MAPK8 mitogen-activated protein kinase 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK8provided by HGNC
Official Full Name: mitogen-activated protein kinase 8provided by HGNC
Primary source: HGNC:HGNC:6881
See related: Ensembl:ENSG00000107643 MIM:601158; AllianceGenome:HGNC:6881
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Expression: Ubiquitous expression in brain (RPKM 9.4), thyroid (RPKM 7.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q11.22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (48306677..48439360)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (49155699..49288442)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (49514720..49647403)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
Title: Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy.
Title: DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy.
Leukocyte Ig-like receptor A3 facilitates inflammation, migration and invasion of synovial tissue-derived fibroblasts via ERK/JNK activation.
Title: Leukocyte Ig-like receptor A3 facilitates inflammation, migration and invasion of synovial tissue-derived fibroblasts via ERK/JNK activation.
Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.
Title: Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.
JNK promotes the progression of castration-resistant prostate cancer.
Title: JNK promotes the progression of castration-resistant prostate cancer.
HPV16 E7 protein antagonizes TNF-alpha-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.
Title: HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.
H3K27 acetylation activated-CD109 evokes 5-fluorouracil resistance in gastric cancer via the JNK/MAPK signaling pathway.
Title: H3K27 acetylation activated-CD109 evokes 5-fluorouracil resistance in gastric cancer via the JNK/MAPK signaling pathway.
MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
Title: MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.
Title: JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.
N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.
Title: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.

Submit: New GeneRIF Correction See all GeneRIFs (659)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env gp120 upregulates MAPK8 (JNK) in SVGA cells, human fetal astrocytes, and the prefrontal cortex of gp120 transgenic mice	PubMed
	env	HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells	PubMed
	env	Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK	PubMed
	env	NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response	PubMed
	env	HIV-1 Env-pseudotyped virus-infected MDM cells induce cellular apoptosis through reactive oxygen species (ROS) generation and JNK phosphorylation	PubMed
	env	CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK	PubMed
	env	The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120	PubMed
	env	HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells	PubMed
	env	Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB	PubMed
	env	HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes	PubMed
Envelope surface glycoprotein gp160, precursor	env	The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells	PubMed
	env	Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin	PubMed
Nef	nef	HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1	PubMed
	nef	HIV-1 Nef inhibits ASK1-induced phosphorylation of p54/p46 JNK in cells. Nef mutant (152DEVGEANN/AAAAAAAA159) abolishes its inhibitory activity	PubMed
	nef	HIV-1 Nef activates c-jun nuclear kinase (JNK) in human glial cells and the resulting activation promotes cell proliferation	PubMed
	nef	The interaction between HIV-1 Nef and Vav leads to the activation of c-Jun N-terminal kinase (JNK)	PubMed
	nef	Using genetic and immunohistochemical studies in Drosophila transgenic lines, wild-type HIV-1 Nef demonstrates induction of JNK activation and apoptotic activities	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of MAPK8 (JNK) in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes	PubMed
	tat	Pretreatment of microglia with HIV-1 Tat followed by treatment with CX3CL1 results in inhibition of CX3CL1-mediated activation of ERK1/2 and JNK MAPKs compared to cells not treated with Tat	PubMed
	tat	HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes	PubMed
	tat	Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression	PubMed
	tat	Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP	PubMed
	tat	HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck	PubMed
	tat	Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells	PubMed
	tat	Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38	PubMed
	tat	HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation	PubMed
	tat	Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat	PubMed
	tat	HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1)	PubMed
	tat	Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways	PubMed
	tat	HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha	PubMed
	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT	PubMed
	tat	Activation of JNK by HIV-1 Tat is mediated by TRAF4	PubMed
Vpr	vpr	HIV-1 Vpr-mediated regulation of IL6 involves MAPK8 (JnK-MAPK8) in astrocytes	PubMed
	vpr	Vpr-mediated CXCL8 (IL8) secretion from astrocytes involves MAPK8 (Jnk-MAPK)	PubMed
	vpr	Vpr-mediated CXCL8 (IL8) mRNA expression involves MAPK8 (Jnk-MAPK) in astrocytes	PubMed
	vpr	Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages.	PubMed
integrase	gag-pol	Cellular JNK1 phosphorylates HIV-1 IN on Ser57, leading to efficient HIV-1 infection and integration in primary human T lymphocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G17482 (e-PCR)
- UniSTS:52538

RH69616 (e-PCR)
- UniSTS:47949

STS-L26318 (e-PCR)
- UniSTS:6223

NoName (e-PCR)
- UniSTS:490336

A004M36 (e-PCR)
- UniSTS:62067

D10S2185 (e-PCR)
- UniSTS:27764

G17487 (e-PCR)
- UniSTS:61314

HSC1IF052 (e-PCR)
- UniSTS:25988

STS-T94087 (e-PCR)
- UniSTS:42388

MARC_12374-12375:997362452:1 (e-PCR)
- UniSTS:267421

MARC_13424-13425:1002294866:1 (e-PCR)
- UniSTS:267492

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables JUN kinase activity	TAS Traceable Author Statement more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	TAS Traceable Author Statement more info
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within JUN phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in JUN phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	TAS Traceable Author Statement more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	TAS Traceable Author Statement more info
involved_in positive regulation of cell killing	TAS Traceable Author Statement more info
involved_in positive regulation of cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of protein localization to mitochondrion	TAS Traceable Author Statement more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macroautophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in basal dendrite	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 8

