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Conserved domains on  [gi|33859684|ref|NP_079556|]
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DNA/RNA-binding protein KIN17 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 55-177 5.27e-73

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


:

Pssm-ID: 463057  Cd Length: 123  Bit Score: 223.52  E-value: 5.27e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33859684    55 LLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETP 134
Cdd:pfam10357   1 LLFGENPGKFIDEYSKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 33859684   135 KGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQV 177
Cdd:pfam10357  81 KGWFISYIDRSPEALARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 337-390 7.23e-27

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


:

Pssm-ID: 240519  Cd Length: 54  Bit Score: 101.07  E-value: 7.23e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33859684 337 PGKRVLVLNGGYRGNEGTLESINEKAFSATIVIETGPLKGRRVEGIQYEDISKL 390
Cdd:cd13155   1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 274-326 2.53e-21

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


:

Pssm-ID: 407963  Cd Length: 53  Bit Score: 86.25  E-value: 2.53e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33859684   274 RTDAWLQPGIVVKIITKKLGEKYHKKKGVVKEVIDRYTAVVKMTDSGDRLKLD 326
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 25-54 7.72e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 33.77  E-value: 7.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 33859684     25 RWYCQMCQKQCRDENGFKCHCMSESHQRQL 54
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
 
Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 55-177 5.27e-73

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


Pssm-ID: 463057  Cd Length: 123  Bit Score: 223.52  E-value: 5.27e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33859684    55 LLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETP 134
Cdd:pfam10357   1 LLFGENPGKFIDEYSKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 33859684   135 KGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQV 177
Cdd:pfam10357  81 KGWFISYIDRSPEALARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 337-390 7.23e-27

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


Pssm-ID: 240519  Cd Length: 54  Bit Score: 101.07  E-value: 7.23e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33859684 337 PGKRVLVLNGGYRGNEGTLESINEKAFSATIVIETGPLKGRRVEGIQYEDISKL 390
Cdd:cd13155   1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 274-326 2.53e-21

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


Pssm-ID: 407963  Cd Length: 53  Bit Score: 86.25  E-value: 2.53e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33859684   274 RTDAWLQPGIVVKIITKKLGEKYHKKKGVVKEVIDRYTAVVKMTDSGDRLKLD 326
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 25-54 7.72e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 33.77  E-value: 7.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 33859684     25 RWYCQMCQKQCRDENGFKCHCMSESHQRQL 54
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 26-50 8.46e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 33.62  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|....*
gi 33859684    26 WYCQMCQKQCRDENGFKCHCMSESH 50
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
 
Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 55-177 5.27e-73

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


Pssm-ID: 463057  Cd Length: 123  Bit Score: 223.52  E-value: 5.27e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33859684    55 LLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETP 134
Cdd:pfam10357   1 LLFGENPGKFIDEYSKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 33859684   135 KGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQV 177
Cdd:pfam10357  81 KGWFISYIDRSPEALARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 337-390 7.23e-27

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


Pssm-ID: 240519  Cd Length: 54  Bit Score: 101.07  E-value: 7.23e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33859684 337 PGKRVLVLNGGYRGNEGTLESINEKAFSATIVIETGPLKGRRVEGIQYEDISKL 390
Cdd:cd13155   1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 274-326 2.53e-21

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


Pssm-ID: 407963  Cd Length: 53  Bit Score: 86.25  E-value: 2.53e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33859684   274 RTDAWLQPGIVVKIITKKLGEKYHKKKGVVKEVIDRYTAVVKMTDSGDRLKLD 326
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 338-387 9.60e-07

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 45.29  E-value: 9.60e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 33859684 338 GKRVLVLNGGYRGNEGTLESINEKAFSATIVIETGPLKGRRveGIQYEDI 387
Cdd:cd00380   1 GDVVRVLRGPYKGREGVVVDIDPRFGIVTVKGATGSKGAEL--KVRFDDV 48
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 25-54 7.72e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 33.77  E-value: 7.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 33859684     25 RWYCQMCQKQCRDENGFKCHCMSESHQRQL 54
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 26-50 8.46e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 33.62  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|....*
gi 33859684    26 WYCQMCQKQCRDENGFKCHCMSESH 50
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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