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Gmeb2 glucocorticoid modulatory element binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 229004, updated on 27-Nov-2024

Summary

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Official Symbol
Gmeb2provided by MGI
Official Full Name
glucocorticoid modulatory element binding protein 2provided by MGI
Primary source
MGI:MGI:2652836
See related
Ensembl:ENSMUSG00000038705 AllianceGenome:MGI:2652836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in 1st branchial arch and heart. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 14.6), colon adult (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gmeb2 in Genome Data Viewer
Location:
2 H4; 2 103.63 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180893240..180933481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181251449..181288106, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4531 Neighboring gene fibronectin type III domain containing 11 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene helicase with zinc finger 2, transcriptional coactivator Neighboring gene proviral integration site 2 pseudogene Neighboring gene stathmin-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucocorticoid modulatory element-binding protein 2
Names
GMEB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419396.1 → NP_001406325.1  glucocorticoid modulatory element-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    AL845506
    UniProtKB/Swiss-Prot
    P58929, Q6PCY0

  2. NM_001419397.1 → NP_001406326.1  glucocorticoid modulatory element-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    AL845506
    UniProtKB/Swiss-Prot
    P58929, Q6PCY0

  3. NM_198169.3 → NP_937812.1  glucocorticoid modulatory element-binding protein 2

    See identical proteins and their annotated locations for NP_937812.1

    Status: VALIDATED

    Source sequence(s)
    AL845506
    Consensus CDS
    CCDS17206.1
    UniProtKB/Swiss-Prot
    P58929, Q6PCY0
    Related
    ENSMUSP00000037075.7, ENSMUST00000049032.13
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

RNA

  1. NR_185068.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845506

  2. NR_185069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845506

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180893240..180933481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239938.3 → XP_011238240.1  glucocorticoid modulatory element-binding protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011238240.1

    UniProtKB/TrEMBL
    Q6ZPV0
    Conserved Domains (1) summary
    cl02536
    Location:7 → 51
    SAND; SAND domain

  2. XM_006500604.3 → XP_006500667.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006500667.1

    UniProtKB/Swiss-Prot
    P58929, Q6PCY0
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

  3. XM_006500602.3 → XP_006500665.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006500665.1

    UniProtKB/Swiss-Prot
    P58929, Q6PCY0
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

  4. XM_006500605.4 → XP_006500668.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006500668.1

    UniProtKB/Swiss-Prot
    P58929, Q6PCY0
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58929.2 GenPept UniProtKB/Swiss-Prot:P58929

Gene LinkOut

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