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Conserved domains on  [gi|115534330|ref|NP_500247|]
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putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Caenorhabditis elegans]

Protein Classification

complex I NDUFA12 subunit family protein( domain architecture ID 10523838)

complex I NDUFA12 subunit family protein similar to NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12), an accessory subunit that is not involved in catalysis of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 42-137 2.38e-36

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


:

Pssm-ID: 461542  Cd Length: 96  Bit Score: 120.40  E-value: 2.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330   42 TLVGSDNFGNRYYENN-AYFVPRNRWVEFPDKvwlDYDATQVPPEWHSWLHHITDDAPSVKPP-PTQDWVLEHKEN-TSI 118
Cdd:pfam05071   1 TLVGEDEFGNKYYENKdEELPGRRRWVIYNDG---DYDASQVPPEWHGWLHYITDDPPTEDPIlQPRPWEKPHQPNlTGT 77

                          90
                  ....*....|....*....
gi 115534330  119 YADKKYVPYSTTRTKIQGW 137
Cdd:pfam05071  78 PRAYRGKPYSTTKPKYEAW 96
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 42-137 2.38e-36

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 120.40  E-value: 2.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330   42 TLVGSDNFGNRYYENN-AYFVPRNRWVEFPDKvwlDYDATQVPPEWHSWLHHITDDAPSVKPP-PTQDWVLEHKEN-TSI 118
Cdd:pfam05071   1 TLVGEDEFGNKYYENKdEELPGRRRWVIYNDG---DYDASQVPPEWHGWLHYITDDPPTEDPIlQPRPWEKPHQPNlTGT 77

                          90
                  ....*....|....*....
gi 115534330  119 YADKKYVPYSTTRTKIQGW 137
Cdd:pfam05071  78 PRAYRGKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 39-115 3.27e-23

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 87.99  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  39 RVGTLVGSDNFGNRYYEN---NAYFVPRnRWVEFPDKVwldyDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKEN 115
Cdd:COG3761   24 RKGEKVGEDEFGNRYYRTkdgKALGRER-RWVIYNGYA----EASRVPPEWHGWLHHTTDEPPTEEPYPPRPWEKPHQPN 98
PLN03095 PLN03095
NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional
 34-117 3.55e-22

NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional


Pssm-ID: 215571  Cd Length: 115  Bit Score: 84.93  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  34 LMDATRVGTLVGSDNFGNRYYENNAYFVPRNRWVEFPDKvwLDYDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHK 113
Cdd:PLN03095   3 LVLASRAGRLVGEDEFGNKYYENPSYQSGRHRWVEYADK--DDYNASNIPPEWHGWLHYVNDEPGELEDRTAPRYQLEFI 80


                 ....
gi 115534330 114 ENTS 117
Cdd:PLN03095  81 AGGT 84
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 42-137 2.38e-36

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 120.40  E-value: 2.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330   42 TLVGSDNFGNRYYENN-AYFVPRNRWVEFPDKvwlDYDATQVPPEWHSWLHHITDDAPSVKPP-PTQDWVLEHKEN-TSI 118
Cdd:pfam05071   1 TLVGEDEFGNKYYENKdEELPGRRRWVIYNDG---DYDASQVPPEWHGWLHYITDDPPTEDPIlQPRPWEKPHQPNlTGT 77

                          90
                  ....*....|....*....
gi 115534330  119 YADKKYVPYSTTRTKIQGW 137
Cdd:pfam05071  78 PRAYRGKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 39-115 3.27e-23

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 87.99  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  39 RVGTLVGSDNFGNRYYEN---NAYFVPRnRWVEFPDKVwldyDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKEN 115
Cdd:COG3761   24 RKGEKVGEDEFGNRYYRTkdgKALGRER-RWVIYNGYA----EASRVPPEWHGWLHHTTDEPPTEEPYPPRPWEKPHQPN 98
PLN03095 PLN03095
NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional
 34-117 3.55e-22

NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional


Pssm-ID: 215571  Cd Length: 115  Bit Score: 84.93  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  34 LMDATRVGTLVGSDNFGNRYYENNAYFVPRNRWVEFPDKvwLDYDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHK 113
Cdd:PLN03095   3 LVLASRAGRLVGEDEFGNKYYENPSYQSGRHRWVEYADK--DDYNASNIPPEWHGWLHYVNDEPGELEDRTAPRYQLEFI 80


                 ....
gi 115534330 114 ENTS 117
Cdd:PLN03095  81 AGGT 84
PLN02732 PLN02732
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit
 15-142 9.44e-22

Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit


Pssm-ID: 215389  Cd Length: 159  Bit Score: 84.98  E-value: 9.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  15 FGQMVKEIGGVKAVLKKRYLMdaTRV----GTLVGSDNFGNRYYEN-NAYFVPRNRWVEFPDKVwlDYDATQVPPEWHSW 89
Cdd:PLN02732  21 FLRMLREEGYLRCLADGNLLQ--TKIhnigATLVGVDKFGNKYYQKlGDTQYGRHRWVEYAEKS--RYNASQVPAEWHGW 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115534330  90 LHHIT----DDAPSVKPpptQDWVLEHKENTS------IYADKKYV--PYSTTRTKIQGWQPGEK 142
Cdd:PLN02732  97 LHFITdhtgDELLMLKP---KRYGLEHKENFSgegeeyIYHSKGHTlnPGQKDWTRYQSWQPTKT 158
PRK08183 PRK08183
NADH:ubiquinone oxidoreductase subunit NDUFA12;
39-115 1.15e-20

NADH:ubiquinone oxidoreductase subunit NDUFA12;


Pssm-ID: 236176 [Multi-domain]  Cd Length: 133  Bit Score: 81.57  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  39 RVGTLVGSDNFGNRYYEN---NAYFVPRNRWVEFPDKVwldyDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKEN 115
Cdd:PRK08183  24 RKGERVGEDEFGNVYYRTkggKPSDGRERRWVIYNGYA----EASRIPPEWHGWLHHTVDVPPTKEPYPPREWEKPHQPN 99
PRK06630 PRK06630
hypothetical protein; Provisional
 44-139 1.11e-06

hypothetical protein; Provisional


Pssm-ID: 168631  Cd Length: 99  Bit Score: 44.19  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534330  44 VGSDNFGNRYYE--NNAYFVPRNRWVEFPDKvwldYDATQVPPEWHSWLHHITDDAP-SVKPPPTQdwvlehkENTSIYa 120
Cdd:PRK06630  16 VGEDEFLNQYYEsrNIDYLGRPRRFVIYKNV----NEPTKIPPSWHAWLHHLVNEIPkNIQLFPWQ-------KNNKIV- 83

                         90
                 ....*....|....*....
gi 115534330 121 dKKyvPYSTTRTKIQGWQP 139
Cdd:PRK06630  84 -KK--LPKTSNLKYNRWQP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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