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Conserved domains on  [gi|41055048|ref|NP_956917|]
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WD repeat-containing protein 46 [Danio rerio]

Protein Classification

WDR46/Utp7 family protein( domain architecture ID 11456818)

WDR46/Utp7 family protein is a WD40 repeat domain-containing protein, similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 407-484 1.50e-46

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 462375  Cd Length: 79  Bit Score: 157.62  E-value: 1.50e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055048   407 PYMAHRLRG-QVCGVAYCPFEDVLGIGHGQGFTSMIVPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLD 484
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
151-359 5.43e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 5.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 151 DITSGAKYFNLHLSQFGPYRLDYSRTGRHLLLGGRRGHVACFDWQTKHLMCEMNV-METVNDIKWLHTEAMFAVA-QKKW 228
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 229 LYIYD-SKGVEFHCIKKFND-VLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGH 306
Cdd:COG2319 270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 41055048 307 TSGTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIR 359
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 407-484 1.50e-46

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 157.62  E-value: 1.50e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055048   407 PYMAHRLRG-QVCGVAYCPFEDVLGIGHGQGFTSMIVPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLD 484
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 407-485 2.06e-44

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 152.00  E-value: 2.06e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048    407 PYMAHRLRG-QVCGVAYCPFEDVLGIGHGQGFTSMIVPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLDP 485
Cdd:smart01033   1 PYMTHGLPGsRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
151-359 5.43e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 5.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 151 DITSGAKYFNLHLSQFGPYRLDYSRTGRHLLLGGRRGHVACFDWQTKHLMCEMNV-METVNDIKWLHTEAMFAVA-QKKW 228
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 229 LYIYD-SKGVEFHCIKKFND-VLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGH 306
Cdd:COG2319 270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 41055048 307 TSGTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIR 359
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-357 9.51e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 9.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 171 LDYSRTGrHLLLGGRRGHVACFdWQTKHLMCEMNV---METVNDIKWLHTEAMFAVA-QKKWLYIYDSKgvEFHCIKKF- 245
Cdd:cd00200  99 VAFSPDG-RILSSSSRDKTIKV-WDVETGKCLTTLrghTDWVNSVAFSPDGTFVASSsQDGTIKLWDLR--TGKCVATLt 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 246 ---NDVLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQKEPL 322
Cdd:cd00200 175 ghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254

                       170       180       190
                ....*....|....*....|....*....|....*
gi 41055048 323 VKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
319-357 6.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 6.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41055048   319 KEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 318-357 7.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41055048    318 QKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 309-433 9.03e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 9.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 309 GTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAFKPF-----HSSFLpagaSCLSLSQ-RG 382
Cdd:cd00200  31 GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVrtltgHTSYV----SSVAFSPdGR 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 41055048 383 LLSAATGD-VVQVYQnvwgstpVSKPYMAHRLRGQ---VCGVAYCPFEDVLGIGH 433
Cdd:cd00200 107 ILSSSSRDkTIKVWD-------VETGKCLTTLRGHtdwVNSVAFSPDGTFVASSS 154
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 407-484 1.50e-46

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 157.62  E-value: 1.50e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055048   407 PYMAHRLRG-QVCGVAYCPFEDVLGIGHGQGFTSMIVPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLD 484
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 407-485 2.06e-44

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 152.00  E-value: 2.06e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048    407 PYMAHRLRG-QVCGVAYCPFEDVLGIGHGQGFTSMIVPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLDP 485
Cdd:smart01033   1 PYMTHGLPGsRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
151-359 5.43e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 5.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 151 DITSGAKYFNLHLSQFGPYRLDYSRTGRHLLLGGRRGHVACFDWQTKHLMCEMNV-METVNDIKWLHTEAMFAVA-QKKW 228
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 229 LYIYD-SKGVEFHCIKKFND-VLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGH 306
Cdd:COG2319 270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 41055048 307 TSGTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIR 359
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-357 9.51e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 9.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 171 LDYSRTGrHLLLGGRRGHVACFdWQTKHLMCEMNV---METVNDIKWLHTEAMFAVA-QKKWLYIYDSKgvEFHCIKKF- 245
Cdd:cd00200  99 VAFSPDG-RILSSSSRDKTIKV-WDVETGKCLTTLrghTDWVNSVAFSPDGTFVASSsQDGTIKLWDLR--TGKCVATLt 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 246 ---NDVLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQKEPL 322
Cdd:cd00200 175 ghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254

