Zbtb17 zinc finger and BTB domain containing 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb17provided by MGI
Official Full Name: zinc finger and BTB domain containing 17provided by MGI
Primary source: MGI:MGI:107410
See related: Ensembl:ENSMUSG00000006215 AllianceGenome:MGI:107410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lp-1; Miz1; mZ13; Zfp100
Summary: Enables DNA binding activity. Acts upstream of or within ectoderm development; gastrulation with mouth forming second; and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including cortical plate; early conceptus; genitourinary system; limb; and trunk somite. Orthologous to human ZBTB17 (zinc finger and BTB domain containing 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 15.8), thymus adult (RPKM 15.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 74.17 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141171984..141195248)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141444673..141467937)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.
Title: A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
Title: Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.
Title: The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.
Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
Title: Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
Title: Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
A functional Miz-1 is required for the development of T-acute lymphoblastic leukemia and B-acute lymphoblastic leukemia /lymphoma.
Title: Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
we report sustained Schwann cell proliferation caused by an increased expression of the direct Miz1 target gene Kdm8, encoding a H3K36me2 demethylase
Title: Miz1 Controls Schwann Cell Proliferation via H3K36(me2) Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination.
rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1, to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context.
Title: cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.
the Myc/Miz1 interaction is a defining hallmark of Sonic Hedgehog medulloblastomas development
Title: The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Title: Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC207589P1 (e-PCR)
- UniSTS:271965

PMC207589P2 (e-PCR)
- UniSTS:271966

PMC207589P3 (e-PCR)
- UniSTS:271967

PMC207589P4 (e-PCR)
- UniSTS:271968

RH124953 (e-PCR)
- UniSTS:161775

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 17

Names: polyomavirus late initiator promoter-binding protein; zfp-100; zinc finger protein 100; zinc finger protein 151; zinc finger protein Z13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378826.1 → NP_001365755.1 zinc finger and BTB domain-containing protein 17 isoform 2

Status: VALIDATED

Source sequence(s)

AL670285

UniProtKB/TrEMBL

A6H6B9

Related

ENSMUST00000142020.8

Conserved Domains (5) summary

COG5048
Location:322 → 653

COG5048; FOG: Zn-finger [General function prediction only]

PRK07003
Location:115 → 266

PRK07003; DNA polymerase III subunit gamma/tau

sd00017
Location:492 → 512

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:632 → 651

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18206
Location:2 → 113

BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)
NM_001378827.1 → NP_001365756.1 zinc finger and BTB domain-containing protein 17 isoform 3

Status: VALIDATED

Source sequence(s)

AL670285

UniProtKB/TrEMBL

A6H6B9

Conserved Domains (5) summary

COG3170
Location:16 → 118

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

COG5048
Location:221 → 552

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:391 → 411

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:531 → 550

ZF_C2H2; C2H2 Zn finger [structural motif]

cl38908
Location:1 → 37

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001378828.1 → NP_001365757.1 zinc finger and BTB domain-containing protein 17 isoform 1

Status: VALIDATED

Source sequence(s)

AL670285

UniProtKB/Swiss-Prot

A2ADB9, Q60699, Q60821

UniProtKB/TrEMBL

A6H6B9

Conserved Domains (5) summary

COG3170
Location:92 → 194

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

COG5048
Location:297 → 628

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:607 → 626

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18206
Location:2 → 113

BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)
NM_009541.2 → NP_033567.2 zinc finger and BTB domain-containing protein 17 isoform 1

See identical proteins and their annotated locations for NP_033567.2

Status: VALIDATED

Source sequence(s)

AK134251, BC145821, BY246264

Consensus CDS

CCDS18875.1

UniProtKB/Swiss-Prot

A2ADB9, Q60699, Q60821

UniProtKB/TrEMBL

A6H6B9

Related

ENSMUSP00000006377.7, ENSMUST00000006377.13

Conserved Domains (5) summary

COG3170
Location:92 → 194

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

COG5048
Location:297 → 628

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:607 → 626

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18206
Location:2 → 113

BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)