T22F3.2 USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase 36 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T22F3.2
Official Full Name: USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase 36
Primary source: WormBase:WBGene00020695
Locus tag: CELE_T22F3.2
See related: AllianceGenome:WB:WBGene00020695
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T22F3.2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (3586639..3589012)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22F3.2 (e-PCR)
- UniSTS:306623

T22F3.4 (e-PCR)
- UniSTS:317131

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase 36

NP_001309504.1

Confirmed by transcript evidence

NP_741517.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3586639..3589012

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171442.11 → NP_741517.2 Ubiquitin carboxyl-terminal hydrolase 36 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741517.2

Status: REVIEWED

UniProtKB/TrEMBL

H2L010

Conserved Domains (1) summary

cd02257
Location:163 → 378

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001322541.3 → NP_001309504.1 USP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPT0

Conserved Domains (1) summary

cd02257
Location:7 → 67

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...