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    ccn4b cellular communication network factor 4b [ Danio rerio (zebrafish) ]

    Gene ID: 792714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccn4bprovided by ZNC
    Official Full Name
    cellular communication network factor 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080220-16
    See related
    Ensembl:ENSDARG00000076685 AllianceGenome:ZFIN:ZDB-GENE-080220-16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wisp1b; zgc:172276
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; positive regulation of cell differentiation; and signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in thyroid follicle. Orthologous to human CCN4 (cellular communication network factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ccn4b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31518783..31525232, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31560520..31567354, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4A3b Neighboring gene N-myc downstream regulated 1b Neighboring gene src-like-adapter Neighboring gene thyroglobulin Neighboring gene PHD finger protein 20 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Temporal and spatial expression of CCN genes in zebrafish. Fernando CA, et al. Dev Dyn, 2010 Jun. PMID 20503371, Free PMC Article
    2. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Khayrullin A, et al. Biochem Biophys Res Commun, 2016 Oct 21. PMID 27671199
    3. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cellular communication network factor 4b
    Names
    WNT1 inducible signaling pathway protein 1b
    zWISP1-c16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113628.1 → NP_001107100.1  cellular communication network factor 4b precursor

      See identical proteins and their annotated locations for NP_001107100.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154630
      UniProtKB/TrEMBL
      A8WG98
      Related
      ENSDARP00000099684.3, ENSDART00000109996.4
      Conserved Domains (4) summary
      smart00209
      Location:208 → 249
      TSP1; Thrombospondin type 1 repeats
      smart00214
      Location:115 → 174
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:41 → 93
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:272 → 335
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      31518783..31525232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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