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    sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 402915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sult1st4provided by ZNC
    Official Full Name
    sulfotransferase family 1, cytosolic sulfotransferase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2054
    See related
    Ensembl:ENSDARG00000003181 AllianceGenome:ZFIN:ZDB-GENE-040426-2054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:76922
    Summary
    Predicted to enable aryl sulfotransferase activity. Predicted to be involved in sulfation. Predicted to act upstream of or within catecholamine metabolic process. Predicted to be active in cytoplasm. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sult1st4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53171006..53179639, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53292427..53301104, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene gamma-aminobutyric acid type A receptor subunit delta Neighboring gene cilia and flagella associated protein 74

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel zebrafish SULT1 cytosolic sulfotransferase: cloning, expression, characterization, and developmental expression study. Liu MY, et al. Arch Biochem Biophys, 2005 May 1. PMID 15820212
    2. Identification of a novel thyroid hormone-sulfating cytosolic sulfotransferase, SULT1 ST5, from zebrafish. Yasuda S, et al. FEBS J, 2005 Aug. PMID 16045754
    3. Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs. Xi Y, et al. Aquat Toxicol, 2016 Aug. PMID 27218426
    4. A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Yamauchi K, et al. Genes Genet Syst, 2019 Dec 10. PMID 31748465
    5. Sulfation of drug compounds by the zebrafish cytosolic sulfotransferases (SULTs). Kurogi K, et al. Drug Metab Lett, 2010 Apr. PMID 20446911

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase family 1, cytosolic sulfotransferase 4
    NP_991183.1
    XP_021333897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205620.2 → NP_991183.1  sulfotransferase family 1, cytosolic sulfotransferase 4

      See identical proteins and their annotated locations for NP_991183.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066584
      UniProtKB/TrEMBL
      Q6XZC1
      Related
      ENSDARP00000035957.6, ENSDART00000030557.8
      Conserved Domains (1) summary
      pfam00685
      Location:46 → 297
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      53171006..53179639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478222.2 → XP_021333897.1  sulfotransferase family 1, cytosolic sulfotransferase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQS2
      Conserved Domains (1) summary
      pfam00685
      Location:46 → 305
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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