|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
7-743 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 831.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 7 AAKGKRVQPPWSPP--EGTDISKLRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYF 84
Cdd:PTZ00399 17 GQVSKSRLPEWKKPskEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 85 KYDVFYCMNITDIDDKIIKRARQNYLleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgp 164
Cdd:PTZ00399 97 GYDVFYVMNITDIDDKIIKRAREEKL------------------------------------------------------ 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 165 lqvavqskaaqdsiqkqaqvlleeakdllsdwldsqfgsqvtenSIFSLLPKYWEGEYHKDMEALNVLPPDVLTRVSEYV 244
Cdd:PTZ00399 123 --------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYV 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 245 PEIVEFVKKIVDNGYGYESNGSVYFDTAKFDScPAHSYAKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSQNDFALWKA 324
Cdd:PTZ00399 159 PEIVDFIQKIIDNGFAYESNGSVYFDVEAFRK-AGHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDFALWKA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 325 SKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFENDYWVRYFLHTGHLTIAGC 404
Cdd:PTZ00399 235 SKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGL 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 405 KMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKDTLDYSNNTMESAIQYERFINEFFLNVKDILRspTDITGQYEKWEA 484
Cdd:PTZ00399 315 KMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLR--ESELTSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 485 EEIELNKCFYDKKTSVHGALCDNIDTRSALEEMRALVGQSNTYMAARRSAKLPpnrmLLQSIALYLTDMLKTFGAIEGTD 564
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQPSAP----LLRSVAQYVTKILSIFGLVEGSD 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 565 piGFPVGGNGQSadlESTVMPYLSVLSDFREDVRKIAR--------EKKVTELLQLCDQLRDDTLPELGVRLEDRDGLPT 636
Cdd:PTZ00399 469 --GLGSQGQNST---SENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPS 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 637 SVKLVDKETLLKEKEEKKKLKDDKRKKKEEAARKKQEQEMAKLAKMKLKPSEMFRSETDKYSSFDETGFPTHDAEGKELS 716
Cdd:PTZ00399 544 VWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDETGLPTHDADGEEIS 623
|
730 740
....*....|....*....|....*..
gi 528485085 717 KGLTKKLRKLYETQEKLHNEYLQSTQN 743
Cdd:PTZ00399 624 KKERKKLSKEYDKQAKLHEEYLAKGGK 650
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
28-633 |
3.40e-163 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 479.21 E-value: 3.40e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARq 107
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 108 nylleqyREKKPSAAqilqdvLTARTpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlle 187
Cdd:COG0215 80 -------EEGESIWE------LAERY------------------------------------------------------ 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 188 eakdllsdwldsqfgsqvtensifsllpkywEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYESNGSV 267
Cdd:COG0215 93 -------------------------------IAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 268 YFDTAKFdscpaHSYAKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSQNDFALWKASKPGEPSWDSPWGMGRPGWH 344
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 345 IECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHT 424
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAAT-GKPFARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 425 ARQLRLAFLMHSWKDTLDYSNNTMESAIQ-YERfINEFFLNVKDILRSPTDITGQYEKWEAEeielnkcFYDkktsvhgA 503
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEELREE-------FIA-------A 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 504 LCDNIDTRSALEEMRALVGQSNTYMAARRSAKlppnrmLLQSIALYLTDMLKTFGaIEGTDPIGFpvGGNGQSADLESTV 583
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREINKALDEGEDKA------ALAALAALLRALGGVLG-LLLLEPEAW--QGAAEDELLDALI 420
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 528485085 584 MPYLsvlsdfreDVRKIAREKKvteLLQLCDQLRDDtLPELGVRLED-RDG 633
Cdd:COG0215 421 EALI--------EERAEARKAK---DFARADRIRDE-LAALGIVLEDtPDG 459
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
28-631 |
2.86e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 420.25 E-value: 2.86e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARQ 107
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 108 NYLLEQyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlle 187
Cdd:TIGR00435 80 NGESVY-------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 188 eakdllsdwldsqfgsQVTENSIfsllpkyweGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYES-NGS 266
Cdd:TIGR00435 86 ----------------EVSERFI---------EAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 267 VYFDTAKFDScpahsYAKLvpeAVGDQKALQEGEGDLSISAdrlseKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIE 346
Cdd:TIGR00435 141 VYFDVSKFKD-----YGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 347 CSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTAR 426
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 427 QLRLAFLMHSWKDTLDYSNNTMESA-IQYERFINEffLNVKDilrspTDITGQYEkWEAEEIELNKCFYDkktSVHGALC 505
