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Conserved domains on  [gi|27369563|ref|NP_766014|]
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sodium/potassium/calcium exchanger 2 isoform 1 [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-666 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 726.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563     99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    326 KPRLQRGGSSASL------------------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGS 364
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    365 YGKLKYYDTMTE---------EGRFREKASILHKIAKKKCQVDENERQ----------NGAANHVEKIELPNS------- 418
Cdd:TIGR00927  737 EGEEVEDEGEGEaegkhevetEGDRKETEHEGETEAEGKEDEDEGEIQagedgemkgdEGAEGKVEHEGETEAgekdehe 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    419 -TSTEVEMTPSSEASEPVQNGNLSHNIEAADAPKAT-------------------------------ETAEEEDDQPLSL 466
Cdd:TIGR00927  817 gQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    467 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 546
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    547 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 626
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 27369563    627 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 666
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-666 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 726.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563     99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    326 KPRLQRGGSSASL------------------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGS 364
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    365 YGKLKYYDTMTE---------EGRFREKASILHKIAKKKCQVDENERQ----------NGAANHVEKIELPNS------- 418
Cdd:TIGR00927  737 EGEEVEDEGEGEaegkhevetEGDRKETEHEGETEAEGKEDEDEGEIQagedgemkgdEGAEGKVEHEGETEAgekdehe 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    419 -TSTEVEMTPSSEASEPVQNGNLSHNIEAADAPKAT-------------------------------ETAEEEDDQPLSL 466
Cdd:TIGR00927  817 gQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    467 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 546
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    547 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 626
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 27369563    627 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 666
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-651 3.43e-40

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 149.13  E-value: 3.43e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 316 gdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkYYDTMTEEgrfrekasilhkiakkkc 395
Cdd:COG0530 126 ------------------------------------------------------IRRARKEP------------------ 133

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 396 qvdenerqngaanhvekielpnststevemtpsseasepvqngnlshnieaadapkatetAEEEDDQPLSLSWPTNTRKQ 475
Cdd:COG0530 134 ------------------------------------------------------------AWEEVEEELEEKPKMSLWKA 153

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 476 ATFLIVfpivfplwitlpdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLI 555
Cdd:COG0530 154 LLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELA 204

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 556 TSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMN 634
Cdd:COG0530 205 TSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIG 275

                       490
                ....*....|....*..
gi 27369563 635 KILGFIMFGLYFVFLVV 651
Cdd:COG0530 276 RWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 1.38e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 122.71  E-value: 1.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27369563   219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 534-651 9.81e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.84  E-value: 9.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  534 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 613
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27369563  614 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 651
Cdd:PRK10734 270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-666 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 726.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563     99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    326 KPRLQRGGSSASL------------------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGS 364
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    365 YGKLKYYDTMTE---------EGRFREKASILHKIAKKKCQVDENERQ----------NGAANHVEKIELPNS------- 418
Cdd:TIGR00927  737 EGEEVEDEGEGEaegkhevetEGDRKETEHEGETEAEGKEDEDEGEIQagedgemkgdEGAEGKVEHEGETEAgekdehe 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    419 -TSTEVEMTPSSEASEPVQNGNLSHNIEAADAPKAT-------------------------------ETAEEEDDQPLSL 466
Cdd:TIGR00927  817 gQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    467 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 546
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    547 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 626
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 27369563    627 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 666
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 138-648 2.64e-94

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 293.46  E-value: 2.64e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   138 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 217
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   218 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLLMLITFFLDNVimwWESLLLLTAYFAYVVFMKFNVQVERWVKqmisr 297
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVK----- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   298 nnvikvtvpeaqaksptagdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyYDTMTEE 377
Cdd:TIGR00367 151 -------------------------------------------------------------------------YDTYTEE 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   378 grfrekasilhkiakkkcQVDENERqngaanhvekielpnststevemtpsseasepvqngnlshnieaadapkatetae 457
Cdd:TIGR00367 158 ------------------NLDENNR------------------------------------------------------- 164

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   458 eeddqplslswptntRKQATFLIVFPIVFplwitlpdvrkpasrkffpitffgsITWIAVFSYLMVWWAHQVGETIGISE 537
Cdd:TIGR00367 165 ---------------RPQIFFSLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGISE 204

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   538 EIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIihRFSPVTVSSNGLFCAIVLLFI 617
Cdd:TIGR00367 205 KIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPI--PVEPLAYNLDAPVMVIVTLLL 282

                         490       500       510
                  ....*....|....*....|....*....|.
gi 27369563   618 MLLFVIlSIALCKWrmnkiLGFIMFGLYFVF 648
Cdd:TIGR00367 283 MLFFKT-SMKLGRW-----EGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-651 3.43e-40

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 149.13  E-value: 3.43e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 316 gdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkYYDTMTEEgrfrekasilhkiakkkc 395
Cdd:COG0530 126 ------------------------------------------------------IRRARKEP------------------ 133

