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Conserved domains on  [gi|45387665|ref|NP_991183|]
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sulfotransferase family 1, cytosolic sulfotransferase 4 [Danio rerio]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 4.57e-91

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 271.14  E-value: 4.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665    46 PDDILIATYPKAGTTWVSYILDLLYFGSDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtSPRLIKTHL 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-SPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   120 PVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPDPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQKKRSyPNM 199
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPP-GNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   200 LYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVGDWKSHFTV 279
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 45387665   280 AQNERFDEVYKQKMKNSG 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 4.57e-91

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 271.14  E-value: 4.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665    46 PDDILIATYPKAGTTWVSYILDLLYFGSDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtSPRLIKTHL 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-SPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   120 PVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPDPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQKKRSyPNM 199
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPP-GNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   200 LYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVGDWKSHFTV 279
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 45387665   280 AQNERFDEVYKQKMKNSG 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 40-298 9.68e-33

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 123.49  E-value: 9.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   40 KNFQARPDDILIATYPKAGTTWVSYILDLLYFGSDENQTSQPIVQR-----VPFLESCFQEFSTISGTEMADNlptspRL 114
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKGN-----TL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665  115 IKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPDP-GDWDSYLDKFMQGQNVFGSWFDHVSGWWQKK 193
Cdd:PLN02164 148 FSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAY 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665  194 RSYPN-MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEK-----EKITKGVQFDAMKqNTLIN-----HVTIPFLDCKiS 262
Cdd:PLN02164 228 QENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEekgvvEKVVKLCSFETLK-NLEANkgekdREDRPAVYAN-S 305

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 45387665  263 PFMRKGKVGDWKSHFTVAQNERFDEVYKQKMKNSGV 298
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
199-250 3.10e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 41.54  E-value: 3.10e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 45387665 199 MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKgvqfdamKQNTLIN 250
Cdd:COG4424 176 PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK-------KQADEPS 220
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 4.57e-91

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 271.14  E-value: 4.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665    46 PDDILIATYPKAGTTWVSYILDLLYFGSDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtSPRLIKTHL 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-SPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   120 PVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPDPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQKKRSyPNM 199
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPP-GNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   200 LYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVGDWKSHFTV 279
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 45387665   280 AQNERFDEVYKQKMKNSG 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 40-298 9.68e-33

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 123.49  E-value: 9.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   40 KNFQARPDDILIATYPKAGTTWVSYILDLLYFGSDENQTSQPIVQR-----VPFLESCFQEFSTISGTEMADNlptspRL 114
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKGN-----TL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665  115 IKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPDP-GDWDSYLDKFMQGQNVFGSWFDHVSGWWQKK 193
Cdd:PLN02164 148 FSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAY 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665  194 RSYPN-MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEK-----EKITKGVQFDAMKqNTLIN-----HVTIPFLDCKiS 262
Cdd:PLN02164 228 QENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEekgvvEKVVKLCSFETLK-NLEANkgekdREDRPAVYAN-S 305

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 45387665  263 PFMRKGKVGDWKSHFTVAQNERFDEVYKQKMKNSGV 298
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
55-227 1.22e-04

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 41.89  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665    55 PKAGTTWVSYILDL--LYFGSDENQTSQPIV-----QRVPFLESCFQ--EFSTISGTEMADNLPtSPRLIKTHLPvqlvp 125
Cdd:pfam13469   7 PRSGTTLLHRLLAAhpDVRPPEETWFVIPRIlallqAWGKSLEALARvpSYARWLCDKSPSHLF-HLDLLLKAFP----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387665   126 ksfweqNSRVVYVARNAKDNAVSyfhfDRMNMVQPDPGDWdSYLDKFMQGQNVfGSWFDHVSGWWQKKRSYP--NMLYMF 203
Cdd:pfam13469  81 ------DAKFIHLHRDPVDTVIS----SYCSLFGFTLSSY-STAFLRDIGLAL-ARWSRAYERLMAARARVPpgRFLDVR 148

                         170       180
                  ....*....|....*....|....
gi 45387665   204 FEDLSEDTGREVNRLCSFLGLSTS 227
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLGLPWD 172
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
199-250 3.10e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 41.54  E-value: 3.10e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 45387665 199 MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKgvqfdamKQNTLIN 250
Cdd:COG4424 176 PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK-------KQADEPS 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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