKPRPTRAECSDVANAVLdgVDCVMLSgetaKGDYPVEALAIMHNI-CKEAES 371
Cdd:PRK14725 549 AKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDIlRRMEEH 596
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 394-512 1.45e-34

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 125.67  E-value: 1.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  394 HTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKgridewDVDVEER 473
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 392900628  474 VQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIV 512
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
 198-305 6.78e-04

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 41.19  E-value: 6.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628  198 TIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVL-------GEKGKHIYIIAKIESEDGVTNCDEIIeA 270
Cdd:pfam03328  62 VVVRVNSLDSPFGKQDLAVLDLGAQVVLVPKVETAEDARAAVSAIryppkgiRRANGNTCLLAQIESALGVLNADEIA-A 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 392900628  271 SDGVM-VARG------DLGIEIPAE--KVFLAQKMLIAKCNLAG 305
Cdd:pfam03328 141 VEGVDgIFLGaedlsaDLGTLRSPGgpEVLYARERIVTAARAAG 184
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
211-309 1.08e-03

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 40.91  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900628 211 EDLLFGVEQGVDIIFASFIRNADGIHKIRQVL---GEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVAR-------GD 280
Cdd:COG2301   79 DDLAALVGAGLDGIVLPKVESAEDVRALAALLtelEAEGGSIPLMALIETARGLLNAAEIAAASPRVEALVfgaedlaAD 158

                         90       100       110
                 ....*....|....*....|....*....|..
gi 392900628 281 LGIEIPAEKVFLA---QKMLIAkCNLAGKPVI 309
Cdd:COG2301  159 LGARRTRDGDELLyarSRIVLA-ARAAGLAAI 189
HpcH COG3836
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
248-308 6.97e-03

2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];


Pssm-ID: 443047 [Multi-domain]  Cd Length: 237  Bit Score: 38.17  E-value: 6.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900628 248 HIYIIAKIESEDGVTNCDEIieAS----DGVMVARGDLGI------EIPAEKVFLAQKMLIAKCNLAGKPV 308
Cdd:COG3836  141 ETLVIVQIETAEAVENLDEI--AAvpgvDGVFIGPADLSAslghpgQPDHPEVQAAIERVIAAARAAGKPA 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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