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    dlg3 discs, large homolog 3 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 564081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dlg3provided by ZNC
    Official Full Name
    discs, large homolog 3 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-93
    See related
    Ensembl:ENSDARG00000076796 AllianceGenome:ZFIN:ZDB-GENE-050208-93
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa66c08; fa66e02; fd02c12; fu95c12; im:7138640; wu:fa66c08; wu:fa66e02; wu:fd02c12; wu:fu95c12; si:ch211-276g21.1
    Summary
    Predicted to enable ionotropic glutamate receptor binding activity and protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to synapse; and receptor clustering. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including basolateral plasma membrane; neuromuscular junction; and postsynaptic density membrane. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dlg3 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33068737..33218105, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32729953..32877822, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 4 Neighboring gene kinase insert domain receptor like Neighboring gene testis expressed 11 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene PDZ domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. König C, et al. Mech Dev, 1999 Aug. PMID 10446262
    2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162970

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disks large homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      33068737..33218105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481213.2 → XP_021336888.1  disks large homolog 3 isoform X17

      UniProtKB/TrEMBL
      A0A2R8PXW1, A5PKT0, F6NMH9
      Related
      ENSDARP00000069206.4, ENSDART00000074720.7
      Conserved Domains (2) summary
      cd12029
      Location:19 → 85
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase

    2. XM_068213371.1 → XP_068069472.1  disks large homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1J7

    3. XM_021481211.2 → XP_021336886.1  disks large homolog 3 isoform X16

      UniProtKB/TrEMBL
      A0A8M3AS60
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00228
      Location:383 → 467
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:132 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:640 → 818
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:312 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    4. XM_068213376.1 → XP_068069477.1  disks large homolog 3 isoform X8

      UniProtKB/TrEMBL
      A0A8M9QBK2

    5. XM_021481210.2 → XP_021336885.1  disks large homolog 3 isoform X15

      UniProtKB/TrEMBL
      A0A8M9QPI1
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:658 → 836
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    6. XM_021481209.2 → XP_021336884.1  disks large homolog 3 isoform X14

      UniProtKB/TrEMBL
      A0A8M9QGS9
      Related
      ENSDARP00000073316.6, ENSDART00000078856.7
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:686 → 864
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    7. XM_021481208.2 → XP_021336883.1  disks large homolog 3 isoform X13

      UniProtKB/TrEMBL
      A0A8M9Q5B2
      Conserved Domains (5) summary
      cd12029
      Location:520 → 584
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:694 → 872
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    8. XM_021481198.2 → XP_021336873.1  disks large homolog 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QBJ7
      Conserved Domains (6) summary
      cd12029
      Location:569 → 633
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00228
      Location:450 → 534
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:150 → 234
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:743 → 921
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    9. XM_068213380.1 → XP_068069481.1  disks large homolog 3 isoform X12

      UniProtKB/TrEMBL
      A0A8M9PZT0

    10. XM_068213379.1 → XP_068069480.1  disks large homolog 3 isoform X11

      UniProtKB/TrEMBL
      A0A8M3B0G6

    11. XM_068213374.1 → XP_068069475.1  disks large homolog 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QL07

    12. XM_068213377.1 → XP_068069478.1  disks large homolog 3 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AGS5

    13. XM_068213372.1 → XP_068069473.1  disks large homolog 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QGS1

    14. XM_068213378.1 → XP_068069479.1  disks large homolog 3 isoform X10

      UniProtKB/TrEMBL
      A0A8M9QPI0

    15. XM_068213373.1 → XP_068069474.1  disks large homolog 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QPH5

    16. XM_068213375.1 → XP_068069476.1  disks large homolog 3 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PZS5

    17. XM_068213370.1 → XP_068069471.1  disks large homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QL03

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394917.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      41667..190271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218764.1 → XP_068074865.1  disks large homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1J7

    2. XM_009291193.4 → XP_009289468.1  disks large homolog 3 isoform X16

      UniProtKB/TrEMBL
      A0A8M3AS60
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00228
      Location:383 → 467
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:132 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:640 → 818
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:312 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    3. XM_068218769.1 → XP_068074870.1  disks large homolog 3 isoform X8

      UniProtKB/TrEMBL
      A0A8M9QBK2

    4. XM_009291192.4 → XP_009289467.1  disks large homolog 3 isoform X15

      UniProtKB/TrEMBL
      A0A8M9QPI1
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:658 → 836
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    5. XM_021472851.2 → XP_021328526.1  disks large homolog 3 isoform X14

      UniProtKB/TrEMBL
      A0A8M9QGS9
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:686 → 864
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    6. XM_021472850.2 → XP_021328525.1  disks large homolog 3 isoform X13

      UniProtKB/TrEMBL
      A0A8M9Q5B2
      Conserved Domains (5) summary
      cd12029
      Location:520 → 584
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:694 → 872
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    7. XM_021472842.2 → XP_021328517.1  disks large homolog 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QBJ7
      Conserved Domains (6) summary
      cd12029
      Location:569 → 633
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00228
      Location:450 → 534
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:150 → 234
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:743 → 921
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:330 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:109 → 149
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    8. XM_068218773.1 → XP_068074874.1  disks large homolog 3 isoform X12

      UniProtKB/TrEMBL
      A0A8M9PZT0

    9. XM_068218772.1 → XP_068074873.1  disks large homolog 3 isoform X11

      UniProtKB/TrEMBL
      A0A8M3B0G6

    10. XM_068218767.1 → XP_068074868.1  disks large homolog 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QL07

    11. XM_068218770.1 → XP_068074871.1  disks large homolog 3 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AGS5

    12. XM_068218765.1 → XP_068074866.1  disks large homolog 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QGS1

    13. XM_068218771.1 → XP_068074872.1  disks large homolog 3 isoform X10

      UniProtKB/TrEMBL
      A0A8M9QPI0

    14. XM_068218766.1 → XP_068074867.1  disks large homolog 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QPH5

    15. XM_068218768.1 → XP_068074869.1  disks large homolog 3 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PZS5

    16. XM_068218763.1 → XP_068074864.1  disks large homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QL03

    17. XM_009291194.4 → XP_009289469.1  disks large homolog 3 isoform X17

      See identical proteins and their annotated locations for XP_009289469.1

      UniProtKB/TrEMBL
      A0A2R8PXW1, A5PKT0, F6NMH9
      Conserved Domains (2) summary
      cd12029
      Location:19 → 85
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001098742.1: Suppressed sequence

      Description
      NM_001098742.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DLG3 (GeneID:1741).
    Nucleotide Protein Strain
    Heading Accession and Version

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