Chst3 carbohydrate sulfotransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chst3provided by RGD
Official Full Name: carbohydrate sulfotransferase 3provided by RGD
Primary source: RGD:620355
See related: EnsemblRapid:ENSRNOG00000000572 AllianceGenome:RGD:620355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables proteoglycan sulfotransferase activity. Involved in chondroitin sulfate biosynthetic process and peripheral nervous system axon regeneration. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 106.6), Spleen (RPKM 46.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (28657308..28694976, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (28114386..28152046, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29731828..29768656, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chondroitin 6-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chondroitin 6-sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables chondroitin 6-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables chondroitin 6-sulfotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables proteoglycan sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables proteoglycan sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables proteoglycan sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sulfur compound metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 3

Names: C6ST-1; GST-0; carbohydrate (chondroitin 6) sulfotransferase 3; carbohydrate (chondroitin 6/keratan) sulfotransferase 3; chondroitin 6-O-sulfotransferase 1; chondroitin 6-sulfotransferase 3; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0

NP_445860.3

EC 2.8.2.17

EC 2.8.2.21

XP_038955055.1

EC 2.8.2.17

EC 2.8.2.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053408.3 → NP_445860.3 carbohydrate sulfotransferase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q9QZL2

Related

ENSRNOP00000000697.2, ENSRNOT00000000697.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

28657308..28694976 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099127.2 → XP_038955055.1 carbohydrate sulfotransferase 3 isoform X1

UniProtKB/Swiss-Prot

Q9QZL2

UniProtKB/TrEMBL

A6K3W8, F1LN90

Conserved Domains (1) summary

pfam00685
Location:269 → 453

Sulfotransfer_1; Sulfotransferase domain