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 396 qvdenerqngaanhvekielpnststevemtpsseasepvqngnlshnieaadapkatetAEEEDDQPLSLSWPTNTRKQ 475
Cdd:COG0530 134 ------------------------------------------------------------AWEEVEEELEEKPKMSLWKA 153

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 476 ATFLIVfpivfplwitlpdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLI 555
Cdd:COG0530 154 LLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELA 204

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 556 TSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMN 634
Cdd:COG0530 205 TSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIG 275

                       490
                ....*....|....*..
gi 27369563 635 KILGFIMFGLYFVFLVV 651
Cdd:COG0530 276 RWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 1.38e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 122.71  E-value: 1.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27369563   219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 503-654 2.52e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 119.24  E-value: 2.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   503 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 582
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27369563   583 VGLPLPWLLyTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 654
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
115-281 2.54e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 97.51  E-value: 2.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 115 EHTQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 194
Cdd:COG0530 132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 195 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLLMLITFFL-DNVIMWWESLLLLTA 273
Cdd:COG0530 208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                ....*...
gi 27369563 274 YFAYVVFM 281
Cdd:COG0530 286 YLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
526-653 3.37e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 85.57  E-value: 3.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563 526 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSS 605
Cdd:COG0530   8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAAL-------IRPLAVDR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 27369563 606 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSV 653
Cdd:COG0530  81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLI 126
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 130-277 6.52e-16

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 78.90  E-value: 6.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   130 ERRKG---AIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGI 206
Cdd:TIGR00367 163 NRRPQiffSLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27369563   207 GTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLLMLITFFLDNVIMWWESLLLLTAYFAY 277
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 97-278 3.39e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.45  E-value: 3.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563    97 DYTPQPPASQEdqAENSTEHTQGDY------------PKDIfSLEERRKGAIILHVIgMIYMFIALAIVCDEFfVPSLTV 164
Cdd:TIGR00845  28 DHARALTEASS--SGSNTGECTGSYyckegvilpiwePQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRF-MASIEV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   165 ITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNVGIGTIVGSAVFNILFVIG 222
Cdd:TIGR00845 103 ITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDLGPSTIVGSAAFNMFIIIA 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27369563   223 MCALF-----SREILNL------TWWPLFRDVSFYIVdllmlITFFLDNVIMWWESLLLL-----TAYFAYV 278
Cdd:TIGR00845 182 ICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFfffplCVVFAWV 248
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 529-659 7.77e-15

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 75.82  E-value: 7.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   529 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL 608
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27369563   609 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKV 659
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 534-651 9.81e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.84  E-value: 9.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  534 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 613
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27369563  614 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 651
Cdd:PRK10734 270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 140-228 4.56e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.59  E-value: 4.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  140 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 219
Cdd:PRK10734 180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254


                 ....*....
gi 27369563  220 VIGMCALFS 228
Cdd:PRK10734 255 VLGLPALIS 263
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 141-653 3.25e-09

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 60.16  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  141 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 218
Cdd:PLN03151 145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  219 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMisR 297
Cdd:PLN03151 224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  298 NNVIKVTVPEAQAKSPTAGDKDGPTLPSKPRLQRGGSSASLHNSLMrnsifQLMihtldpLAEELGSYGKlkyydtmtee 377
Cdd:PLN03151 302 LDVVTPLLPVQGSIFSPSVEEDESMYSPLLESDTESDVPRLQTSLP-----QWM------WASNVAIYSN---------- 360

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  378 grfrekasilHKIakkKCQVDENERQNGAANHvEKIELPNSTST--------EVEMTPSSEASEP-VQNGNLSHNIEAAD 448
Cdd:PLN03151 361 ----------HFA---KGSVHDEERPPWGWTD-EGAEVESSLFScsklfsllEMPLTIPRRLTIPiVEEDRWSKTYAVAS 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  449 APKAtetaeeeddqPLSLSWPTNTR-------KQATFLIVFPIVFPLWI-----TLPDvrKPASRKFFPIT---FFGSIT 513
Cdd:PLN03151 427 ASLA----------PVLLAFLWSSQddvslqaRIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMSIV 494

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  514 WIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLPWL 590
Cdd:PLN03151 495 WFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSML 573

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369563  591 LYTIIHRFSPVTV-SSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 653
Cdd:PLN03151 574 LGAWSKSPESYMLpEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 522-636 4.14e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.42  E-value: 4.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563  522 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtiihrfsPV 601
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIR-------PF 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27369563  602 TVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 636
Cdd:PRK10734  95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 507-620 2.80e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 50.56  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369563   507 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 585
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 27369563   586 PLPWLLYTIIH-------RFSPVTVS-SNGLFCAIVLLFIMLL 620
Cdd:TIGR00845 838 GVAWSIAAIYHaangtqfKVSPGTLAfSVTLFTIFAFICIGVL 880
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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