BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   2 DFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 81
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1820395196  82 LSLSPENVDDVLAVASFLQMQDIVTACHTLKS 113
Cdd:cd18206    81 LSLSPENVDDVLAVATFLQMQDIVTACHALKS 112

DNA polymerase III subunit gamma/tau;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196 115 AEPSSTTGESADASAVEGGDKRAKDEKAAATMLSRLDQA--RGSSSTGPGRELKEERGGQAESASSGPVPA-MEESPLAS 191
Cdd:PRK07003  387 AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAppAAPAPPATADRGDDAADGDAPVPAKANARAsADSRCDER 466

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820395196 192 GQSPNPASRPSSGAEQTEKADAPREPPPvelKPDPTSSMAAAEAEALSESSEQEMEVEPASKGEDGQEEEGAGPA 266
Cdd:PRK07003  467 DAQPPADSGSASAPASDAPPDAAFEPAP---RAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPA 538

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   2 DFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 81
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1820395196  82 LSLSPENVDDVLAVASFLQMQDIVTACHTLKS 113
Cdd:cd18206    81 LSLSPENVDDVLAVATFLQMQDIVTACHALKS 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   25 DCTFVVDGVDFKAHKAVLAACSEYFKMLFV-----DQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVASFL 99
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|
gi 1820395196  100 QMQDIVTACH 109
Cdd:smart00225  81 QIPGLVELCE 90

hypothetical protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFP--QHSQRVLEQLNQQRQLGLLCDCTFVV-DGVDFKAHKAVLAACSEYFKMLFV------DQKDVVHLDISNAAGLG 71
Cdd:PHA02713    1 MDIDdiKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTtpmiirDLVTRVNLQMFDKDAVK 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1820395196  72 QVLEFMYTAKlsLSPENVDDVLAVASFLQMQDIVTACHT 110
Cdd:PHA02713   81 NIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCES 117

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1820395196 432 KPYqCDYCGRSFSDptskMRHLETHDTDKEHKCPHCDKKFNQVGNLKAH-LKIH 484
Cdd:cd20908     1 KPW-CYYCDREFDD----EKILIQHQKAKHFKCHICHKKLYTAGGLAVHcLQVH 49

hypothetical protein

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1820395196 517 PYVCTHCQRQFADPGALQRHVRIHTGEKPCQcvICGKAFTQASSLIAHV 565
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSKVCP--VCGKEFRNTDSTLDHV 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   2 DFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 81
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAGLGQVLEFMYTAK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1820395196  82 LSLSPENVDDVLAVASFLQMQDIVTACHTLKS 113
Cdd:cd18206    81 LSLSPENVDDVLAVATFLQMQDIVTACHALKS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ---KDVVHL--DISNAAGLGQVLE 75
Cdd:cd18325     1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQldkRDIVHLnsDIVTAPAFSLLLE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1820395196  76 FMYTAKLSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18325    81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ---KDVVHL--DISNAAGLGQVLE 75
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQldkRDIVHLnsDIVTAPAFALLLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1820395196  76 FMYTAKLSLSPENVDDVLAVASFLQMQDIVTACHtlKSLAEPSSTTGES 124
Cdd:cd18324    81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCK--KKLKEKATTEADS 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   4 PQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV------DQKDVVHLDISNAAGLGQVLEFM 77
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCqvqktsDQATVTHLDIVTAQGFKAIIDFM 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1820395196  78 YTAKLSLSPENVDDVLAVASFLQMQDIVTACHTL 111
Cdd:cd18230    82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHNF 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLF---VDQKDVV--HLDISNAAGLGQVLE 75
Cdd:cd18323     1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYkeqLDKRDLVciNNEIVTAPAFSLLLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1820395196  76 FMYTAKLSLSPENVDDVLAVASFLQMQDIVTACH---TLKSLAEPSST 120
Cdd:cd18323    81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKkrlQARALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   3 FPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLF-----VDQKDVVHLDISNAAGLGQVLEFM 77
Cdd:cd18198     5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFtsgavVDQQNVYEIDFVSPEALTALLEFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1820395196  78 YTAKLSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18198    85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   4 PQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV-DQKDVVHLDISN----AAGLGQVLEFMY 78
Cdd:cd18192     2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFInHQHTTAQLNLSNmkisAECFDLILQFMY 81