Names: JUN N-terminal kinase; MAP kinase 8; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c

NP_001265476.1

EC 2.7.11.24

NP_001265477.1

EC 2.7.11.24

NP_001310231.1

EC 2.7.11.24

NP_001310249.1

EC 2.7.11.24

NP_001310250.1

EC 2.7.11.24

NP_001310251.1

EC 2.7.11.24

NP_001310252.1

EC 2.7.11.24

NP_001310253.1

EC 2.7.11.24

NP_001310254.1

EC 2.7.11.24

NP_001310255.1

EC 2.7.11.24

NP_001310256.1

EC 2.7.11.24

NP_001310257.1

EC 2.7.11.24

NP_001310258.1

EC 2.7.11.24

NP_001310259.1

EC 2.7.11.24

NP_001310260.1

EC 2.7.11.24

NP_620634.1

EC 2.7.11.24

NP_620637.1

EC 2.7.11.24

XP_024303847.1

EC 2.7.11.24

XP_024303848.1

EC 2.7.11.24

XP_047281436.1

EC 2.7.11.24

XP_047281437.1

EC 2.7.11.24

XP_047281438.1

EC 2.7.11.24

XP_047281440.1

EC 2.7.11.24

XP_054222274.1

EC 2.7.11.24

XP_054222275.1

EC 2.7.11.24

XP_054222276.1

EC 2.7.11.24

XP_054222277.1

EC 2.7.11.24

XP_054222278.1

EC 2.7.11.24

XP_054222279.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029053.2 RefSeqGene

Range

5039..137722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001278547.2 → NP_001265476.1 mitogen-activated protein kinase 8 isoform beta2

See identical proteins and their annotated locations for NP_001265476.1

Status: REVIEWED

Description

Transcript Variant: This variant (JNK1-b2) encodes the longer of the two JNK1 beta isoforms (JNK1 beta2). The JNK1-b2 variant differs from the JNK1-a2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta2 isoform is the same length as JNK1 alpha2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b2, 8, 9, and 16 all encode isoform beta2.

Source sequence(s)

AA808177, AC016397, AK292523, DA159335

Consensus CDS

CCDS7223.1

UniProtKB/TrEMBL

A0A286YES9, A1L4K2

Related

ENSP00000378974.4, ENST00000395611.7

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001278548.2 → NP_001265477.1 mitogen-activated protein kinase 8 isoform 5

See identical proteins and their annotated locations for NP_001265477.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame segment and uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (5) with a different C-terminus compared to isoform JNK1 beta2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS60527.1

UniProtKB/TrEMBL

B5BUB8

Related

ENSP00000353483.4, ENST00000360332.7

Conserved Domains (1) summary

cl21453
Location:25 → 284

PKc_like; Protein Kinases, catalytic domain
NM_001323302.2 → NP_001310231.1 mitogen-activated protein kinase 8 isoform alpha1

Status: REVIEWED

Description

Transcript Variant: This variant (JNK1-a1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-a2, resulting in a frameshift and a shorter isoform (JNK1 alpha1) with a different C-terminus, compared to isoform JNK1 alpha2. The JNK1-a1 variant differs from the JNK1-b1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha1 isoform is the same length as JNK1 beta1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a1, 10, 12, and 13 all encode isoform alpha1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7225.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323320.2 → NP_001310249.1 mitogen-activated protein kinase 8 isoform 6

Status: REVIEWED

Source sequence(s)

AC016397, AC074325

UniProtKB/TrEMBL

A0A286YES9
NM_001323321.2 → NP_001310250.1 mitogen-activated protein kinase 8 isoform beta1

Status: REVIEWED

Description

Transcript Variant: This variant (7), along with variants JNK1-b1 and 11, encodes isoform beta1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7226.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323322.2 → NP_001310251.1 mitogen-activated protein kinase 8 isoform beta2

Status: REVIEWED

Description

Transcript Variant: This variant (8), along with variants JNK1-b2, 9, and 16, encodes isoform beta2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7223.1

UniProtKB/TrEMBL

A0A286YES9, A1L4K2

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323323.2 → NP_001310252.1 mitogen-activated protein kinase 8 isoform beta2

Status: REVIEWED

Description

Transcript Variant: This variant (9), along with variants JNK1-b2, 8, and 16, encodes isoform beta2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7223.1

UniProtKB/TrEMBL

A0A286YES9, A1L4K2

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323324.2 → NP_001310253.1 mitogen-activated protein kinase 8 isoform alpha1

Status: REVIEWED

Description

Transcript Variant: This variant (10), along with variants JNK1-a1, 12, and 13, encodes isoform alpha1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7225.1

