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    nasp-2 Tetratricopeptide SHNi-TPR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nasp-2
    Official Full Name
    Tetratricopeptide SHNi-TPR domain-containing protein
    Primary source
    WormBase:WBGene00008218
    Locus tag
    CELE_C50B6.2
    See related
    AllianceGenome:WB:WBGene00008218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in CENP-A containing chromatin assembly and DNA replication-dependent chromatin assembly. Predicted to be active in nucleoplasm. Is expressed in germ line; intestine; and nervous system. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nasp-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (13310186..13312260, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Homeobox domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene DUF4817 domain-containing protein Neighboring gene DUF3452 domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans feed yolk to their young in a form of primitive lactation. Kern CC, et al. Nat Commun, 2021 Oct 5. PMID 34611154, Free PMC Article
    2. In vivo and transcriptome-wide identification of RNA binding protein target sites. Jungkamp AC, et al. Mol Cell, 2011 Dec 9. PMID 22152485, Free PMC Article
    3. The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Grote P, et al. Dev Cell, 2006 Oct. PMID 17011494
    4. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetratricopeptide SHNi-TPR domain-containing protein
    NP_506298.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13310186..13312260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073897.8 → NP_506298.1  Tetratricopeptide SHNi-TPR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17687
      Conserved Domains (2) summary
      pfam13424
      Location:376 → 453
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:379 → 416
      SHNi-TPR
    Nucleotide Protein
    Heading Accession and Version

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