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFSEELLEAAkNALERLYKA--LRVLD-----TSLAYSGN-QSLNKFPDEKEFEA---RFVEAMD 355
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 506 DNIDTRSALEEMRALVGQSNTYMA--ARRSAKLPPnrmlLQSIALYLTDMLKtfgaiegtDPIGF-PVGGNGQSADLEST 582
Cdd:TIGR00435 356 DDLNTANALAVLFELAKSINLTFVskADAALLIEH----LIFLESRLGLLLG--------LPSKPvQAGSNDDLGEIEAL 423
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 528485085 583 VMPylsvlsdfredvRKIAREKKVtelLQLCDQLRDDtLPELGVRLEDR 631
Cdd:TIGR00435 424 IEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDT 456
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
41-454 |
1.84e-138 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 409.45 E-value: 1.84e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 41 FVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARQNYLleqyrekkps 120
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGE---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 121 aaqilqdvltartPFKAklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlleeakdllsdwldsq 200
Cdd:pfam01406 71 -------------SFRQ--------------------------------------------------------------- 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 201 fgsqvtensifslLPKYWEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYES-NGSVYFDTAKFdscpa 279
Cdd:pfam01406 75 -------------LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 280 HSYAKLVPEAVGDQKALQEGEGDlsisadrlSEKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESM 359
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 360 DIHGGGFDLRFPHHDNELAQSEAYFENDyWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKD 439
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*
gi 528485085 440 TLDYSnntmESAIQY 454
Cdd:pfam01406 288 PLDFS----EELLEQ 298
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
29-444 |
1.71e-111 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 336.47 E-value: 1.71e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 29 RLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYFkYDVFYCMNITDIDDKIIKRARQN 108
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 109 YLleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvllee 188
Cdd:cd00672 80 GL------------------------------------------------------------------------------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 189 akdllsDWLDsqfgsqvtensifslLPKYWEGEYHKDMEALNVLPPDVLTRVseyvpeivefvkkivdngygyesngsvy 268
Cdd:cd00672 82 ------SWKE---------------VADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 269 fdtakfdscpahsyaklvpeavgdqkalqegegdlsisadrlsekrsqndfalwkaskpgepswdspwgmgrpgWHIECS 348
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 349 AMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQL 428
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 528485085 429 RLAFLMHSWKDTLDYS 444
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
7-743 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 831.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 7 AAKGKRVQPPWSPP--EGTDISKLRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYF 84
Cdd:PTZ00399 17 GQVSKSRLPEWKKPskEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 85 KYDVFYCMNITDIDDKIIKRARQNYLleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgp 164
Cdd:PTZ00399 97 GYDVFYVMNITDIDDKIIKRAREEKL------------------------------------------------------ 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 165 lqvavqskaaqdsiqkqaqvlleeakdllsdwldsqfgsqvtenSIFSLLPKYWEGEYHKDMEALNVLPPDVLTRVSEYV 244
Cdd:PTZ00399 123 --------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYV 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 245 PEIVEFVKKIVDNGYGYESNGSVYFDTAKFDScPAHSYAKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSQNDFALWKA 324
Cdd:PTZ00399 159 PEIVDFIQKIIDNGFAYESNGSVYFDVEAFRK-AGHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDFALWKA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 325 SKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFENDYWVRYFLHTGHLTIAGC 404
Cdd:PTZ00399 235 SKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGL 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 405 KMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKDTLDYSNNTMESAIQYERFINEFFLNVKDILRspTDITGQYEKWEA 484
Cdd:PTZ00399 315 KMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLR--ESELTSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 485 EEIELNKCFYDKKTSVHGALCDNIDTRSALEEMRALVGQSNTYMAARRSAKLPpnrmLLQSIALYLTDMLKTFGAIEGTD 564
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQPSAP----LLRSVAQYVTKILSIFGLVEGSD 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 565 piGFPVGGNGQSadlESTVMPYLSVLSDFREDVRKIAR--------EKKVTELLQLCDQLRDDTLPELGVRLEDRDGLPT 636
Cdd:PTZ00399 469 --GLGSQGQNST---SENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPS 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 637 SVKLVDKETLLKEKEEKKKLKDDKRKKKEEAARKKQEQEMAKLAKMKLKPSEMFRSETDKYSSFDETGFPTHDAEGKELS 716
Cdd:PTZ00399 544 VWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDETGLPTHDADGEEIS 623
|
730 740
....*....|....*....|....*..
