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    Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 72508, updated on 24-Dec-2024

    Summary

    Official Symbol
    Rps6kb1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1270849
    See related
    Ensembl:ENSMUSG00000020516 AllianceGenome:MGI:1270849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
    Summary
    Enables protein kinase activity. Involved in several processes, including cellular response to type II interferon; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of signal transduction. Located in mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early conceptus; leg muscle; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Rps6kb1 in Genome Data Viewer
    Location:
    11 C; 11 51.82 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5258 Neighboring gene predicted gene, 26439 Neighboring gene STARR-positive B cell enhancer ABC_E5259 Neighboring gene STARR-positive B cell enhancer ABC_E3003 Neighboring gene STARR-seq mESC enhancer starr_30268 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene STARR-seq mESC enhancer starr_30269 Neighboring gene STARR-seq mESC enhancer starr_30270 Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene predicted gene 9975

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • 4732464A07Rik

    Gene Ontology Provided by MGI

    Items 1 - 25 of 40
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables peptide binding  
    enables peptide binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein phosphatase 2A binding  
    enables protein phosphatase 2A binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity PubMed 
    enables protein serine/threonine/tyrosine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 40
    Items 1 - 25 of 66
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in TOR signaling  
    involved_in TOR signaling  
    involved_in TORC1 signaling  
    acts_upstream_of_or_within TORC1 signaling PubMed 
    involved_in apoptotic process  
    acts_upstream_of_or_within behavioral fear response PubMed 
    involved_in cell migration  
    acts_upstream_of_or_within cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to insulin stimulus  
    acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
    involved_in cellular response to nutrient  
    involved_in cellular response to nutrient  
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in cellular response to type II interferon PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of_or_within germ cell development PubMed 
    involved_in long-chain fatty acid import into cell PubMed 
    involved_in long-term memory  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in negative regulation of TORC2 signaling PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of skeletal muscle tissue growth  
    involved_in positive regulation of skeletal muscle tissue growth  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of translation  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of translational initiation  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in regulation of D-glucose import  
    involved_in regulation of D-glucose import  
    involved_in response to L-leucine  
    involved_in response to electrical stimulus involved in regulation of muscle adaptation  
    involved_in response to ethanol  
    involved_in response to glucagon  
    involved_in response to glucose  
    involved_in response to insulin  
    involved_in response to lipopolysaccharide  
    involved_in response to mechanical stimulus  
    involved_in response to nutrient levels  
    involved_in response to testosterone  
    involved_in response to toxic substance  
    involved_in response to tumor necrosis factor  
    involved_in response to tumor necrosis factor  
    involved_in response to xenobiotic stimulus  
    involved_in skeletal muscle atrophy  
    involved_in skeletal muscle contraction  
    Items 1 - 25 of 66
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cell surface  
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in neuron projection  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in postsynapse  
    is_active_in postsynapse  
    is_active_in synapse  

    General protein information

    Preferred Names
    ribosomal protein S6 kinase beta-1
    Names
    70 kDa ribosomal protein S6 kinase 1
    p70 S6 kinase alpha
    p70 ribosomal S6 kinase alpha
    ribosomal protein S6 kinase I
    ribosomal protein S6 kinase, 70kD, polypeptide 1
    NP_001107806.1
    NP_001350091.1
    NP_082535.1
    XP_006534378.1
    XP_011247577.1
    XP_011247578.1
    XP_036012907.1
    XP_036012908.1
    XP_036012909.1
    XP_036012910.1
    XP_036012911.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114334.2NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001107806.1

      Status: VALIDATED

      Source sequence(s)
      AK032724, AK135716, AL604063
      Consensus CDS
      CCDS48875.1
      UniProtKB/Swiss-Prot
      Q5SWG1, Q8BSK8, Q8CHX0
      UniProtKB/TrEMBL
      Q3UXD8
      Related
      ENSMUSP00000119715.2, ENSMUST00000154617.8
      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    2. NM_001363162.1NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604063
      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:41363
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    3. NM_028259.4NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

      See identical proteins and their annotated locations for NP_082535.1

      Status: VALIDATED

      Source sequence(s)
      AL604063
      Consensus CDS
      CCDS25201.1
      UniProtKB/TrEMBL
      Q8C3J7
      Related
      ENSMUSP00000053188.3, ENSMUST00000058286.9
      Conserved Domains (1) summary
      cl21453
      Location:94195
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86389695..86435711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157018.1XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:1157
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036157014.1XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036157016.1XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036157017.1XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036157015.1XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011249275.4XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    7. XM_006534315.5XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:48336
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    8. XM_011249276.4XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

      Conserved Domains (1) summary
      cd05584
      Location:94409
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    RNA

    1. XR_004937046.1 RNA Sequence

    2. XR_004937048.1 RNA Sequence

    3. XR_004937047.1 RNA Sequence

    4. XR_001780060.3 RNA Sequence

    5. XR_003949511.2 RNA Sequence

    6. XR_003949513.1 RNA Sequence

    7. XR_879743.4 RNA Sequence

    8. XR_004937043.1 RNA Sequence

    9. XR_004937042.1 RNA Sequence

    10. XR_004937044.1 RNA Sequence

    11. XR_004937045.1 RNA Sequence

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