                       170       180       190
                ....*....|....*....|....*....|....*
gi 41055048 323 VKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
134-424 1.67e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 134 DGEDTCTIAQDDIADAVDITSGAKYFNLHLSQFGPYRLDYSRTGRHLLLGGRRGHVACFDWQTKHLmcemnvmetvndIK 213
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL------------LR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 214 WL--HTEAMFAVA---QKKWL---------YIYDSKGVEfhCIKKF----NDVLRMQFLPYHFLLATASATGFLQYLDVS 275
Cdd:COG2319 157 TLtgHSGAVTSVAfspDGKLLasgsddgtvRLWDLATGK--LLRTLtghtGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 276 IGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKV 355
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41055048 356 YDIRAFKPFHS-SFLPAGASCLSLSQRG--LLSAATGDVVQVYQnvWGSTPVSKPYMAHrlRGQVCGVAYCP 424
Cdd:COG2319 315 WDLATGKLLRTlTGHTGAVRSVAFSPDGktLASGSDDGTVRLWD--LATGELLRTLTGH--TGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-424 2.95e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 2.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 248 VLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQKEPLVKMLC 327
Cdd:cd00200  54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 328 HRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAFKPFHS-----------SFLPAGASCLSLSQRG---LLSAATGDVVQ 393
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATltghtgevnsvAFSPDGEKLLSSSSDGtikLWDLSTGKCLG 213

                       170       180       190
                ....*....|....*....|....*....|.
gi 41055048 394 VYQnvwgstpvskpymAHrlRGQVCGVAYCP 424
Cdd:cd00200 214 TLR-------------GH--ENGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-363 2.47e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 2.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 169 YRLDYSRTGRHLLLGGRRGHVACFDWQTKHLMCEMNVME-TVNDIKWL-HTEAMFAVAQKKWLYIYDSKGVEfhCIKKF- 245
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgPVRDVAASaDGTYLASGSSDKTIRLWDLETGE--CVRTLt 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 246 ---NDVLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAII-------------------- 302
Cdd:cd00200  91 ghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVasssqdgtiklwdlrtgkcv 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 303 --HLGHTS--------------------GTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRA 360
Cdd:cd00200 171 atLTGHTGevnsvafspdgekllssssdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250


                ...
gi 41055048 361 FKP 363
Cdd:cd00200 251 GEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
247-424 1.78e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 247 DVLRMQFLPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQKEPLVKML 326
Cdd:COG2319  38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 327 CHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAFKPFHSSFLPAGA-SCLSLSQRG--LLSAATGDVVQVYqNVWGSTP 403
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAvTSVAFSPDGklLASGSDDGTVRLW-DLATGKL 196

                       170       180
                ....*....|....*....|....
gi 41055048 404 VskpymaHRLRG---QVCGVAYCP 424
Cdd:COG2319 197 L------RTLTGhtgAVRSVAFSP 214
WD40 pfam00400
WD domain, G-beta repeat;
319-357 6.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 6.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41055048   319 KEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 318-357 7.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41055048    318 QKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYD 357
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 309-433 9.03e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 9.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 309 GTVSLWSPNQKEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAFKPF-----HSSFLpagaSCLSLSQ-RG 382
Cdd:cd00200  31 GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVrtltgHTSYV----SSVAFSPdGR 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 41055048 383 LLSAATGD-VVQVYQnvwgstpVSKPYMAHRLRGQ---VCGVAYCPFEDVLGIGH 433
Cdd:cd00200 107 ILSSSSRDkTIKVWD-------VETGKCLTTLRGHtdwVNSVAFSPDGTFVASSS 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-422 2.01e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055048 328 HRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAFKPF-----HSSFLPAGASCLSLSQrgLLSAATGDVVQVYqnvwgst 402
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtlkgHTGPVRDVAASADGTY--LASGSSDKTIRLW------- 78

                        90       100
                ....*....|....*....|...
gi 41055048 403 PVSKPYMAHRLRG---QVCGVAY 422
Cdd:cd00200  79 DLETGECVRTLTGhtsYVSSVAF 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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