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    CIITA class II major histocompatibility complex transactivator [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710761, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CIITAprovided by VGNC
    Official Full Name
    class II major histocompatibility complex transactivatorprovided by VGNC
    Primary source
    VGNC:VGNC:71385
    See related
    Ensembl:ENSMMUG00000007777
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CIITA in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (10827489..10889183)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (10920213..10972399)

    Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor 1, cytosolic Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene rho GTPase-activating protein 21-like Neighboring gene C-type lectin domain containing 16A Neighboring gene Dexi homolog Neighboring gene uncharacterized LOC114674400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MHC class I biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MHC class II transactivator
    XP_014981098.2
    XP_014981099.2
    XP_014981100.2
    XP_014981101.2
    XP_014981102.2
    XP_028697126.1
    XP_028697127.1
    XP_028697128.1
    XP_028697129.1
    XP_028697130.1
    XP_028697131.1
    XP_028697132.1
    XP_028697134.1
    XP_028697135.1
    XP_028697136.1
    XP_028697137.1
    XP_028697138.1
    XP_028697139.1
    XP_028697140.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041773.1 Reference Mmul_10 Primary Assembly

      Range
      10827489..10889183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028841293.1 → XP_028697126.1  MHC class II transactivator isoform X1

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (3) summary
      cd00116
      Location:867 → 1192
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1064 → 1091
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:493 → 661
      NACHT; NACHT domain

    2. XM_028841295.1 → XP_028697128.1  MHC class II transactivator isoform X3

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (2) summary
      cd00116
      Location:867 → 1161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:493 → 661
      NACHT; NACHT domain

    3. XM_028841297.1 → XP_028697130.1  MHC class II transactivator isoform X5

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (3) summary
      cd00116
      Location:818 → 1143
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1015 → 1042
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:444 → 612
      NACHT; NACHT domain

    4. XM_028841294.1 → XP_028697127.1  MHC class II transactivator isoform X2

      UniProtKB/TrEMBL
      A0A5F8A5T1, F6S719
      Related
      ENSMMUP00000073242.1, ENSMMUT00000084454.1
      Conserved Domains (3) summary
      cd00116
      Location:866 → 1191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1063 → 1090
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:492 → 660
      NACHT; NACHT domain

    5. XM_028841298.1 → XP_028697131.1  MHC class II transactivator isoform X6

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (3) summary
      cd00116
      Location:817 → 1142
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1014 → 1041
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:443 → 611
      NACHT; NACHT domain

    6. XM_028841296.1 → XP_028697129.1  MHC class II transactivator isoform X4

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (3) summary
      cd00116
      Location:819 → 1144
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1016 → 1043
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:445 → 613
      NACHT; NACHT domain

    7. XM_028841302.1 → XP_028697135.1  MHC class II transactivator isoform X13

      UniProtKB/TrEMBL
      F6S719
      Conserved Domains (3) summary
      cd00116
      Location:770 → 1095
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:967 → 994
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:396 → 564
      NACHT; NACHT domain

    8. XM_028841306.1 → XP_028697139.1  MHC class II transactivator isoform X18

      UniProtKB/TrEMBL
      A0A5F7ZXQ8
      Related
      ENSMMUP00000069427.1, ENSMMUT00000088761.1
      Conserved Domains (3) summary
      cd00116
      Location:741 → 1066
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:938 → 965
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:367 → 535
      NACHT; NACHT domain

    9. XM_028841305.1 → XP_028697138.1  MHC class II transactivator isoform X17

      UniProtKB/TrEMBL
      A0A1D5RDM2, A0A1D5RFJ5
      Related
      ENSMMUP00000058415.2, ENSMMUT00000067056.2
      Conserved Domains (3) summary
      cd00116
      Location:742 → 1067
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:939 → 966
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:368 → 536
      NACHT; NACHT domain

    10. XM_028841301.1 → XP_028697134.1  MHC class II transactivator isoform X12

      UniProtKB/TrEMBL
      A0A5F7ZNK3, H9Z940
      Related
      ENSMMUP00000059089.2, ENSMMUT00000058326.2
      Conserved Domains (3) summary
      cd00116
      Location:789 → 1114
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:986 → 1013
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:415 → 583
      NACHT; NACHT domain

    11. XM_028841299.1 → XP_028697132.1  MHC class II transactivator isoform X10

      UniProtKB/TrEMBL
      H9Z940
      Related
      ENSMMUP00000032638.2, ENSMMUT00000039568.3
      Conserved Domains (3) summary
      cd00116
      Location:790 → 1115
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:987 → 1014
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:416 → 584
      NACHT; NACHT domain

    12. XM_028841304.1 → XP_028697137.1  MHC class II transactivator isoform X16

      UniProtKB/TrEMBL
      A0A1D5RDM2, A0A1D5RFJ5
      Conserved Domains (3) summary
      cd00116
      Location:742 → 1067
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:939 → 966
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:368 → 536
      NACHT; NACHT domain

    13. XM_015125614.2 → XP_014981100.2  MHC class II transactivator isoform X9

      UniProtKB/TrEMBL
      H9Z940
      Conserved Domains (3) summary
      cd00116
      Location:790 → 1115
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:987 → 1014
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:416 → 584
      NACHT; NACHT domain

    14. XM_015125615.2 → XP_014981101.2  MHC class II transactivator isoform X11

      UniProtKB/TrEMBL
      A0A5F7ZNK3, H9Z940
      Related
      ENSMMUP00000067219.1, ENSMMUT00000091622.1
      Conserved Domains (3) summary
      cd00116
      Location:789 → 1114
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:986 → 1013
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:415 → 583
      NACHT; NACHT domain

    15. XM_015125612.2 → XP_014981098.2  MHC class II transactivator isoform X7

      UniProtKB/TrEMBL
      H9Z940
      Conserved Domains (3) summary
      cd00116
      Location:805 → 1130
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1002 → 1029
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:431 → 599
      NACHT; NACHT domain

    16. XM_015125613.2 → XP_014981099.2  MHC class II transactivator isoform X8

      UniProtKB/TrEMBL
      H9Z940
      Conserved Domains (3) summary
      cd00116
      Location:804 → 1129
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1001 → 1028
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:430 → 598
      NACHT; NACHT domain

    17. XM_028841307.1 → XP_028697140.1  MHC class II transactivator isoform X19

      UniProtKB/TrEMBL
      A0A5F7ZXQ8
      Conserved Domains (3) summary
      cd00116
      Location:718 → 1043
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:915 → 942
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:344 → 512
      NACHT; NACHT domain

    18. XM_015125616.2 → XP_014981102.2  MHC class II transactivator isoform X14

      UniProtKB/TrEMBL
      H9Z940
      Conserved Domains (3) summary
      cd00116
      Location:766 → 1091
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:963 → 990
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:392 → 560
      NACHT; NACHT domain

    19. XM_028841303.1 → XP_028697136.1  MHC class II transactivator isoform X15

      UniProtKB/TrEMBL
      H9Z940
      Conserved Domains (3) summary
      cd00116
      Location:765 → 1090
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:962 → 989
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:391 → 559
      NACHT; NACHT domain
    Nucleotide Protein
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