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Conserved domains on  [gi|966986325|ref|XP_014970226|]
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dickkopf-related protein 3 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dkk3_N_Cys1 cd23014
N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; ...
 41-196 6.72e-93

N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the N-terminal region of Dkk3, including the Cys-1 domain and a region to its N-terminus that shows similarity to Dickkopf-like protein 1 (Dkkl1).


:

Pssm-ID: 438008  Cd Length: 156  Bit Score: 273.98  E-value: 6.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325  41 PQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
Cdd:cd23014    1 PQEEATLNEMFREVEELMEDTQHKLRSAVHEMEAEEAAAKKSSEVNLANLPPNYHNESNTETKVGNNTIHTHQEIDKVTD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966986325 121 NQTGQTVFSETVITSVGDEEGRRSHECIIDEDCGPSKYCQFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:cd23014   81 NKTGSTVFSETVITSVGDEEGKRNHECIIDEDCGPGKYCQFSSFEYKCQPCKTQDMLCTRDSECCGDQLCVWGHCT 156
Dkk3_Cys2 cd23274
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a ...
 199-285 7.52e-45

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk3.


:

Pssm-ID: 438000  Cd Length: 86  Bit Score: 148.53  E-value: 7.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 199 ATRGSNGTICDNQRDCRPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPhsH 278
Cdd:cd23274    2 ATKGEAGTICQYQSDCSPGLCCAFHKALLFPVCTPLPTEGEPCHDPSNHLLDLLSWDLEPEGPLEHCPCAGGLQCQP--H 79


                 ....*..
gi 966986325 279 SLVYVCK 285
Cdd:cd23274   80 GRGSLCE 86
 
Name Accession Description Interval E-value
Dkk3_N_Cys1 cd23014
N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; ...
 41-196 6.72e-93

N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the N-terminal region of Dkk3, including the Cys-1 domain and a region to its N-terminus that shows similarity to Dickkopf-like protein 1 (Dkkl1).


Pssm-ID: 438008  Cd Length: 156  Bit Score: 273.98  E-value: 6.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325  41 PQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
Cdd:cd23014    1 PQEEATLNEMFREVEELMEDTQHKLRSAVHEMEAEEAAAKKSSEVNLANLPPNYHNESNTETKVGNNTIHTHQEIDKVTD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966986325 121 NQTGQTVFSETVITSVGDEEGRRSHECIIDEDCGPSKYCQFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:cd23014   81 NKTGSTVFSETVITSVGDEEGKRNHECIIDEDCGPGKYCQFSSFEYKCQPCKTQDMLCTRDSECCGDQLCVWGHCT 156
Dkk3_Cys2 cd23274
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a ...
 199-285 7.52e-45

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk3.


Pssm-ID: 438000  Cd Length: 86  Bit Score: 148.53  E-value: 7.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 199 ATRGSNGTICDNQRDCRPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPhsH 278
Cdd:cd23274    2 ATKGEAGTICQYQSDCSPGLCCAFHKALLFPVCTPLPTEGEPCHDPSNHLLDLLSWDLEPEGPLEHCPCAGGLQCQP--H 79


                 ....*..
gi 966986325 279 SLVYVCK 285
Cdd:cd23274   80 GRGSLCE 86
Dickkopf_N pfam04706
Dickkopf N-terminal cysteine-rich region; Dickkopf proteins are a class of Wnt antagonists. ...
 146-196 9.87e-20

Dickkopf N-terminal cysteine-rich region; Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.


Pssm-ID: 461401  Cd Length: 51  Bit Score: 81.27  E-value: 9.87e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 966986325  146 ECIIDEDCGPSKYCQFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:pfam04706   1 ECLSDEDCGKGKYCLSSSGESVCLPCRKRRKRCTRDAMCCPGNLCVNGVCV 51
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 208-273 5.01e-03

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 35.90  E-value: 5.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966986325  208 CDNQRDCRPGLCCA---FQRGLLFpvCTPLPVEGELCHdPASRLLDLITWELEpdgalDRCPCASGLLC 273
Cdd:pfam06607  26 CDKDVQCGGGMCCAvslWLRGLRM--CTPLGNEGDECH-PLSHKVPFFGKRQH-----HTCPCLPNLTC 86
 
Name Accession Description Interval E-value
Dkk3_N_Cys1 cd23014
N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; ...
 41-196 6.72e-93

N-terminus of Dickkopf-related protein 3; includes the first cysteine-rich (Cys-1) domain; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the N-terminal region of Dkk3, including the Cys-1 domain and a region to its N-terminus that shows similarity to Dickkopf-like protein 1 (Dkkl1).


