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    Arxes1 adipocyte-related X-chromosome expressed sequence 1 [ Mus musculus (house mouse) ]

    Gene ID: 76219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arxes1provided by MGI
    Official Full Name
    adipocyte-related X-chromosome expressed sequence 1provided by MGI
    Primary source
    MGI:MGI:1923469
    See related
    Ensembl:ENSMUSG00000048355 AllianceGenome:MGI:1923469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spcs3; Spc22/23; 6530401D17Rik
    Summary
    Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Is expressed in axial musculature; eye; incisor; and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Arxes1 in Genome Data Viewer
    Location:
    X F1; X 57.36 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134934116..134935695)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136033367..136034946)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31214 Neighboring gene adipocyte-related X-chromosome expressed sequence 2 Neighboring gene predicted gene, 54084 Neighboring gene brain expressed X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arxes: retrotransposed genes required for adipogenesis. Prokesch A, et al. Nucleic Acids Res, 2011 Apr. PMID 21177646, Free PMC Article
    2. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adipocyte-related X-chromosome expressed sequence 1
    Names
    SPase 22 kDa subunit
    SPase 22/23 kDa subunit
    microsomal signal peptidase 22/23 kDa subunit
    microsomal signal peptidase 23 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029541.3 → NP_083817.1  adipocyte-related X-chromosome expressed sequence 1

      See identical proteins and their annotated locations for NP_083817.1

      Status: VALIDATED

      Source sequence(s)
      AK018307, AL671914, BY287880, CF751524
      Consensus CDS
      CCDS53192.1
      UniProtKB/Swiss-Prot
      B1AUR7, C0HK79, C0HK80, Q8BK31, Q9D365, Q9D6F2
      Related
      ENSMUSP00000062660.3, ENSMUST00000057625.3
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134934116..134935695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003641.1: Suppressed sequence

      Description
      NR_003641.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HK79.1 GenPept UniProtKB/Swiss-Prot:C0HK79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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