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    ZG16 zymogen granule protein 16 [ Homo sapiens (human) ]

    Gene ID: 653808, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZG16provided by HGNC
    Official Full Name
    zymogen granule protein 16provided by HGNC
    Primary source
    HGNC:HGNC:30961
    See related
    Ensembl:ENSG00000174992 MIM:617311; AllianceGenome:HGNC:30961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JCLN; JCLN1; ZG16A
    Summary
    Predicted to enable carbohydrate binding activity and peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in Golgi lumen and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon (RPKM 333.1), small intestine (RPKM 82.8) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See ZG16 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29778256..29782973)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30060382..30065096)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29789577..29794294)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10669 Neighboring gene uncharacterized LOC124903673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10670 Neighboring gene chromosome 16 open reading frame 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10673 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:29774929-29775066 Neighboring gene Sharpr-MPRA regulatory region 10200 Neighboring gene Sharpr-MPRA regulatory region 1439 Neighboring gene uncharacterized LOC124903675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10674 Neighboring gene uncharacterized LOC105371167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10675 Neighboring gene kinesin family member 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Conformational switches and redox properties of the colon cancer-associated human lectin ZG16. Javitt G, et al. FEBS J, 2021 Nov. PMID 34077620, Free PMC Article
    2. Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer. Meng H, et al. BMC Cancer, 2018 Apr 16. PMID 29661177, Free PMC Article
    3. Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides. Hanashima S, et al. Chembiochem, 2015 Jul 6. PMID 25919894, Free PMC Article
    4. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. Tateno H, et al. Glycobiology, 2012 Feb. PMID 21893569
    5. cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut. Cronshagen U, et al. Eur J Cell Biol, 1994 Dec. PMID 7720729

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer.
      Title: ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer.
    2. Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
      Title: Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
    3. our study demonstrated that ZG16 expression was sequentially reduced from normal, adenoma, to carcinoma. Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer initiation and progression. ZG16 may serve as a potential biomarker for diagnosis and prognosis of colorectal cancer
      Title: Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer.
    4. Data show that an upstream regulator of zymogen granule protein 16 (ZG16), miR-196a, which was significantly overexpressed in colorectal cancer (CRC) and promotes cell growth and stemness.
      Title: Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer.
    5. Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p.
      Title: Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides.
    6. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system.
      Title: Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system.
    7. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site.
      Title: Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold.
    8. hZG16 was markedly down-regulated in hepatocellular carcinoma (HCC) as indicated by RT-PCR.
      Title: hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43571, FLJ92276, MGC34820, MGC183567

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in suppression of symbiont entry into host IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mucus layer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zymogen granule membrane protein 16
    Names
    jacalin-like lectin domain containing
    secretory lectin ZG16
    zymogen granule protein 16 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152338.4 → NP_689551.3  zymogen granule membrane protein 16 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009133, KF456182
      Consensus CDS
      CCDS54000.1
      UniProtKB/Swiss-Prot
      B2R4Z3, B9EK72, O60844
      Related
      ENSP00000383563.4, ENST00000400752.6
      Conserved Domains (1) summary
      cd09611
      Location:36 → 158
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      29778256..29782973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30060382..30065096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60844.3 GenPept UniProtKB/Swiss-Prot:O60844

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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