Pssm-ID: 438008  Cd Length: 156  Bit Score: 273.98  E-value: 6.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325  41 PQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
Cdd:cd23014    1 PQEEATLNEMFREVEELMEDTQHKLRSAVHEMEAEEAAAKKSSEVNLANLPPNYHNESNTETKVGNNTIHTHQEIDKVTD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966986325 121 NQTGQTVFSETVITSVGDEEGRRSHECIIDEDCGPSKYCQFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:cd23014   81 NKTGSTVFSETVITSVGDEEGKRNHECIIDEDCGPGKYCQFSSFEYKCQPCKTQDMLCTRDSECCGDQLCVWGHCT 156
Dkk3_Cys2 cd23274
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a ...
 199-285 7.52e-45

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 3; Dickkopf 3 (Dkk3) is a secreted protein which, in contrast to Dkk1, Dkk2, and Dkk4, does not interact with LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and thus is a divergent family member that is not considered a true Wnt signaling antagonist. The role of Dkk proteins in cancer is considered mainly tumor suppressive since they are usually down-regulated in cancer cells. Dkk3 links heat shock factor 1 (HSF1) and YAP/TAZ signaling to control aggressive behaviors in cancer-associated fibroblasts; it does so via canonical Wnt signaling. It belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk3.


Pssm-ID: 438000  Cd Length: 86  Bit Score: 148.53  E-value: 7.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 199 ATRGSNGTICDNQRDCRPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPhsH 278
Cdd:cd23274    2 ATKGEAGTICQYQSDCSPGLCCAFHKALLFPVCTPLPTEGEPCHDPSNHLLDLLSWDLEPEGPLEHCPCAGGLQCQP--H 79


                 ....*..
gi 966986325 279 SLVYVCK 285
Cdd:cd23274   80 GRGSLCE 86
Dkk_Cys2 cd23012
second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises ...
 201-285 2.86e-20

second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.


Pssm-ID: 437997  Cd Length: 77  Bit Score: 83.56  E-value: 2.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 201 RGSNGTICDNQRDCRPGLCCAFQrgLLFPVCTPLPVEGELCHDPASRLLDLItwelepdgALDRCPCASGLLCQPH--SH 278
Cdd:cd23012    1 KGREGESCLRSRDCAEGLCCARH--LWSKRCKPILLEGDVCTKPRRKKSRGL--------IFQRCDCGSGLSCRPQpdSH 70


                 ....*..
gi 966986325 279 SLVYVCK 285
Cdd:cd23012   71 KRLHVCQ 77
Dickkopf_N pfam04706
Dickkopf N-terminal cysteine-rich region; Dickkopf proteins are a class of Wnt antagonists. ...
 146-196 9.87e-20

Dickkopf N-terminal cysteine-rich region; Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.


Pssm-ID: 461401  Cd Length: 51  Bit Score: 81.27  E-value: 9.87e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 966986325  146 ECIIDEDCGPSKYCQFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:pfam04706   1 ECLSDEDCGKGKYCLSSSGESVCLPCRKRRKRCTRDAMCCPGNLCVNGVCV 51
Dkk_Cys1 cd23009
first cysteine-rich (Cys-1) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a ...
 146-196 7.11e-18

first cysteine-rich (Cys-1) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-1 domain of Dickkopf proteins 1- 4.