UniProtKB/TrEMBL

B5BUB8

Related

ENSP00000363297.3, ENST00000374182.7

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323325.2 → NP_001310254.1 mitogen-activated protein kinase 8 isoform beta1

Status: REVIEWED

Description

Transcript Variant: This variant (11), along with variants JNK1-b1 and 7, encodes isoform beta1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7226.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323326.2 → NP_001310255.1 mitogen-activated protein kinase 8 isoform alpha1

Status: REVIEWED

Description

Transcript Variant: This variant (12), along with variants JNK1-a1, 10, and 13, encodes isoform alpha1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7225.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323327.2 → NP_001310256.1 mitogen-activated protein kinase 8 isoform alpha1

Status: REVIEWED

Description

Transcript Variant: This variant (13), along with variants JNK1-a1, 10, and 12, encodes isoform alpha1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7225.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323328.2 → NP_001310257.1 mitogen-activated protein kinase 8 isoform alpha2

Status: REVIEWED

Description

Transcript Variant: This variant (14), along with variants JNK1-a2, 15, and 17, encodes isoform alpha2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7224.1

UniProtKB/Swiss-Prot

B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2

UniProtKB/TrEMBL

A0A286YEN5

Conserved Domains (2) summary

smart00220
Location:26 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323329.2 → NP_001310258.1 mitogen-activated protein kinase 8 isoform alpha2

Status: REVIEWED

Description

Transcript Variant: This variant (15), along with variants JNK1-a2, 14, and 17, encodes isoform alpha2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7224.1

UniProtKB/Swiss-Prot

B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2

UniProtKB/TrEMBL

A0A286YEN5

Related

ENSP00000363304.1, ENST00000374189.6

Conserved Domains (2) summary

smart00220
Location:26 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323330.2 → NP_001310259.1 mitogen-activated protein kinase 8 isoform beta2

Status: REVIEWED

Description

Transcript Variant: This variant (16), along with variants JNK1-b2, 8, and 9, encodes isoform beta2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7223.1

UniProtKB/TrEMBL

A0A286YES9, A1L4K2

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001323331.2 → NP_001310260.1 mitogen-activated protein kinase 8 isoform alpha2

Status: REVIEWED

Description

Transcript Variant: This variant (17), along with variants JNK1-a2, 14, and 15, encodes isoform alpha2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7224.1

UniProtKB/Swiss-Prot

B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2

UniProtKB/TrEMBL

A0A286YEN5

Conserved Domains (2) summary

smart00220
Location:26 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_139046.4 → NP_620634.1 mitogen-activated protein kinase 8 isoform beta1

See identical proteins and their annotated locations for NP_620634.1

Status: REVIEWED

Description

Transcript Variant: This variant (JNK1-b1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (JNK1 beta1) with a different C-terminus, compared to isoform JNK1 beta2. The JNK1-b1 variant differs from the JNK1-a1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta1 isoform is the same length as JNK1 alpha1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b1, 7, and 11 all encode isoform beta1.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7226.1

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_139049.4 → NP_620637.1 mitogen-activated protein kinase 8 isoform alpha2

See identical proteins and their annotated locations for NP_620637.1

Status: REVIEWED

Description

Transcript Variant: This variant (JNK1-a2) encodes the longer of the two JNK1 alpha isoforms (JNK1 alpha2). The JNK1-a2 variant differs from the JNK1-b2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha2 isoform is the same length as JNK1 beta2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a2, 14, 15 and 17 all encode isoform alpha2.

Source sequence(s)

AC016397, AC074325

Consensus CDS

CCDS7224.1

UniProtKB/Swiss-Prot

B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2

UniProtKB/TrEMBL

A0A286YEN5

Conserved Domains (2) summary

smart00220
Location:26 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

NR_136583.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC016397, AC074325
NR_136584.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC016397, AC074325
NR_136585.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC016397, AC074325

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

48306677..48439360

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425482.1 → XP_047281438.1 mitogen-activated protein kinase 8 isoform X2

Related

ENSP00000363294.3, ENST00000374179.8
XM_047425480.1 → XP_047281436.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A1L4K2
XM_047425484.1 → XP_047281440.1 mitogen-activated protein kinase 8 isoform X2
XM_024448079.2 → XP_024303847.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A0A286YES9, A1L4K2

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_024448080.2 → XP_024303848.1 mitogen-activated protein kinase 8 isoform X2

UniProtKB/TrEMBL

B5BUB8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_047425481.1 → XP_047281437.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A1L4K2

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

49155699..49288442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054366303.1 → XP_054222278.1 mitogen-activated protein kinase 8 isoform X2
XM_054366299.1 → XP_054222274.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A1L4K2
XM_054366304.1 → XP_054222279.1 mitogen-activated protein kinase 8 isoform X2
XM_054366300.1 → XP_054222275.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A1L4K2
XM_054366302.1 → XP_054222277.1 mitogen-activated protein kinase 8 isoform X2
XM_054366301.1 → XP_054222276.1 mitogen-activated protein kinase 8 isoform X1

UniProtKB/TrEMBL

A1L4K2