gi 528485085 717 KGLTKKLRKLYETQEKLHNEYLQSTQN 743
Cdd:PTZ00399 624 KKERKKLSKEYDKQAKLHEEYLAKGGK 650
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
28-633 |
3.40e-163 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 479.21 E-value: 3.40e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARq 107
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 108 nylleqyREKKPSAAqilqdvLTARTpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlle 187
Cdd:COG0215 80 -------EEGESIWE------LAERY------------------------------------------------------ 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 188 eakdllsdwldsqfgsqvtensifsllpkywEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYESNGSV 267
Cdd:COG0215 93 -------------------------------IAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 268 YFDTAKFdscpaHSYAKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSQNDFALWKASKPGEPSWDSPWGMGRPGWH 344
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 345 IECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHT 424
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAAT-GKPFARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 425 ARQLRLAFLMHSWKDTLDYSNNTMESAIQ-YERfINEFFLNVKDILRSPTDITGQYEKWEAEeielnkcFYDkktsvhgA 503
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEELREE-------FIA-------A 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 504 LCDNIDTRSALEEMRALVGQSNTYMAARRSAKlppnrmLLQSIALYLTDMLKTFGaIEGTDPIGFpvGGNGQSADLESTV 583
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREINKALDEGEDKA------ALAALAALLRALGGVLG-LLLLEPEAW--QGAAEDELLDALI 420
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 528485085 584 MPYLsvlsdfreDVRKIAREKKvteLLQLCDQLRDDtLPELGVRLED-RDG 633
Cdd:COG0215 421 EALI--------EERAEARKAK---DFARADRIRDE-LAALGIVLEDtPDG 459
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
28-631 |
2.86e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 420.25 E-value: 2.86e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARQ 107
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 108 NYLLEQyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlle 187
Cdd:TIGR00435 80 NGESVY-------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 188 eakdllsdwldsqfgsQVTENSIfsllpkyweGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYES-NGS 266
Cdd:TIGR00435 86 ----------------EVSERFI---------EAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 267 VYFDTAKFDScpahsYAKLvpeAVGDQKALQEGEGDLSISAdrlseKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIE 346
Cdd:TIGR00435 141 VYFDVSKFKD-----YGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 347 CSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTAR 426
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 427 QLRLAFLMHSWKDTLDYSNNTMESA-IQYERFINEffLNVKDilrspTDITGQYEkWEAEEIELNKCFYDkktSVHGALC 505
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFSEELLEAAkNALERLYKA--LRVLD-----TSLAYSGN-QSLNKFPDEKEFEA---RFVEAMD 355
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 506 DNIDTRSALEEMRALVGQSNTYMA--ARRSAKLPPnrmlLQSIALYLTDMLKtfgaiegtDPIGF-PVGGNGQSADLEST 582
Cdd:TIGR00435 356 DDLNTANALAVLFELAKSINLTFVskADAALLIEH----LIFLESRLGLLLG--------LPSKPvQAGSNDDLGEIEAL 423
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 528485085 583 VMPylsvlsdfredvRKIAREKKVtelLQLCDQLRDDtLPELGVRLEDR 631
Cdd:TIGR00435 424 IEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDT 456
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
41-454 |
1.84e-138 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 409.45 E-value: 1.84e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 41 FVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARQNYLleqyrekkps 120
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGE---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 121 aaqilqdvltartPFKAklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvlleeakdllsdwldsq 200
Cdd:pfam01406 71 -------------SFRQ--------------------------------------------------------------- 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 201 fgsqvtensifslLPKYWEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYES-NGSVYFDTAKFdscpa 279
Cdd:pfam01406 75 -------------LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 280 HSYAKLVPEAVGDQKALQEGEGDlsisadrlSEKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESM 359
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 360 DIHGGGFDLRFPHHDNELAQSEAYFENDyWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKD 439
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*
gi 528485085 440 TLDYSnntmESAIQY 454
Cdd:pfam01406 288 PLDFS----EELLEQ 298
