NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21617845|ref|NP_083817|]
View 

adipocyte-related X-chromosome expressed sequence 1 [Mus musculus]

Protein Classification

signal peptidase complex subunit 3 family protein( domain architecture ID 10518971)

signal peptidase complex subunit 3 (SPCS3) family protein similar to SPCS3, a component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-173 2.00e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


:

Pssm-ID: 461357  Cd Length: 172  Bit Score: 233.61  E-value: 2.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845     1 MNSLLSRANSLFAFTLSVMAALTLGCILTTAFKDrSAPVRLHVSRILLKKVEDFTGPR-KKSDLGFITFHISADLEKTFD 79
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD-TSSISNIVPSVKVKNSRYYGSVRgKPKDNAKITFDLDADLSPLFN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845    80 WNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGnRNVTLTLSWQVIPIAGILPL 159
Cdd:pfam04573  80 WNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNSLRG-RNVTLTLHWNVMPWVGLLPY 158

                         170
                  ....*....|....
gi 21617845   160 VTGSGRVSVPFPDS 173
Cdd:pfam04573 159 GETAGSSSFTFPDE 172
 
Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-173 2.00e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


Pssm-ID: 461357  Cd Length: 172  Bit Score: 233.61  E-value: 2.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845     1 MNSLLSRANSLFAFTLSVMAALTLGCILTTAFKDrSAPVRLHVSRILLKKVEDFTGPR-KKSDLGFITFHISADLEKTFD 79
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD-TSSISNIVPSVKVKNSRYYGSVRgKPKDNAKITFDLDADLSPLFN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845    80 WNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGnRNVTLTLSWQVIPIAGILPL 159
Cdd:pfam04573  80 WNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNSLRG-RNVTLTLHWNVMPWVGLLPY 158

                         170
                  ....*....|....
gi 21617845   160 VTGSGRVSVPFPDS 173
Cdd:pfam04573 159 GETAGSSSFTFPDE 172
PTZ00116 PTZ00116
signal peptidase; Provisional
 1-174 1.81e-15

signal peptidase; Provisional


Pssm-ID: 173408  Cd Length: 185  Bit Score: 70.46  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845    1 MNSLLSRANSLF---AFTLSVMAALTLGCILTTaFKDRSAPVRLHVsrillKKVEDFTGPRK-KSDLGFITFHISADLEK 76
Cdd:PTZ00116   1 MDNVLNRLNVLSysmALCFLILCLFNYGTSFYL-FDEKEMSTNIKV-----KSVKRLVYNRHiKGDEAVLSLDLSYDMSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845   77 TFDWNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGNrNVTLTLSWQVIPIAGI 156
Cdd:PTZ00116  75 AFNWNLKQLFLYVLVTYETPEKVKNEVIIQDYIITNKKQAKKTYKNFITKYSLKDYNNGLRNN-NINLQVCYKYMPIVGL 153

                        170
                 ....*....|....*...
gi 21617845  157 LPLVTGSgRVSVPFPDSY 174
Cdd:PTZ00116 154 SRSYEGA-KISYKLPAEY 170
 
Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-173 2.00e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


Pssm-ID: 461357  Cd Length: 172  Bit Score: 233.61  E-value: 2.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845     1 MNSLLSRANSLFAFTLSVMAALTLGCILTTAFKDrSAPVRLHVSRILLKKVEDFTGPR-KKSDLGFITFHISADLEKTFD 79
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD-TSSISNIVPSVKVKNSRYYGSVRgKPKDNAKITFDLDADLSPLFN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845    80 WNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGnRNVTLTLSWQVIPIAGILPL 159
Cdd:pfam04573  80 WNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNSLRG-RNVTLTLHWNVMPWVGLLPY 158

                         170
                  ....*....|....
gi 21617845   160 VTGSGRVSVPFPDS 173
Cdd:pfam04573 159 GETAGSSSFTFPDE 172
PTZ00116 PTZ00116
signal peptidase; Provisional
 1-174 1.81e-15

signal peptidase; Provisional


Pssm-ID: 173408  Cd Length: 185  Bit Score: 70.46  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845    1 MNSLLSRANSLF---AFTLSVMAALTLGCILTTaFKDRSAPVRLHVsrillKKVEDFTGPRK-KSDLGFITFHISADLEK 76
Cdd:PTZ00116   1 MDNVLNRLNVLSysmALCFLILCLFNYGTSFYL-FDEKEMSTNIKV-----KSVKRLVYNRHiKGDEAVLSLDLSYDMSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21617845   77 TFDWNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGNrNVTLTLSWQVIPIAGI 156
Cdd:PTZ00116  75 AFNWNLKQLFLYVLVTYETPEKVKNEVIIQDYIITNKKQAKKTYKNFITKYSLKDYNNGLRNN-NINLQVCYKYMPIVGL 153

                        170
                 ....*....|....*...
gi 21617845  157 LPLVTGSgRVSVPFPDSY 174
Cdd:PTZ00116 154 SRSYEGA-KISYKLPAEY 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH