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Conserved domains on  [gi|165972425|ref|NP_001107100|]
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cellular communication network factor 4b precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 205-248 3.89e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 3.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 165972425  205 CIAQTTPWSPCSKTCGRGISLRISNENAGCVMEKESRLCNLRPC 248
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-93 2.68e-08

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 49.63  E-value: 2.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   41 CKWPC---KCPKSALVCPHGVslLMDGCDCCKACAKQAGETCNERD-ICDyhKGLYC 93
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
115-174 5.22e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.27  E-value: 5.22e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 165972425   115 CEYNGVIYRNGQSFQPNCKYRCLCVNGA-IGCVPLctdSLPPRVWCQSPKRVKIPGQCCEK 174
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCPR 58
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 272-335 4.14e-03

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 35.84  E-value: 4.14e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   272 QNFTISGCvSKKPYWPKYC-GVCTDE------------RCCIPYKSKTIEVEFECPDGALLTWKYMWINACFCNLSC 335
Cdd:smart00041   6 QTITYNGC-TSVTVKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 205-248 3.89e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 3.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 165972425  205 CIAQTTPWSPCSKTCGRGISLRISNENAGCVMEKESRLCNLRPC 248
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-93 2.68e-08

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 49.63  E-value: 2.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   41 CKWPC---KCPKSALVCPHGVslLMDGCDCCKACAKQAGETCNERD-ICDyhKGLYC 93
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
115-174 5.22e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.27  E-value: 5.22e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 165972425   115 CEYNGVIYRNGQSFQPNCKYRCLCVNGA-IGCVPLctdSLPPRVWCQSPKRVKIPGQCCEK 174
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 115-173 4.60e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 4.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 165972425  115 CEYNGVIYRNGQSFQPNCKYRCLCVNGAIGCVPLCTDSLPprvwCQSPKRVKIPGQCCE 173
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLD----CPNPRLEIPPGECCP 55
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 44-101 1.10e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 40.14  E-value: 1.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 165972425    44 PCKCPKSALVCPHGVSLlmDGCDCCKACAKQAGETCN-ERDICdyHKGLYCDYSADKPR 101
Cdd:smart00121   8 PARCPPCPPGCAELVRL--DGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEER 62
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 208-249 2.29e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 165972425   208 QTTPWSPCSKTCGRGISLRI--------SNENAGCVME-KESRLCNLRPCE 249
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTGEdVETRACNEQPCP 53
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 272-335 4.14e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 35.84  E-value: 4.14e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   272 QNFTISGCvSKKPYWPKYC-GVCTDE------------RCCIPYKSKTIEVEFECPDGALLTWKYMWINACFCNLSC 335
Cdd:smart00041   6 QTITYNGC-TSVTVKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 205-248 3.89e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 3.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 165972425  205 CIAQTTPWSPCSKTCGRGISLRISNENAGCVMEKESRLCNLRPC 248
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-93 2.68e-08

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 49.63  E-value: 2.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   41 CKWPC---KCPKSALVCPHGVslLMDGCDCCKACAKQAGETCNERD-ICDyhKGLYC 93
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
115-174 5.22e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.27  E-value: 5.22e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 165972425   115 CEYNGVIYRNGQSFQPNCKYRCLCVNGA-IGCVPLctdSLPPRVWCQSPKRVKIPGQCCEK 174
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 115-173 4.60e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 4.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 165972425  115 CEYNGVIYRNGQSFQPNCKYRCLCVNGAIGCVPLCTDSLPprvwCQSPKRVKIPGQCCE 173
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLD----CPNPRLEIPPGECCP 55
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 44-101 1.10e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 40.14  E-value: 1.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 165972425    44 PCKCPKSALVCPHGVSLlmDGCDCCKACAKQAGETCN-ERDICdyHKGLYCDYSADKPR 101
Cdd:smart00121   8 PARCPPCPPGCAELVRL--DGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEER 62
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 210-248 2.71e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.41  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 165972425  210 TPWSPCSKTCGRGISLRI-------SNENAGCVMEKESRLCNLRPC 248
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 208-248 1.18e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 1.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 165972425  208 QTTPWSPCSKTCGRGISLR----------ISNENAGCVMEK---ESRLCNLRPC 248
Cdd:pfam19030   2 VAGPWGECSVTCGGGVQTRlvqcvqkgggSIVPDSECSAQKkppETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 208-249 2.29e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 165972425   208 QTTPWSPCSKTCGRGISLRI--------SNENAGCVME-KESRLCNLRPCE 249
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTGEdVETRACNEQPCP 53
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 272-335 4.14e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 35.84  E-value: 4.14e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 165972425   272 QNFTISGCvSKKPYWPKYC-GVCTDE------------RCCIPYKSKTIEVEFECPDGALLTWKYMWINACFCNLSC 335
Cdd:smart00041   6 QTITYNGC-TSVTVKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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