                          90       100
                  ....*....|....*....|....*.
gi 1820395196  79 TAKLSLSPENVDDVLAVASFLQMQDI 104
Cdd:cd18192    82 LGKIMTAPSDFEQLKVAMNYLQLYYI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196  23 LCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV-----DQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVAS 97
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSsgmkeSSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                  ..
gi 1820395196  98 FL 99
Cdd:cd18186    81 KL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   25 DCTFVVDGVDFKAHKAVLAACSEYFKMLFV-----DQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVASFL 99
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|
gi 1820395196  100 QMQDIVTACH 109
Cdd:smart00225  81 QIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   3 FPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD------QKDVVHLDISNAAGLGQVLEF 76
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQnaketgQPTVATFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1820395196  77 MYTAKLSLSPENVDDVLAVASFLQMQDIVTACHT 110
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKT 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD------QKDVVHLDISNAAGLGQVLEFMYT 79
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHyiqdtgRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1820395196  80 AKLSLSPENVDDVLAVASFLQMQDIVTACHT 110
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKT 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKD---VVHL-DISNAAGLGQVLEFMYTAK 81
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTEndlVVSLpEEVTARGFGPLLQFAYTAK 93

                          90       100
                  ....*....|....*....|....*..
gi 1820395196  82 LSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18278    94 LLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD-----QKDVVHLDISNAAGLGQVLEFMYTA 80
Cdd:cd18264    11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytqesKARVIHLPVVSAAGLQRVLDFIYTS 90

                          90       100
                  ....*....|....*....|....*...
gi 1820395196  81 KLSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18264    91 WLSLSLDTLEDTLEAASYLQVTEAIGLC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   4 PQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLfVDQKDVVHLD--ISNAAGLGQVLEFMYTAK 81
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSL-VLHDNLIHLDqdMVSPTVFQQILDFIYTGK 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1820395196  82 LSLSPE---NVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18216    80 LLDSLFeepNLSEVLAAANYLQLPDLAALC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV-----DQKDVVHLDISNAAGLGQVLEFMYTA 80
Cdd:cd18261    11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSlcmveSEADEVNLHGVTSLGLKQALDFAYTG 90

                          90       100
                  ....*....|....*....|....*...
gi 1820395196  81 KLSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18261    91 QILLEPGVIQDVLAAGSHLQLLELLSLC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYF--KMLFVDQKDVVHLDISNAAGLGQVLEFMY 78
Cdd:cd18227     3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRRIVLPDVMNPRVFENILLSCY 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1820395196  79 TAKLSLSPENVDDVLAVASFLQMQDIVTACHTL 111
Cdd:cd18227    83 TGRLVLPAPEIVSYLTAASFLQMWHVVDKCTEL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDvVHLDIS-----NAAGLGQVLEFMYTA 80
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQAD-AELNITlpeevTVKGFEPLIQFAYTA 88

                          90       100
                  ....*....|....*....|....*...
gi 1820395196  81 KLSLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18277    89 KLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   1 MDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQK----DVVHLDIS-NAAGLGQVLE 75
Cdd:cd18331     2 IQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLkcnlSVINLDPEiNPEGFNILLD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1820395196  76 FMYTAKLSLSPENVDDVLAVASFLQMQDIVTACH 109
Cdd:cd18331    82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   3 FPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVdQKDVVHL--DISNAAGLGQVLEFMYTA 80
Cdd:cd18334     1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVL-HDNLINLdtDMVNPTVFRQILDFIYTG 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1820395196  81 KL----SLSPENVDDVLAVASFLQMQDIVTAC 108
Cdd:cd18334    80 KLltsdQPGEQNFNALLTAASYLQLHDLAALC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395196   6 HSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDV-VHLDISNAAGLGQVLEFMYTAKLSL 84
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGsVVLPESFAEVFGLLLDFFYTGELAL 80

                          90       100
                  ....*....|....*....|....*...
gi 1820395196  85 SPENVDDVLAVASFLQMQDIVTACHTLK 112
Cdd:cd18232    81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108