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
29-444 |
1.71e-111 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 336.47 E-value: 1.71e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 29 RLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYFkYDVFYCMNITDIDDKIIKRARQN 108
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 109 YLleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvllee 188
Cdd:cd00672 80 GL------------------------------------------------------------------------------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 189 akdllsDWLDsqfgsqvtensifslLPKYWEGEYHKDMEALNVLPPDVLTRVseyvpeivefvkkivdngygyesngsvy 268
Cdd:cd00672 82 ------SWKE---------------VADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 269 fdtakfdscpahsyaklvpeavgdqkalqegegdlsisadrlsekrsqndfalwkaskpgepswdspwgmgrpgWHIECS 348
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 349 AMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQL 428
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 528485085 429 RLAFLMHSWKDTLDYS 444
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
27-451 |
6.12e-88 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 287.60 E-value: 6.12e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 27 KLRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRAR 106
Cdd:PLN02946 59 ELHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKIIARAN 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 107 QnylleqyrekkpsaaqilqdvltartpfkakLAEttDPdkkqmlerldsavdaalgplqvavqskaaqdsiqkqaqvll 186
Cdd:PLN02946 138 E-------------------------------LGE--DP----------------------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 187 eeakdllsdwldsqfgsqvtensiFSLLPKYWEgEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYESNGS 266
Cdd:PLN02946 144 ------------------------ISLSRRYCE-EFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVDGD 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 267 VYFDTAKFDScpahsYAKLVPEAVGDQKAlqeGEgdlSISADrlSEKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIE 346
Cdd:PLN02946 199 VYFSVDKFPE-----YGKLSGRKLEDNRA---GE---RVAVD--SRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIE 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 347 CSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFEnDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTAR 426
Cdd:PLN02946 266 CSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACC-DSNISYWIHNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPL 344
|
410 420
....*....|....*....|....*
gi 528485085 427 QLRLAFLMHSWKDTLDYSNNTMESA 451
Cdd:PLN02946 345 ALRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
16-536 |
2.28e-60 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 216.12 E-value: 2.28e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 16 PWSPPEGTDiSKLR-------------LYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKN 82
Cdd:PRK14535 204 PWSVSTGTE-QKLSseqqrlihnpmttIYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRE 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 83 yFKYDVFYCMNITDIDDKIIKRARQNylleqyrekkpsaaqilqdvltartpfkaklAETTDPDKKQMLERLdsavdaal 162
Cdd:PRK14535 283 -CGYPLTYVRNITDIDDKIIARAAEN-------------------------------GETIGELTARFIQAM-------- 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 163 gplqvavqskaaqdsiqkqaqvlleeakdllsdwldsqfgsqvtensifsllpkywegeyHKDMEALNVLPPDVLTRVSE 242
Cdd:PRK14535 323 ------------------------------------------------------------HEDADALGVLRPDIEPKATE 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 243 YVPEIVEFVKKIVDNGYGY-ESNGSVYFDTAKFDScpahsYAKLVPEAVGDQKALQEGEGDlsisadrlSEKRSQNDFAL 321
Cdd:PRK14535 343 NIPQMIAMIETLIQNGKAYpAANGDVYYAVREFAA-----YGQLSGKSLDDLRAGERVEVD--------GFKRDPLDFVL 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 322 WKASKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQS---------EAYFENDY---- 388
Cdd:PRK14535 410 WKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQSvgatghtcgHHHAQTHHgqsi 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 389 --WVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKDTLDYSNNTMESAiqyERFINEFFLNVK 466
Cdd:PRK14535 490 asHVKYWLHNGFIRVDGEKMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA---KGALTRLYTTLK 566
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 467 DilrSPtditgqyekweAEEIELNKCFYDKKTSVHGALCDNIDTRSALEEMRALVGQSNTYMAARRSAKL 536
Cdd:PRK14535 567 N---TP-----------AAEFMLSENVNDYTRRFYAAMNDDFGTVEAVAVLFELAGEVNKTNDAQLAGCL 622
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
27-525 |
3.99e-60 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 210.93 E-value: 3.99e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 27 KLRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIddkiikrar 106
