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    Xbp1 X-box binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22433, updated on 28-Jan-2025

    Summary

    Official Symbol
    Xbp1provided by MGI
    Official Full Name
    X-box binding protein 1provided by MGI
    Primary source
    MGI:MGI:98970
    See related
    Ensembl:ENSMUSG00000020484 AllianceGenome:MGI:98970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TREB5; XBP-1; TREB-5; D11Ertd39e
    Summary
    Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within cellular response to leukemia inhibitory factor; epithelial cell maturation; and exocrine pancreas development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeletal system. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 78.7), liver adult (RPKM 69.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Xbp1 in Genome Data Viewer
    Location:
    11 A1; 11 3.61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5470641..5475993)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5520641..5525993)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 3 Neighboring gene STARR-seq mESC enhancer starr_28426 Neighboring gene STARR-seq mESC enhancer starr_28427 Neighboring gene STARR-positive B cell enhancer ABC_E8384 Neighboring gene STARR-seq mESC enhancer starr_28430 Neighboring gene STARR-seq mESC enhancer starr_28431 Neighboring gene STARR-seq mESC enhancer starr_28432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5400351-5400552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5401062-5401263 Neighboring gene STARR-seq mESC enhancer starr_28434 Neighboring gene predicted gene 11963 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9357 Neighboring gene STARR-seq mESC enhancer starr_28436 Neighboring gene coiled-coil domain containing 117 Neighboring gene predicted gene, 22471

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables histone deacetylase binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables phosphatidylinositol 3-kinase regulatory subunit binding PubMed 
    enables protease binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein kinase binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-like protein ligase binding PubMed 
    Items 1 - 25 of 28
    Items 1 - 25 of 116
    Process Evidence Code Pubs
    involved_in adipose tissue development PubMed 
    involved_in angiogenesis PubMed 
    involved_in autophagy  
    involved_in cellular response to amino acid stimulus PubMed 
    involved_in cellular response to fluid shear stress  
    involved_in cellular response to fluid shear stress  
    involved_in cellular response to fructose stimulus PubMed 
    involved_in cellular response to glucose starvation PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to interleukin-4 PubMed 
    involved_in cellular response to laminar fluid shear stress  
    involved_in cellular response to laminar fluid shear stress  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to nutrient PubMed 
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to peptide hormone stimulus PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cholesterol homeostasis PubMed 
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in endoplasmic reticulum unfolded protein response  
    involved_in endothelial cell proliferation PubMed 
    involved_in endothelial cell proliferation  
    involved_in endothelial cell proliferation  
    acts_upstream_of_or_within epithelial cell maturation involved in salivary gland development PubMed 
    acts_upstream_of_or_within exocrine pancreas development PubMed 
    involved_in fatty acid homeostasis PubMed 
    acts_upstream_of_or_within glandular epithelial cell maturation PubMed 
    involved_in intracellular triglyceride homeostasis PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    involved_in lipid metabolic process  
    involved_in liver development PubMed 
    involved_in muscle organ development  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of SMAD protein signal transduction  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of endoplasmic reticulum unfolded protein response  
    involved_in negative regulation of endoplasmic reticulum unfolded protein response  
    involved_in negative regulation of myotube differentiation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in neuron development PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of B cell differentiation  
    involved_in positive regulation of B cell differentiation  
    involved_in positive regulation of MHC class II biosynthetic process  
    involved_in positive regulation of MHC class II biosynthetic process  
    involved_in positive regulation of T cell differentiation  
    involved_in positive regulation of T cell differentiation  
    involved_in positive regulation of TOR signaling  
    involved_in positive regulation of TOR signaling  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endoplasmic reticulum unfolded protein response  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of fat cell differentiation PubMed 
    involved_in positive regulation of hepatocyte proliferation PubMed 
    involved_in positive regulation of immunoglobulin production PubMed 
    involved_in positive regulation of immunoglobulin production  
    involved_in positive regulation of immunoglobulin production  
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of lactation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of plasma cell differentiation  
    involved_in positive regulation of plasma cell differentiation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vascular wound healing  
    involved_in positive regulation of vascular wound healing  
    involved_in protein destabilization PubMed 
    involved_in protein destabilization  
    involved_in protein destabilization  
    involved_in protein transport  
    involved_in regulation of autophagy PubMed 
    involved_in regulation of cell growth  
    involved_in regulation of cell growth  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to electrical stimulus  
    involved_in response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to insulin-like growth factor stimulus PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in serotonin secretion, neurotransmission  
    involved_in sterol homeostasis PubMed 
    involved_in transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    Items 1 - 25 of 116
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    X-box-binding protein 1
    Names
    tax-responsive element-binding protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271730.1NP_001258659.1  X-box-binding protein 1 isoform XBP1(S)

      See identical proteins and their annotated locations for NP_001258659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 26 nt segment in the CDS compared to variant 1, that causes a frameshift. The resulting isoform, XBP1(S), has the same N-terminus, but a longer and distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S) functions as a transcription factor.
      Source sequence(s)
      AL662876, BF453945, BG800705
      UniProtKB/TrEMBL
      A0A5F8MPD3
      Related
      ENSMUSP00000158915.3, ENSMUST00000239150.3
      Conserved Domains (1) summary
      cd14691
      Location:63119
      bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain
    2. NM_013842.3NP_038870.2  X-box-binding protein 1 isoform XBP1(U)

      See identical proteins and their annotated locations for NP_038870.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U).
      Source sequence(s)
      AK007724, AL662876, BF453945
      Consensus CDS
      CCDS24400.1
      UniProtKB/Swiss-Prot
      O35426, Q8VHM0, Q922G5, Q9ESS3
      Related
      ENSMUSP00000054852.10, ENSMUST00000063084.16
      Conserved Domains (3) summary
      cd14691
      Location:63119
      bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain
      pfam10998
      Location:191225
      DUF2838; Protein of unknown function (DUF2838)
      cl00057
      Location:30146
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5470641..5475993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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