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nrx-1 Neurexin-3-beta [ Caenorhabditis elegans ]

Gene ID: 179503, updated on 4-Jan-2025

Summary

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Official Symbol
nrx-1
Official Full Name
Neurexin-3-beta
Primary source
WormBase:WBGene00007799
Locus tag
CELE_C29A12.4
See related
AllianceGenome:WB:WBGene00007799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of receptor clustering. Located in presynaptic active zone. Is expressed in nervous system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2; alcohol dependence; and nicotine dependence. Orthologous to several human genes including NRXN1 (neurexin 1) and NRXN3 (neurexin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nrx-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
30
Sequence:
Chromosome: V; NC_003283.11 (10825011..10846703)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene Suppressor of activated egl-4 protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin. Muirhead CS, et al. G3 (Bethesda), 2024 Aug 7. PMID 38781440, Free PMC Article
  2. Neurexin controls plasticity of a mature, sexually dimorphic neuron. Hart MP, et al. Nature, 2018 Jan 10. PMID 29323291, Free PMC Article
  3. Neurexin directs partner-specific synaptic connectivity in C. elegans. Philbrook A, et al. Elife, 2018 Jul 24. PMID 30039797, Free PMC Article
  4. Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components. Oliver D, et al. PLoS Genet, 2022 Jan. PMID 35089924, Free PMC Article
  5. Directional Trans-Synaptic Labeling of Specific Neuronal Connections in Live Animals. Desbois M, et al. Genetics, 2015 Jul. PMID 25917682, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components.
    Title: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components.
  2. Starvation-induced remodeling is also dependent on neuroligin/nlg-1, the canonical binding partner for neurexin/nrx-1, and the transcription factors FOXO/daf-16 and HSF1/hsf-1 hsf-1 and daf-16.
    Title: Stress-Induced Neuron Remodeling Reveals Differential Interplay Between Neurexin and Environmental Factors in Caenorhabditis elegans.
  3. neurexin controls plasticity of a mature, sexually dimorphic neuron
    Title: Neurexin controls plasticity of a mature, sexually dimorphic neuron.
  4. study found neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions
    Title: Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Neurexin-3-beta
NP_001122868.2
  • Confirmed by transcript evidence
NP_001256262.1
  • Confirmed by transcript evidence
NP_001256263.1
  • Confirmed by transcript evidence
NP_001256264.1
  • Confirmed by transcript evidence
NP_001256265.1
  • Confirmed by transcript evidence
NP_001256266.1
  • Confirmed by transcript evidence
NP_001256267.1
  • Confirmed by transcript evidence
NP_001256268.1
  • Confirmed by transcript evidence
NP_001256270.1
  • Confirmed by transcript evidence
NP_001263859.1
  • Confirmed by transcript evidence
NP_001263860.1
  • Confirmed by transcript evidence
NP_001294674.1
  • Confirmed by transcript evidence
NP_001364673.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10825011..10846703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269333.4 → NP_001256262.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256262.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18291, Q18294
    Conserved Domains (3) summary
    cd00054
    Location:654 → 689
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:468 → 625
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:1129 → 1265
    Laminin_G_2; Laminin G domain

  2. NM_001129396.5 → NP_001122868.2  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122868.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7UQ09
    Conserved Domains (3) summary
    cd00054
    Location:654 → 689
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:468 → 625
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:1129 → 1265
    Laminin_G_2; Laminin G domain

  3. NM_001276930.3 → NP_001263859.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263859.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAJ6
    Conserved Domains (3) summary
    cd00054
    Location:663 → 698
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:477 → 634
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:1138 → 1274
    Laminin_G_2; Laminin G domain

  4. NM_001276931.3 → NP_001263860.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAJ7
    Conserved Domains (3) summary
    cd00054
    Location:663 → 698
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:477 → 634
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:1138 → 1274
    Laminin_G_2; Laminin G domain

  5. NM_001269334.3 → NP_001256263.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256263.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6S5

  6. NM_001269335.3 → NP_001256264.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256264.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6S6

  7. NM_001307745.4 → NP_001294674.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6EZT1

  8. NM_001269336.2 → NP_001256265.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256265.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P874

  9. NM_001269337.3 → NP_001256266.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLH5

  10. NM_001269338.1 → NP_001256267.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P875

  11. NM_001269339.3 → NP_001256268.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256268.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ40

  12. NM_001377602.2 → NP_001364673.1  Neurexin-3-beta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P876

  13. NM_001269341.3 → NP_001256270.1  Neurexin-3-beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6S7
Nucleotide Protein
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