Cdd:PRK14536 2 ALRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITDV--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 107 qNYLleqyrekkpsaaqilqdvltartpfkaklaeTTDPDkkqmlerldsavdaalgplqvavqskAAQDSIQKQAQvll 186
Cdd:PRK14536 72 -GHL-------------------------------TDDAD--------------------------SGEDKMVKSAQ--- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 187 EEAKDLLSdwldsqfgsqvtensifslLPKYWEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYESNGS 266
Cdd:PRK14536 91 EHGKSVLE-------------------IAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCAGGN 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 267 VYFDTAKFDScpahsYAKLVPEAVGDqkaLQEGEgdlSISADrlSEKRSQNDFALWKASKPGEP---SWDSPWGMGRPGW 343
Cdd:PRK14536 152 VYFDIRTFPS-----YGSLASAAVED---LQAGA---RIEHD--TNKRNPHDFVLWFTRSKFENhalTWDSPWGRGYPGW 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 344 HIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAyFENDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAK- 422
Cdd:PRK14536 219 HIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEA-ATGKPWVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKg 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 423 HTARQLRLAFLMHSWKDTLDYSNNTMESAIQYERFINEFFLNVKDILRSPTDIT-GQYEKWEAEEIELNKCFYDKK--TS 499
Cdd:PRK14536 298 FQPLDYRFFLLGGHYRSQLAFSWEALKTAKAARRSLVRRVARVVDAARATTGSVrGTLAECAAERVAESRASESELllTD 377
|
490 500
....*....|....*....|....*.
gi 528485085 500 VHGALCDNIDTRSALEEMRALVGQSN 525
Cdd:PRK14536 378 FRAALEDDFSTPKALSELQKLVKDTS 403
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
28-453 |
1.37e-59 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 206.88 E-value: 1.37e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNslTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYfKYDVFYCMNITDIDDKiikrarq 107
Cdd:TIGR03447 18 LRLFD--TADGQVRPVEPGPEAGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHYVQNVTDVDDP------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 108 nylleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqMLERldsavdaalgplqvavqskAAQDSIqkqaqvlle 187
Cdd:TIGR03447 88 ------------------------------------------LFER-------------------AERDGV--------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 188 eakdllsDWLDsqFGSQVTEnsIFsllpkywegeyHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYE----S 263
Cdd:TIGR03447 98 -------DWRE--LGTSQID--LF-----------REDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYIvegpE 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 264 NGSVYFD---TAKFDSCPAHSYA---KLVPEAVGDqkalqegegdlsisADRLSeKRSQNDFALWKASKPGEPSWDSPWG 337
Cdd:TIGR03447 156 YPDVYFSidaTEQFGYESGYDRAtmlELFAERGGD--------------PDRPG-KRDPLDALLWRAAREGEPSWDSPFG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 338 MGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFENDYWVRYFLHTGHLTIAGCKMSKSLKNFITI- 416
Cdd:TIGR03447 221 RGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKMSKSLGNLVFVs 300
|
410 420 430
....*....|....*....|....*....|....*..
gi 528485085 417 KDALAKHTARQLRLAFLMHSWKDTLDYSNNTMESAIQ 453
Cdd:TIGR03447 301 KLRAAGVDPAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
46-453 |
6.49e-59 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 204.39 E-value: 6.49e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 46 GNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKNYfKYDVFYCMNITDIDDkiikrarqnylleqyrekkpsaaqil 125
Cdd:PRK12418 7 GGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDD-------------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 126 qdvltartpfkaklaettdPdkkqMLERldsavdaalgplqvavqskAAQDSIqkqaqvlleeakdllsDWLDsqFGSQV 205
Cdd:PRK12418 60 -------------------P----LLER-------------------AARDGV----------------DWRD--LAERE 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 206 TEnsIFsllpkywegeyHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDNGYGYE----SNGSVYFDTakfDSCPAHS 281
Cdd:PRK12418 80 IA--LF-----------REDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYVvddeEYPDVYFSV---DATPQFG 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 282 Y---------AKLVPEAVGDqkalqegegdlsisADRLSeKRSQNDFALWKASKPGEPSWDSPWGMGRPGWHIECSAMAG 352
Cdd:PRK12418 144 YesgydratmLELFAERGGD--------------PDRPG-KRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIAL 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 353 SILGESMDIHGGGFDLRFPHHDNELAQSEAYFENDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALA-KHTARQLRLA 431
Cdd:PRK12418 209 NRLGSGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVFVSRLRAaGVDPAAIRLA 288
|
410 420
....*....|....*....|..
