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    pkc-3 Protein kinase C-like 3 [ Caenorhabditis elegans ]

    Gene ID: 173914, updated on 9-Dec-2024

    Summary

    Official Symbol
    pkc-3
    Official Full Name
    Protein kinase C-like 3
    Primary source
    WormBase:WBGene00004034
    Locus tag
    CELE_F09E5.1
    See related
    AllianceGenome:WB:WBGene00004034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including antifungal innate immune response; gonad development; and response to wounding. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Is expressed in several structures, including D; Psub4; enteric muscle; hypodermis; and pharyngeal-intestinal valve. Orthologous to human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pkc-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (5380027..5384169)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin prdx-2 Neighboring gene ncRNA Neighboring gene Cytosolic carboxypeptidase 6 Neighboring gene putative splicing factor, arginine/serine-rich 4 Neighboring gene Putative nudix hydrolase 6 Neighboring gene BRCA1-associated protein homolog 2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables diacylglycerol-dependent serine/threonine kinase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    Process Evidence Code Pubs
    involved_in antifungal innate immune response PubMed 
    involved_in cell differentiation  
    involved_in defense response to fungus PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in establishment of cell polarity  
    involved_in establishment or maintenance of cell polarity PubMed 
    involved_in gastrulation  
    involved_in gonad development PubMed 
    involved_in gonadal mesoderm development  
    involved_in intracellular signal transduction  
    involved_in protein localization PubMed 
    involved_in protein localization to plasma membrane  
    involved_in protein phosphorylation  
    involved_in response to wounding PubMed 
    involved_in single fertilization  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in cell cortex PubMed 
    located_in cortical actin cytoskeleton PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol PubMed 
    located_in membrane PubMed 
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Protein kinase C-like 3
    NP_495011.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5380027..5384169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062610.9 → NP_495011.1  Protein kinase C-like 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7VJC8, Q19266
      Conserved Domains (4) summary
      cd06404
      Location:13 → 95
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:253 → 522
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:128 → 178
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:257 → 586
      PKc_like; Protein Kinases, catalytic domain
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