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    Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 76376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc24a2provided by MGI
    Official Full Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 2provided by MGI
    Primary source
    MGI:MGI:1923626
    See related
    Ensembl:ENSMUSG00000037996 AllianceGenome:MGI:1923626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nckx2; 2810021B17Rik; 6330417K15Rik
    Summary
    Enables calcium channel activity. Acts upstream of or within several processes, including learning or memory; neuron cellular homeostasis; and regulation of synaptic plasticity. Located in membrane. Is active in postsynapse and presynapse. Is expressed in lens; lens epithelium; and lens fiber. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 27.0), cerebellum adult (RPKM 20.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc24a2 in Genome Data Viewer
    Location:
    4 C4; 4 40.69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86901361..87148780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86983124..87230652, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene ribosomal protein S6 Neighboring gene alkaline ceramidase 2 Neighboring gene STARR-seq mESC enhancer starr_10707 Neighboring gene STARR-seq mESC enhancer starr_10709 Neighboring gene cadherin-2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:87013999-87014300 Neighboring gene STARR-seq mESC enhancer starr_10712 Neighboring gene STARR-positive B cell enhancer mm9_chr4:87133481-87133782 Neighboring gene predicted gene, 53246 Neighboring gene poly(A) binding protein interacting protein 2B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction. Sakurai K, et al. Sci Rep, 2016 Sep 1. PMID 27580676, Free PMC Article
    2. Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity. Zhang Y, et al. Neuroscience, 2015 Dec 3. PMID 26410028
    3. A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage. Cuomo O, et al. J Neurosci, 2008 Feb 27. PMID 18305240, Free PMC Article
    4. Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice. Moriguchi S, et al. Mol Neurobiol, 2018 May. PMID 28547530
    5. KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2. Lee KH, et al. J Neurosci, 2012 Mar 21. PMID 22442075, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both CaMKII autophosphorylation and CaMKIV phosphorylation significantly decreased in hippocampal CA1 regions of NCKX2+/- relative to control mice.
      Title: Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice.
    2. It has been concluded that NCKX2 is required for the maintenance of efficient Ca2+ extrusion from mouse cones.
      Title: The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction.
    3. Studies describe for the first time the exact location of K(+)-dependent Na(+)/Ca(2)-exchanger (solute carrier family 24, member 2) in the hippocampus of adult mice.
      Title: Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity.
    4. non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity
      Title: SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.
    5. NCKX2 is involved in brain ischemia, and it may represent a new potential target to be investigated in the study of the molecular mechanisms involved in cerebral ischemia.
      Title: A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.
    6. Mouse ortholog of rat Slc24a2 solute carrier family 24, encoding a potassium-dependent sodium-calcium exchanger (partial cds)
      Title: Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term synaptic depression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/potassium/calcium exchanger 2
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 2
    retinal cone Na-Ca+K exchanger
    solute carrier family 24 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110240.1 → NP_001103710.1  sodium/potassium/calcium exchanger 2 isoform 2

      See identical proteins and their annotated locations for NP_001103710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and includes an alternate in-frame exon in the 5' coding region, but lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AL807763, AL954377, AW492765, BC115867
      Consensus CDS
      CCDS51220.1
      UniProtKB/TrEMBL
      Q14BI1
      Related
      ENSMUSP00000102776.3, ENSMUST00000107158.9
      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 711
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. NM_172426.2 → NP_766014.1  sodium/potassium/calcium exchanger 2 isoform 1

      See identical proteins and their annotated locations for NP_766014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK083127, AL807763, AL954377, AW492765, CJ121602
      Consensus CDS
      CCDS18312.1
      UniProtKB/Swiss-Prot
      B1AXF2, B1AXF3, Q14AY1, Q14BI1, Q8BUN9
      Related
      ENSMUSP00000102775.3, ENSMUST00000107157.9
      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 666
      2A1904; K+-dependent Na+/Ca+ exchanger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86901361..87148780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538346.5 → XP_006538409.1  sodium/potassium/calcium exchanger 2 isoform X4

      See identical proteins and their annotated locations for XP_006538409.1

      UniProtKB/TrEMBL
      Q14BI1
      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 711
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. XM_006538345.4 → XP_006538408.1  sodium/potassium/calcium exchanger 2 isoform X3

      See identical proteins and their annotated locations for XP_006538408.1

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 728
      2A1904; K+-dependent Na+/Ca+ exchanger

    3. XM_006538344.5 → XP_006538407.1  sodium/potassium/calcium exchanger 2 isoform X2

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 729
      2A1904; K+-dependent Na+/Ca+ exchanger

    4. XM_006538342.5 → XP_006538405.1  sodium/potassium/calcium exchanger 2 isoform X1

      See identical proteins and their annotated locations for XP_006538405.1

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 746
      2A1904; K+-dependent Na+/Ca+ exchanger

    5. XM_006538347.5 → XP_006538410.1  sodium/potassium/calcium exchanger 2 isoform X5

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 684
      2A1904; K+-dependent Na+/Ca+ exchanger

    6. XM_017320436.3 → XP_017175925.1  sodium/potassium/calcium exchanger 2 isoform X6

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 667
      2A1904; K+-dependent Na+/Ca+ exchanger

    7. XM_006538349.4 → XP_006538412.1  sodium/potassium/calcium exchanger 2 isoform X9

      See identical proteins and their annotated locations for XP_006538412.1

      UniProtKB/TrEMBL
      Q14AY1
      Related
      ENSMUSP00000102773.2, ENSMUST00000107155.8
      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 649
      2A1904; K+-dependent Na+/Ca+ exchanger

    8. XM_036164527.1 → XP_036020420.1  sodium/potassium/calcium exchanger 2 isoform X10

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 636
      2A1904; K+-dependent Na+/Ca+ exchanger

    9. XM_006538348.4 → XP_006538411.1  sodium/potassium/calcium exchanger 2 isoform X8

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 653
      2A1904; K+-dependent Na+/Ca+ exchanger

    10. XM_036164526.1 → XP_036020419.1  sodium/potassium/calcium exchanger 2 isoform X9

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 649
      2A1904; K+-dependent Na+/Ca+ exchanger

    11. XM_036164525.1 → XP_036020418.1  sodium/potassium/calcium exchanger 2 isoform X7

      UniProtKB/Swiss-Prot
      B1AXF2, B1AXF3, Q14AY1, Q14BI1, Q8BUN9
      Related
      ENSMUSP00000043937.5, ENSMUST00000044990.11
      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 666
      2A1904; K+-dependent Na+/Ca+ exchanger

    12. XM_017320435.2 → XP_017175924.1  sodium/potassium/calcium exchanger 2 isoform X5

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 684
      2A1904; K+-dependent Na+/Ca+ exchanger

    13. XM_030253877.1 → XP_030109737.1  sodium/potassium/calcium exchanger 2 isoform X4

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 711
      2A1904; K+-dependent Na+/Ca+ exchanger

    14. XM_006538343.4 → XP_006538406.1  sodium/potassium/calcium exchanger 2 isoform X1

      See identical proteins and their annotated locations for XP_006538406.1

      Conserved Domains (1) summary
      TIGR00927
      Location:99 → 746
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUN9.1 GenPept UniProtKB/Swiss-Prot:Q8BUN9

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