Pssm-ID: 438006  Cd Length: 52  Bit Score: 76.38  E-value: 7.11e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966986325 146 ECIIDEDCGPSKYCQFAS-FQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:cd23009    1 PCISDEDCGTSMYCQSPSdGQYTCQPCRGQRKRCTRDAMCCPGTLCVNGICT 52
Dkkl1 cd23006
Dickkopf-like protein 1; Dickkopf (Dkk) genes comprise an evolutionarily conserved small gene ...
 86-141 2.60e-10

Dickkopf-like protein 1; Dickkopf (Dkk) genes comprise an evolutionarily conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1, also called Dickkopf-like protein 1, cancer/testis antigen 34 (CT34), or sgy/soggy. Soggy is thought to play an important role in testicular development and spermatogenesis, and its abnormal expression may be an important factor in male infertility. It may promote spermatocyte apoptosis, thereby limiting sperm production. In adults, Dkkl1 may reduce testosterone synthesis in Leydig cells. Unlike the other members of the Dickkopf family, Soggy does not contain two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. It contains an N-terminal domain similar to that of the N-terminal region of Dkk3.


Pssm-ID: 438556  Cd Length: 166  Bit Score: 58.46  E-value: 2.60e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966986325  86 NLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQTVFSETVITSVGDEEG 141
Cdd:cd23006    1 DFRGLPRNYHKEENQEHRLGNSTLSSHLQIDKVTDNQTGEVLISEKVVAAIQPAEG 56
Dkk1_Cys2 cd23272
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 1; Dickkopf-1 (Dkk1) is a ...
 201-275 2.58e-04

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 1; Dickkopf-1 (Dkk1) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Elevated expression of Dkk-1 may serve as a negative regulator for modulating the wnt/#-catenin signal pathway. Dkk1 is expressed in various human cancers. It has been studied extensively in mouse models of multiple myeloma that results in osteolytic bone lesions. Studies show that Dkk1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Dkk1 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk1.


Pssm-ID: 437998  Cd Length: 83  Bit Score: 39.29  E-value: 2.58e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966986325 201 RGSNGTICDNQRDCRPGLCCAfqRGLLFPVCTPLPVEGELC---HDPASRLLDLitwelepdgaLDRCPCASGLLCQP 275
Cdd:cd23272    1 KGQEGDTCLRSSDCSEGLCCA--RHFWSKICKPVLKEGQVCtkhRRKGSHGLEI----------FQRCDCGDGLSCRT 66
Dkk4_Cys2 cd23275
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a ...
 201-284 4.75e-04

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Dkk4, which is upregulated by the activated Wnt pathway, contributes to tumor malignancy in variable tumors, promoting tumor cell invasion and progression. Aberrant accumulation of Dkk4 has been shown to promote tumor progression by forming the immune suppressive microenvironment in gastrointestinal stromal tumor, and thus Dkk4 may be used as a tumor biomarker for prognosis prediction and recurrence monitoring. Dkk4 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk4.


Pssm-ID: 438001  Cd Length: 94  Bit Score: 38.81  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 201 RGSNGTICDNQRDCRPGLCCAfqRGLLFPVCTPLPVEGELChdpaSRlldlitwELEPDGA-----LDRCPCASGLLCQP 275
Cdd:cd23275   11 KGQEGESCLRTSDCGPGLCCA--RHFWTKICKPVLLEGQVC----SR-------RGHKDTAqgpeiFQRCDCGPGLSCRS 77

                         90
                 ....*....|....
gi 966986325 276 H-----SHSLVYVC 284
Cdd:cd23275   78 QltgnrQHSRLRVC 91
Dkk2_Cys2 cd23273
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 2; Dickkopf 2 (Dkk2) is a ...
 200-285 5.08e-04

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 2; Dickkopf 2 (Dkk2) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Dkk2 expression is modulated by expression of micro RNA-221 (miRNA-221) in esophageal cancer, and inactivation of Dkk2 may increase Wnt activity with accelerating tumor progression. Dkk2 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk2.


