Kin Kin17 DNA and RNA binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kinprovided by MGI
Official Full Name: Kin17 DNA and RNA binding proteinprovided by MGI
Primary source: MGI:MGI:96676
See related: Ensembl:ENSMUSG00000037262 AllianceGenome:MGI:96676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kin17
Summary: Enables double-stranded DNA binding activity. Involved in DNA damage response and DNA replication. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; inner ear; limb; and midgut. Orthologous to human KIN (Kin17 DNA and RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 7.3) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 6.88 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (10085397..10097512)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (10080551..10092701)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This report demonstrates the importance of Kin17 as a critical factor that acts prior to the repair phase of DSB repair and is of bona fide importance for CSR.
Title: Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.
identification of KIN17 as a component of the human spliceosome indicate that this protein may participate in RNA processing
Title: KIN17 encodes an RNA-binding protein and is expressed during mouse spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA/RNA-binding protein KIN17

Names: KIN, antigenic determinant of recA protein homolog; antigenic determinant of rec-A protein; binding to curved DNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420343.1 → NP_001407272.1 DNA/RNA-binding protein KIN17 isoform 2

Status: VALIDATED

Source sequence(s)

AL772367
NM_001420344.1 → NP_001407273.1 DNA/RNA-binding protein KIN17 isoform 3

Status: VALIDATED

Source sequence(s)

AL772367
NM_025280.3 → NP_079556.1 DNA/RNA-binding protein KIN17 isoform 1

See identical proteins and their annotated locations for NP_079556.1

Status: VALIDATED

Source sequence(s)

AL772367

Consensus CDS

CCDS15676.1

UniProtKB/Swiss-Prot

Q8K339, Q9CV58

Related

ENSMUSP00000043614.8, ENSMUST00000042512.8

Conserved Domains (4) summary

smart00451
Location:25 → 54

ZnF_U1; U1-like zinc finger

cd13155
Location:337 → 390

KOW_KIN17; KOW_Kin17 is a RNA-binding motif

sd00020
Location:28 → 50

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam10357
Location:55 → 177

Kin17_mid; Domain of Kin17 curved DNA-binding protein