gi 528485085 432 FLMHSWKDTLDYSNNTMESAIQ 453
Cdd:PRK12418 289 LLAGHYRADREWTDAVLAEAEA 310
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
28-495 |
1.28e-45 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 170.03 E-value: 1.28e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 28 LRLYNslTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDI---------- 97
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDIghltgdfddg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 98 DDKIIKRARQNylleqyrekkpsaaqilqdvltartpfkaklaettdpdkkqmlerldsavdaalgplqvavqskaaqds 177
Cdd:PRK14534 80 EDKVVKAARER--------------------------------------------------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 178 iqkqaqvlleeakdllsdwldsqfGSQVTENSifsllpKYWEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDN 257
Cdd:PRK14534 91 ------------------------GLTVYEIS------RFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEEN 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 258 GYGYESNGSVYFDTAKFDScpahsYAKLVPEAVGDQKALQEGEGDLSISadrlseKRSQNDFALWKAS---KPGEPSWDS 334
Cdd:PRK14534 141 GFTYFVNGNVYFDTSCFKS-----YGQMAGINLNDFKDMSVSRVEIDKS------KRNKSDFVLWFTNskfKDQEMKWDS 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 335 PWGMGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFeNDYWVRYFLHTGHLTIAGCKMSKSLKNFI 414
Cdd:PRK14534 210 PWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAECYL-NKKWCDMFVHGEFLIMEYEKMSKSNNNFI 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 415 TIKDALAKH-TARQLRLAFLMHSWKDTLDYS-NNTMESAIQYERFINE---FFLNVkdilrSPTDITGQYEKWEAEEIEL 489
Cdd:PRK14534 289 TIKDLEDQGfSPLDFRYFCLTAHYRTQLKFTfNNLKACKIARENMLNKltyFYSSL-----DQFDLNLLNKDLENIEFSL 363
|
....*.
gi 528485085 490 NKCFYD 495
Cdd:PRK14534 364 EKEYYD 369
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
382-531 |
1.24e-08 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 58.73 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 382 AYFENDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLaFLMHS---WKDtLDYSNNTMESAI-QYERF 457
Cdd:PRK12300 554 AIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRL-YLTSSaelLQD-ADWREKEVESVRrQLERF 631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 458 InEFFLNVKDIlrSPTDITGQYEKWeaeeiELNKcFYDKKTSVHGALcDNIDTRSALEEM-----------RALVGQSNT 526
Cdd:PRK12300 632 Y-ELAKELIEI--GGEEELRFIDKW-----LLSR-LNRIIKETTEAM-ESFQTRDAVQEAfyellndlrwyLRRVGEANN 701
|
....*
gi 528485085 527 YMAAR 531
Cdd:PRK12300 702 KVLRE 706
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
54-108 |
8.64e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 45.93 E-value: 8.64e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 528485085 54 CGPTVYDASHMGHARSYISFDILRRILKnYFKYDVFYCMNITDIDDKIIKRARQN 108
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYR-KLGYKVRCIALIDDAGGLIGDPANKK 57
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
366-461 |
8.82e-06 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 49.30 E-value: 8.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485085 366 FDLRFPHHD---NELAQS----EAYFENDYWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRlaFLMHSWK 438
Cdd:PLN02959 672 FDLRVSGKDliqNHLTFAiynhTAIWAEEHWPRGFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATR--FALADAG 749
|
90 100
....*....|....*....|....*.
gi 528485085 439 DTLDYSN---NTMESAIQyeRFINEF 461
Cdd:PLN02959 750 DGVDDANfvfETANAAIL--RLTKEI 773
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
342-410 |
4.32e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 41.31 E-value: 4.32e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528485085 342 GWHIECSAMAGSILGESMDIHGGGFDLRFpHHDNELAQSEAYfendYW--VRYFLHTGHLTIA-GCKMSKSL 410
Cdd:cd00802 77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKA----GGpaRPFGLTFGRVMGAdGTKMSKSK 143
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
396-436 |
9.37e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 42.28 E-value: 9.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 528485085 396 TGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHS 436
Cdd:pfam09334 315 HGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNR 355
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
390-436 |
9.57e-04 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 42.13 E-value: 9.57e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 528485085 390 VRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHS 436
Cdd:cd00814 265 PTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| |
