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    ndua-12 putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [ Caenorhabditis elegans ]

    Gene ID: 177056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndua-12
    Official Full Name
    putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
    Primary source
    WormBase:WBGene00022380
    Locus tag
    CELE_Y94H6A.8
    See related
    AllianceGenome:WB:WBGene00022380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in response to oxidative stress. Located in mitochondrion. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ndua-12 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (2716687..2719834, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene peptidyl-tRNA hydrolase Neighboring gene Low molecular weight phosphotyrosine protein phosphatase Neighboring gene ncRNA Neighboring gene SEP domain-containing protein;UBX domain-containing protein;UBX domain-containing protein 2 Neighboring gene DUF4781 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
    NP_500247.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2716687..2719834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067846.7 → NP_500247.2  putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500247.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N2W7
      Conserved Domains (1) summary
      pfam05071
      Location:42 → 137
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N2W7.2

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