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    cars1 cysteinyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 368284, updated on 12-Jan-2025

    Summary

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    Official Symbol
    cars1provided by ZNC
    Official Full Name
    cysteinyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030328-29
    See related
    Ensembl:ENSDARG00000036164 AllianceGenome:ZFIN:ZDB-GENE-030328-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cars; sb:cb71
    Summary
    Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in cytoplasm. Is expressed in several structures, including hatching gland; immature eye; nervous system; pectoral fin; and polster. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cars1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (31796234..31830985, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (31525084..31559893, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene uncharacterized LOC137496176 Neighboring gene nucleosome assembly protein 1-like 4b Neighboring gene myosin binding protein C3 Neighboring gene lin-7 homolog C (C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Beckwith-Wiedemann syndrome region in vertebrates. Paulsen M, et al. Genome Res, 2005 Jan. PMID 15590939, Free PMC Article
    2. Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. Wang F, et al. Sci Rep, 2015 Aug 17. PMID 26278626, Free PMC Article
    3. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Zhang F, et al. Cell Discov, 2021 Oct 26. PMID 34697290, Free PMC Article
    4. Expression of nucleosome assembly protein 1 like genes in zebrafish embryos. Sun S, et al. Gene Expr Patterns, 2020 Jan. PMID 31669493
    5. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cysteinyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine--tRNA ligase, cytoplasmic
    NP_001112372.1
    XP_005168916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001118900.1 → NP_001112372.1  cysteine--tRNA ligase, cytoplasmic

      Status: PROVISIONAL

      Source sequence(s)
      AL935207
      UniProtKB/TrEMBL
      A0A8M1NI72, E7FDV9
      Related
      ENSDARP00000052513.6, ENSDART00000052514.8
      Conserved Domains (3) summary
      cd00672
      Location:108 → 523
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      cd10310
      Location:2 → 74
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:85 → 822
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      31796234..31830985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168859.5 → XP_005168916.1  cysteine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGP2, E7FGP2
      Related
      ENSDARP00000112444.2, ENSDART00000129720.5
      Conserved Domains (2) summary
      cd00672
      Location:29 → 444
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:7 → 743
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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