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    mis-12 uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 171927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mis-12
    Official Full Name
    uncharacterized protein
    Primary source
    WormBase:WBGene00021648
    Locus tag
    CELE_Y47G6A.24
    See related
    AllianceGenome:WB:WBGene00021648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in kinetochore assembly. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mis-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (3604515..3605744, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Innexin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Welburn JP, et al. Mol Cell, 2010 May 14. PMID 20471944, Free PMC Article
    2. MEL-28/ELYS and CENP-C coordinately control outer kinetochore assembly and meiotic chromosome-microtubule interactions. Hattersley N, et al. Curr Biol, 2022 Jun 6. PMID 35609608, Free PMC Article
    3. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Gerson-Gurwitz A, et al. Cell, 2016 Apr 7. PMID 27020753, Free PMC Article
    4. Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A in Caenorhabditis elegans. Lange KI, et al. Genetics, 2019 Jun. PMID 31018924, Free PMC Article
    5. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Monen J, et al. Nat Cell Biol, 2005 Dec. PMID 16273096

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001122540.1
    • Product from WormBase gene class mis;
      Partially confirmed by transcript evidence; human/fission yeast MIS (MInichromosome Stability) homolog
    NP_491184.1
    • Product from WormBase gene class mis;
      Partially confirmed by transcript evidence; human/fission yeast MIS (MInichromosome Stability) homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3604515..3605744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058783.9 → NP_491184.1  uncharacterized protein CELE_Y47G6A.24 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3R7

    2. NM_001129068.4 → NP_001122540.1  uncharacterized protein CELE_Y47G6A.24 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0D9
      Conserved Domains (1) summary
      pfam05859
      Location:16 → 127
      Mis12; Mis12 protein
    Nucleotide Protein
    Heading Accession and Version

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