Pssm-ID: 437999  Cd Length: 84  Bit Score: 38.68  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986325 200 TRGSNGTICDNQRDCRPGLCCAfqRGLLFPVCTPLPVEGELC---HDPASRLLDLitwelepdgaLDRCPCASGLLCQP- 275
Cdd:cd23273    1 IKGHEGDPCLRSSDCAEGFCCA--RHFWTKICKPVLRQGEVCtkqRRKGSHGLEI----------FQRCDCAKGLSCKVw 68

                         90
                 ....*....|....*
gi 966986325 276 -----HSHSLVYVCK 285
Cdd:cd23273   69 kdataSSKSRLHVCQ 83
Dkk1_N_Cys1 cd23026
N-terminus of Dickkopf-related protein 1; includes the first cysteine-rich (Cys-1) domain; ...
 147-195 6.62e-04

N-terminus of Dickkopf-related protein 1; includes the first cysteine-rich (Cys-1) domain; Dickkopf-1 (Dkk1) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Elevated expression of Dkk-1 may serve as a negative regulator for modulating the wnt/#-catenin signal pathway. Dkk1 is expressed in various human cancers. It has been studied extensively in mouse models of multiple myeloma that results in osteolytic bone lesions. Studies show that Dkk1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Dkk1 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the N-terminal region of Dkk1, including the Cys-1 domain.


Pssm-ID: 438010 [Multi-domain]  Cd Length: 122  Bit Score: 39.10  E-value: 6.62e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966986325 147 CIIDEDCGPSKYCQFASFQY---TCQPCRDQRTLCTRDSECCGDQLCVWGHC 195
Cdd:cd23026   70 CAEDEECGTDEYCASPTGVGgvqICLACRKRRKRCMRHAMCCPGNYCKNGIC 121
CLPS_Dkk_Cys2 cd23008
Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins; Colipase (also ...
 201-274 2.02e-03

Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins; Colipase (also called CLPS) is a cysteine-rich protein that adopts a similar fold to a cysteine-rich domain (Cys-2) of the Dickkopf (Dkk) family proteins. Colipase functions to prevent the inhibitory effect of bile salts on lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides. Dickkopf proteins are a discrete class of secreted Wnt inhibitors that are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. They possess an N-terminal signal peptide and contain two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. The Dickkopf Cys-2 domain is similar to proteins in the colipase family and it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function.


Pssm-ID: 437995  Cd Length: 82  Bit Score: 36.90  E-value: 2.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966986325 201 RGSNGTICDNQRDCRPGLCCafQRGLLFPVCTPLPVEGELChdPASRLLDLITWELepdgaLDRCPCASGLLCQ 274
Cdd:cd23008    1 KGDEGELCLRSSDCKSGNCC--ARHFWLKICKPVLREGSVC--TKFRLKGSHGLEI-----FQRCPCERGLSCE 65
Dkk4_Cys1 cd23013
first cysteine-rich (Cys-1) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a ...
 147-196 2.24e-03

first cysteine-rich (Cys-1) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Dkk4, which is upregulated by the activated Wnt pathway, contributes to tumor malignancy in variable tumors, promoting tumor cell invasion and progression. Aberrant accumulation of Dkk4 has been shown to promote tumor progression by forming the immune suppressive microenvironment in gastrointestinal stromal tumor, and thus Dkk4 may be used as a tumor biomarker for prognosis prediction and recurrence monitoring. Dkk4 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-1 domain of Dkk4.


Pssm-ID: 438007  Cd Length: 55  Bit Score: 35.90  E-value: 2.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966986325 147 CIIDEDCGPSKYC-QFASFQYTCQPCRDQRTLCTRDSECCGDQLCVWGHCT 196
Cdd:cd23013    5 CLSDKDCSTRKFClAPRDEKPFCATCRGVRRRCQRSAMCCPGTLCVNDVCT 55
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 208-273 5.01e-03

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 35.90  E-value: 5.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966986325  208 CDNQRDCRPGLCCA---FQRGLLFpvCTPLPVEGELCHdPASRLLDLITWELEpdgalDRCPCASGLLC 273
Cdd:pfam06607  26 CDKDVQCGGGMCCAvslWLRGLRM--CTPLGNEGDECH-PLSHKVPFFGKRQH-----HTCPCLPNLTC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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