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Conserved domains on  [gi|193203490|ref|NP_001122540|]
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uncharacterized protein CELE_Y47G6A.24 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mis12 super family cl20314
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 16-127 6.24e-03

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


The actual alignment was detected with superfamily member pfam05859:

Pssm-ID: 461761  Cd Length: 140  Bit Score: 34.50  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203490   16 FFGFSAGSFSDSI---FNIYVDAWEEVCSNEFKNSLKKLTDKDRlcllsfPFSDKTNE-----------------KAFKM 75
Cdd:pfam05859   5 HLGFTPQSLIDDIinaVNDLLYKAVDAVEQVLLKKLEEGEDAAG------ADEESTEEiekgthkletllearvdKNFDK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 193203490   76 MKRFCVTNIFRIPAS----VTLPECKKMLIASAKEhkslkqvEKEFDEKLEKIRQK 127
Cdd:pfam05859  79 FELYLLRNIFSIPPDlvdwVRLPHDEGLDLDEDGE-------DAELDEEIDQLRRK 127
 
Name Accession Description Interval E-value
Mis12 pfam05859
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 16-127 6.24e-03

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


Pssm-ID: 461761  Cd Length: 140  Bit Score: 34.50  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203490   16 FFGFSAGSFSDSI---FNIYVDAWEEVCSNEFKNSLKKLTDKDRlcllsfPFSDKTNE-----------------KAFKM 75
Cdd:pfam05859   5 HLGFTPQSLIDDIinaVNDLLYKAVDAVEQVLLKKLEEGEDAAG------ADEESTEEiekgthkletllearvdKNFDK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 193203490   76 MKRFCVTNIFRIPAS----VTLPECKKMLIASAKEhkslkqvEKEFDEKLEKIRQK 127
Cdd:pfam05859  79 FELYLLRNIFSIPPDlvdwVRLPHDEGLDLDEDGE-------DAELDEEIDQLRRK 127
 
Name Accession Description Interval E-value
Mis12 pfam05859
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 16-127 6.24e-03

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


Pssm-ID: 461761  Cd Length: 140  Bit Score: 34.50  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203490   16 FFGFSAGSFSDSI---FNIYVDAWEEVCSNEFKNSLKKLTDKDRlcllsfPFSDKTNE-----------------KAFKM 75
Cdd:pfam05859   5 HLGFTPQSLIDDIinaVNDLLYKAVDAVEQVLLKKLEEGEDAAG------ADEESTEEiekgthkletllearvdKNFDK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 193203490   76 MKRFCVTNIFRIPAS----VTLPECKKMLIASAKEhkslkqvEKEFDEKLEKIRQK 127
Cdd:pfam05859  79 FELYLLRNIFSIPPDlvdwVRLPHDEGLDLDEDGE-------DAELDEEIDQLRRK 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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