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    Pip prolactin induced protein [ Mus musculus (house mouse) ]

    Gene ID: 18716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pipprovided by MGI
    Official Full Name
    prolactin induced proteinprovided by MGI
    Primary source
    MGI:MGI:102696
    See related
    Ensembl:ENSMUSG00000058499 AllianceGenome:MGI:102696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP17; SMGP; GCDFP-15
    Summary
    Predicted to enable IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Acts upstream of or within regulation of immune system process. Located in apical plasma membrane and extracellular region. Is expressed in several structures, including exocrine system and female reproductive system. Orthologous to human PIP (prolactin induced protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Pip in Genome Data Viewer
    Location:
    6 B2.1; 6 20.05 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41824483..41828999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41847549..41852065)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38796 Neighboring gene STARR-seq mESC enhancer starr_15706 Neighboring gene STARR-seq mESC enhancer starr_15707 Neighboring gene olfactory receptor family 9 subfamily A member 2 Neighboring gene STARR-seq mESC enhancer starr_15708 Neighboring gene seminal vesicle antigen-like 2 Neighboring gene seminal vesicle antigen-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgG binding  
    enables aspartic-type endopeptidase activity  
    enables aspartic-type endopeptidase activity  
    enables identical protein binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in nucleus  

    General protein information

    Preferred Names
    prolactin-inducible protein homolog
    Names
    14 kDa submandibular gland protein
    gross cystic disease fluid protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008843.4NP_032869.2  prolactin-inducible protein homolog precursor

      See identical proteins and their annotated locations for NP_032869.2

      Status: VALIDATED

      Source sequence(s)
      AK138795, CK616212
      Consensus CDS
      CCDS39469.1
      UniProtKB/Swiss-Prot
      P02816, Q64013, Q8K127, Q9QUG8
      UniProtKB/TrEMBL
      Q3UU48
      Related
      ENSMUSP00000074818.8, ENSMUST00000075351.10
      Conserved Domains (1) summary
      pfam05326
      Location:1126
      SVA; Seminal vesicle autoantigen (SVA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41824483..41828999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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