Rrp1b ribosomal RNA processing 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rrp1bprovided by MGI
Official Full Name: ribosomal RNA processing 1Bprovided by MGI
Primary source: MGI:MGI:1919712
See related: Ensembl:ENSMUSG00000058392 AllianceGenome:MGI:1919712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa0179; mKIAA0179; D030064A17; 2600005C20Rik
Summary: Predicted to enable transcription coactivator activity. Involved in negative regulation of GTPase activity and regulation of RNA splicing. Located in euchromatin; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and sternum. Orthologous to human RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.4), limb E14.5 (RPKM 6.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.34 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32255087..32281839)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32036162..32062865)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Title: RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.
RRP1B, a tumor progression and metastasis susceptibility candidate gene, is potentially a dynamic modulator of transcription and chromatin structure
Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

2600005C20Rik (e-PCR), detects polymorphism
- UniSTS:234009

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH126888 (e-PCR)
- UniSTS:209290

Rrp1b (e-PCR), detects polymorphism
- UniSTS:259022

Rrp1b (e-PCR), detects polymorphism
- UniSTS:259571

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in granular component	ISO Inferred from Sequence Orthology more info
located_in granular component	ISS Inferred from Sequence or Structural Similarity more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of preribosome, small subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal RNA processing protein 1 homolog B

Names: RRP1-like protein B; ribosomal RNA processing 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163734.1 → NP_001157206.1 ribosomal RNA processing protein 1 homolog B isoform 2

See identical proteins and their annotated locations for NP_001157206.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

CT033797

UniProtKB/TrEMBL

Q6ZQH4

Related

ENSMUST00000147076.8

Conserved Domains (2) summary

pfam06070
Location:301 → 617

Herpes_UL32; Herpesvirus large structural phosphoprotein UL32

pfam05997
Location:1 → 117

Nop52; Nucleolar protein,Nop52
NM_028244.2 → NP_082520.2 ribosomal RNA processing protein 1 homolog B isoform 1

See identical proteins and their annotated locations for NP_082520.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CT033797

Consensus CDS

CCDS28613.1

UniProtKB/Swiss-Prot

B0V2W7, Q91YK2

UniProtKB/TrEMBL

Q6ZQH4

Related

ENSMUSP00000080085.7, ENSMUST00000081339.13

Conserved Domains (1) summary

pfam05997
Location:11 → 218

Nop52; Nucleolar protein,Nop52

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32255087..32281839

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160793.1 → XP_036016686.1 ribosomal RNA processing protein 1 homolog B isoform X2

UniProtKB/TrEMBL

Q6ZQH4

Conserved Domains (1) summary

pfam05997
Location:20 → 145

Nop52; Nucleolar protein,Nop52
XM_006524971.3 → XP_006525034.1 ribosomal RNA processing protein 1 homolog B isoform X1

UniProtKB/TrEMBL

Q6ZQH4

Conserved Domains (2) summary

pfam06070
Location:332 → 648

Herpes_UL32; Herpesvirus large structural phosphoprotein UL32

pfam05997
Location:2 → 148

Nop52; Nucleolar protein,Nop52
XM_006524972.3 → XP_006525035.1 ribosomal RNA processing protein 1 homolog B isoform X3

See identical proteins and their annotated locations for XP_006525035.1

UniProtKB/TrEMBL

Q6ZQH4

Conserved Domains (2) summary

pfam06070
Location:301 → 617

Herpes_UL32; Herpesvirus large structural phosphoprotein UL32

pfam05997
Location:1 → 117

Nop52; Nucleolar protein,Nop52