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    DKK3 dickkopf WNT signaling pathway inhibitor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701549, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DKK3provided by VGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by VGNC
    Primary source
    VGNC:VGNC:71804
    See related
    Ensembl:ENSMMUG00000022862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DKK3 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (53614484..53661461)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (54413130..54459507)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene parvin alpha Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2 Neighboring gene uncharacterized LOC114672320 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene uncharacterized LOC114672335 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis. Das DS, et al. PLoS One, 2013. PMID 23667645, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first report of role of DKK3 in the testis and DKK3 mediated regulation of spermatogenesis via WNT-4/beta-CATENIN modulation.
      Title: Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dickkopf-related protein 3
    Names
    dickkopf 3 homolog
    dickkopf homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265749.1 → NP_001252678.1  dickkopf-related protein 3 precursor

      See identical proteins and their annotated locations for NP_001252678.1

      Status: PROVISIONAL

      Source sequence(s)
      JV667376
      UniProtKB/TrEMBL
      F6WN85, F6WNA0, H9EWS7, I0FKV6
      Related
      ENSMMUP00000030109.4, ENSMMUT00000032184.4
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      53614484..53661461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028832590.1 → XP_028688423.1  dickkopf-related protein 3 isoform X2

      UniProtKB/TrEMBL
      F6WN85, F6WNA0, H9EWS7, I0FKV6
      Related
      ENSMMUP00000030106.2, ENSMMUT00000032181.4
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    2. XM_028832592.1 → XP_028688425.1  dickkopf-related protein 3 isoform X2

      UniProtKB/TrEMBL
      F6WN85, F6WNA0, H9EWS7, I0FKV6
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    3. XM_015114739.2 → XP_014970225.2  dickkopf-related protein 3 isoform X1

      Conserved Domains (2) summary
      pfam06607
      Location:304 → 369
      Prokineticin
      pfam04706
      Location:243 → 292
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    4. XM_015114740.2 → XP_014970226.1  dickkopf-related protein 3 isoform X2

      UniProtKB/TrEMBL
      F6WN85, F6WNA0, H9EWS7, I0FKV6
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    5. XM_028832591.1 → XP_028688424.1  dickkopf-related protein 3 isoform X2

      UniProtKB/TrEMBL
      F6WN85, F6WNA0, H9EWS7, I0FKV6
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    Nucleotide Protein
    Heading Accession and Version

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