wdr46 WD repeat domain 46 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr46provided by ZNC
Official Full Name: WD repeat domain 46provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1264
See related: Ensembl:ENSDARG00000095879 AllianceGenome:ZFIN:ZDB-GENE-040426-1264
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bing4; c6orf11l; zgc:63793; Bing4-like
Summary: Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and segmental plate. Orthologous to human WDR46 (WD repeat domain 46). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (53081126..53096754)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (53202547..53218175)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200623.1 → NP_956917.1 WD repeat-containing protein 46

See identical proteins and their annotated locations for NP_956917.1

Status: PROVISIONAL

Source sequence(s)

BC056828

UniProtKB/TrEMBL

Q6PGU5

Related

ENSDARP00000122824.2, ENSDART00000143009.3

Conserved Domains (4) summary

COG2319
Location:172 → 370

WD40; WD40 repeat [General function prediction only]

pfam08149
Location:407 → 484

BING4CT; BING4CT (NUC141) domain

sd00039
Location:169 → 202

7WD40; WD40 repeat [structural motif]

cl02567
Location:169 → 390

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...