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    Map6 microtubule-associated protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 17760, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map6provided by MGI
    Official Full Name
    microtubule-associated protein 6provided by MGI
    Primary source
    MGI:MGI:1201690
    See related
    Ensembl:ENSMUSG00000055407 AllianceGenome:MGI:1201690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STOP; Map-6; Mtap6; 2810411E12Rik
    Summary
    Enables microtubule binding activity. Predicted to be involved in several processes, including axonal transport of mitochondrion; dendrite morphogenesis; and positive regulation of axonogenesis. Predicted to be located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including Golgi-associated vesicle; cis-Golgi network; and microtubule. Is expressed in cortical plate; cranial ganglion; dorsal root ganglion; and sensory organ. Used to study schizophrenia. Orthologous to human MAP6 (microtubule associated protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 17.6), whole brain E14.5 (RPKM 16.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Map6 in Genome Data Viewer
    Location:
    7 E1; 7 54.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98916270..98986344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99266779..99337137)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WW domain containing adaptor with coiled-coil pseudogene Neighboring gene STARR-seq mESC enhancer starr_19646 Neighboring gene predicted gene, 34062 Neighboring gene predicted gene, 26705 Neighboring gene predicted gene, 40449 Neighboring gene STARR-seq mESC enhancer starr_19650 Neighboring gene serine (or cysteine) peptidase inhibitor, clade H, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4952 Neighboring gene STARR-positive B cell enhancer ABC_E1346 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_19652 Neighboring gene STARR-seq mESC enhancer starr_19653 Neighboring gene STARR-seq mESC enhancer starr_19654 Neighboring gene STARR-seq mESC enhancer starr_19655

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding  
    enables microtubule binding  
    enables microtubule binding PubMed 
    enables microtubule binding  
    Process Evidence Code Pubs
    involved_in axonal transport of mitochondrion  
    involved_in cytoskeleton-dependent intracellular transport  
    involved_in dendrite morphogenesis  
    involved_in dendrite morphogenesis  
    involved_in dendrite morphogenesis  
    involved_in lysosome localization  
    involved_in lysosome localization  
    involved_in microtubule cytoskeleton organization  
    involved_in positive regulation of axonogenesis  
    involved_in positive regulation of axonogenesis  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in Golgi-associated vesicle  
    is_active_in axon  
    located_in axon  
    located_in axon  
    is_active_in cis-Golgi network  
    is_active_in dendrite  
    located_in dendrite  
    located_in dendrite  
    is_active_in microtubule  
    located_in microtubule  
    located_in microtubule  
    located_in neuron projection  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in secretory vesicle  
    located_in transport vesicle membrane  

    General protein information

    Preferred Names
    microtubule-associated protein 6
    Names
    stable tubule-only polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043355.2NP_001036820.2  microtubule-associated protein 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' coding region, uses a downstream, in-frame start codon as described in PubMed: 14567673, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. These differences result in a shorter protein (isoform 3, also known as F-STOP) with shorter and distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC111120, AC158748
      Consensus CDS
      CCDS40029.1
      UniProtKB/Swiss-Prot
      Q7TSJ2
      Related
      ENSMUSP00000102717.3, ENSMUST00000107100.3
      Conserved Domains (1) summary
      pfam05217
      Location:224281
      STOP; STOP protein
    2. NM_001048167.1NP_001041632.1  microtubule-associated protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001041632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant(2) lacks an alternate in-frame exon in the 3' coding region and differs in the 3' UTR, compared to variant 1. This results in a shorter protein (isoform 2, also known as E-STOP) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC111120, AC158748
      Consensus CDS
      CCDS85345.1
      UniProtKB/TrEMBL
      D3Z6W1
      Related
      ENSMUSP00000146340.2, ENSMUST00000127492.2
      Conserved Domains (1) summary
      pfam05217
      Location:427521
      STOP; STOP protein
    3. NM_010837.3NP_034967.2  microtubule-associated protein 6 isoform 1

      See identical proteins and their annotated locations for NP_034967.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1), also known as N-STOP.
      Source sequence(s)
      AK018193, AK087413, BE951502, BE980868, BQ444318
      Consensus CDS
      CCDS21479.1
      UniProtKB/Swiss-Prot
      O55129, O70586, O70587, Q78DV4, Q78DV5, Q7TSJ2
      Related
      ENSMUSP00000146585.2, ENSMUST00000207883.2
      Conserved Domains (1) summary
      pfam05217
      Location:117185
      STOP; STOP protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      98916270..98986344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946412.2 RNA Sequence

    2. XR_869665.4 RNA Sequence

    3. XR_378220.5 RNA Sequence

    4. XR_869667.4 RNA Sequence

    5. XR_004934030.1 RNA Sequence

    6. XR_003946413.2 RNA Sequence

    7. XR_004934029.1 RNA Sequence

    8. XR_004934033.1 RNA Sequence

    9. XR_004934031.1 RNA Sequence

    10. XR_004934032.1 RNA Sequence

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